| Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores X Liu, Z Zhang, J Ruan, Y Pan, VG Magupalli, H Wu, J Lieberman Nature 535 (7610), 153-158, 2016 | 2655 | 2016 |
| Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes A Lu, VG Magupalli, J Ruan, Q Yin, MK Atianand, MR Vos, GF Schröder, ... Cell 156 (6), 1193-1206, 2014 | 1271 | 2014 |
| The pore-forming protein gasdermin D regulates interleukin-1 secretion from living macrophages CL Evavold, J Ruan, Y Tan, S Xia, H Wu, JC Kagan Immunity 48 (1), 35-44. e6, 2018 | 1012 | 2018 |
| FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation JJ Hu, X Liu, S Xia, Z Zhang, Y Zhang, J Zhao, J Ruan, X Luo, X Lou, ... Nature immunology 21 (7), 736-745, 2020 | 691 | 2020 |
| An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells I Zanoni, Y Tan, M Di Gioia, A Broggi, J Ruan, J Shi, CA Donado, F Shao, ... Science 352 (6290), 1232-1236, 2016 | 528 | 2016 |
| Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization L Zhang, S Chen, J Ruan, J Wu, AB Tong, Q Yin, Y Li, L David, A Lu, ... Science 350 (6259), 404-409, 2015 | 417 | 2015 |
| Gasdermin D pore structure reveals preferential release of mature interleukin-1 S Xia, Z Zhang, VG Magupalli, JL Pablo, Y Dong, SM Vora, L Wang, ... Nature 593 (7860), 607-611, 2021 | 392 | 2021 |
| Cryo-EM structure of the gasdermin A3 membrane pore J Ruan, S Xia, X Liu, J Lieberman, H Wu Nature 557 (7703), 62-67, 2018 | 347 | 2018 |
| Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation C Bian, C Xu, J Ruan, KK Lee, TL Burke, W Tempel, D Barsyte, J Li, M Wu, ... The EMBO journal 30 (14), 2829-2842, 2011 | 295 | 2011 |
| Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis Y Yao, T Sun, S Huang, S Dou, L Lin, J Chen, J Ruan, C Mao, F Yu, ... Science translational medicine 4 (130), 130ra48-130ra48, 2012 | 210 | 2012 |
| A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly FI Schmidt, A Lu, JW Chen, J Ruan, C Tang, H Wu, HL Ploegh Journal of Experimental Medicine 213 (5), 771-790, 2016 | 159 | 2016 |
| Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1 Y Li, TM Fu, A Lu, K Witt, J Ruan, C Shen, H Wu Proceedings of the National Academy of Sciences 115 (43), 10845-10852, 2018 | 122 | 2018 |
| Ubiquitin-mediated regulation of RIPK1 kinase activity independent of IKK and MK2 A Annibaldi, SW John, TV Berghe, KN Swatek, J Ruan, G Liccardi, ... Molecular cell 69 (4), 566-580. e5, 2018 | 122 | 2018 |
| SERPINB1-mediated checkpoint of inflammatory caspase activation YJ Choi, S Kim, Y Choi, TB Nielsen, J Yan, A Lu, J Ruan, HR Lee, H Wu, ... Nature immunology 20 (3), 276-287, 2019 | 104 | 2019 |
| Molecular mechanism for NLRP6 inflammasome assembly and activation C Shen, A Lu, WJ Xie, J Ruan, R Negro, EH Egelman, TM Fu, H Wu Proceedings of the National Academy of Sciences 116 (6), 2052-2057, 2019 | 97 | 2019 |
| Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin AJ Russo, SO Vasudevan, SP Méndez-Huergo, P Kumari, A Menoret, ... Nature immunology 22 (2), 154-165, 2021 | 95 | 2021 |
| Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2 A Lu, Y Li, Q Yin, J Ruan, X Yu, E Egelman, H Wu Cell discovery 1 (1), 1-14, 2015 | 95 | 2015 |
| Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes L Robert Hollingsworth, L David, Y Li, AR Griswold, J Ruan, H Sharif, ... Nature communications 12 (1), 189, 2021 | 57 | 2021 |
| Structural insight of gasdermin family driving pyroptotic cell death J Ruan Structural Immunology, 189-205, 2019 | 52 | 2019 |
| Structural basis for specific binding of human MPP8 chromodomain to histone H3 methylated at lysine 9 J Li, Z Li, J Ruan, C Xu, Y Tong, PW Pan, W Tempel, L Crombet, J Min, ... PloS one 6 (10), e25104, 2011 | 50 | 2011 |
Hao WuAsa and Patricia Springer Professor, Boston Children's Hospital and Harvard Medical School在 crystal.harvard.edu 的电子邮件经过验证
