Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family S Anwar, O Peters, S Millership, N Ninkina, N Doig, N Connor-Robson, ... Journal of Neuroscience 31 (20), 7264-7274, 2011 | 238 | 2011 |
Fused in Sarcoma (FUS) Protein Lacking Nuclear Localization Signal (NLS) and Major RNA Binding Motifs Triggers Proteinopathy and Severe Motor Phenotype in Transgenic Mice*♦ TA Shelkovnikova, OM Peters, AV Deykin, N Connor-Robson, ... Journal of biological chemistry 288 (35), 25266-25274, 2013 | 147 | 2013 |
LRRK2 interacts with the vacuolar-type H+-ATPase pump a1 subunit to regulate lysosomal function R Wallings, N Connor-Robson, R Wade-Martins Human molecular genetics 28 (16), 2696-2710, 2019 | 103 | 2019 |
LRRK2: autophagy and lysosomal activity M Madureira, N Connor-Robson, R Wade-Martins Frontiers in neuroscience 14, 498, 2020 | 93 | 2020 |
Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons V Telezhkin, C Schnell, P Yarova, S Yung, E Cope, A Hughes, ... American Journal of Physiology-Cell Physiology 310 (7), C520-C541, 2016 | 91 | 2016 |
LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function M Sloan, J Alegre-Abarrategui, D Potgieter, AK Kaufmann, R Exley, ... Human molecular genetics 25 (5), 951-963, 2016 | 80 | 2016 |
Simultaneous and independent detection of C9ORF72 alleles with low and high number of GGGGCC repeats using an optimised protocol of Southern blot hybridisation VL Buchman, J Cooper-Knock, N Connor-Robson, A Higginbottom, ... Molecular neurodegeneration 8, 1-6, 2013 | 79 | 2013 |
Chronic administration of dimebon ameliorates pathology in Tau P301S transgenic mice OM Peters, N Connor-Robson, VB Sokolov, AY Aksinenko, MS Kukharsky, ... Journal of Alzheimer's disease 33 (4), 1041-1049, 2013 | 78 | 2013 |
Recruitment into stress granules prevents irreversible aggregation of FUS protein mislocalized to the cytoplasm TA Shelkovnikova, HK Robinson, N Connor-Robson, VL Buchman Cell Cycle 12 (19), 3383-3391, 2013 | 75 | 2013 |
An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2 N Connor-Robson, H Booth, JG Martin, B Gao, K Li, N Doig, J Vowles, ... Neurobiology of Disease 127, 512-526, 2019 | 71 | 2019 |
Are rodent models of Parkinson’s disease behaving as they should? S Vingill, N Connor-Robson, R Wade-Martins Behavioural brain research 352, 133-141, 2018 | 69 | 2018 |
RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes HDE Booth, F Wessely, N Connor-Robson, F Rinaldi, J Vowles, C Browne, ... Neurobiology of Disease 129, 56-66, 2019 | 65 | 2019 |
Combinational losses of synucleins reveal their differential requirements for compensating age-dependent alterations in motor behavior and dopamine metabolism N Connor-Robson, OM Peters, S Millership, N Ninkina, VL Buchman Neurobiology of Aging 46, 107-112, 2016 | 60 | 2016 |
CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease N Bengoa-Vergniory, E Faggiani, P Ramos-Gonzalez, E Kirkiz, ... Nature communications 11 (1), 4885, 2020 | 50 | 2020 |
Contrasting effects of α-synuclein and γ-synuclein on the phenotype of cysteine string protein α (CSPα) null mutant mice suggest distinct function of these proteins in neuronal … N Ninkina, OM Peters, N Connor-Robson, O Lytkina, E Sharfeddin, ... Journal of Biological Chemistry 287 (53), 44471-44477, 2012 | 46 | 2012 |
C9ORF72 transcription in a frontotemporal dementia case with two expanded alleles J Cooper-Knock, A Higginbottom, N Connor-Robson, N Bayatti, JJ Bury, ... Neurology 81 (19), 1719-1721, 2013 | 43 | 2013 |
GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model BM Roberts, NM Doig, KR Brimblecombe, EF Lopes, RE Siddorn, ... Nature communications 11 (1), 4958, 2020 | 39 | 2020 |
A novel resource for studying function and dysfunction of α-synuclein: mouse lines for modulation of endogenous Snca gene expression N Ninkina, N Connor-Robson, AA Ustyugov, TV Tarasova, ... Scientific Reports 5 (1), 16615, 2015 | 30 | 2015 |
Striatal dopamine transporter function is facilitated by converging biology of α-Synuclein and cholesterol S Threlfell, AS Mohammadi, BJ Ryan, N Connor-Robson, NJ Platt, ... Frontiers in Cellular Neuroscience 15, 658244, 2021 | 21 | 2021 |
β-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins N Ninkina, SJ Millership, OM Peters, N Connor-Robson, K Chaprov, ... Journal of Biological Chemistry 297 (6), 2021 | 15 | 2021 |