PBPK models for the prediction of in vivo performance of oral dosage forms. D Kostewicz, Aarons, Bolger, Sjögren Eur J Pharm Sci, 2013 | 340* | 2013 |
In vivo methods for drug absorption–Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient … E Sjögren, B Abrahamsson, P Augustijns, D Becker, MB Bolger, ... European Journal of Pharmaceutical Sciences 57, 99-151, 2014 | 308 | 2014 |
In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: application of the mechanistic absorption model GI-Sim E Sjögren, J Westergren, I Grant, G Hanisch, L Lindfors, H Lennernäs, ... European journal of pharmaceutical sciences 49 (4), 679-698, 2013 | 190 | 2013 |
Direct in vivo human intestinal permeability (Peff) determined with different clinical perfusion and intubation methods D Dahlgren, C Roos, E Sjögren, H Lennernäs Journal of pharmaceutical sciences 104 (9), 2702-2726, 2015 | 105 | 2015 |
In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically Based Absorption Models E Sjögren, H Thorn, C Tannergren Molecular pharmaceutics 13 (6), 1763-1778, 2016 | 89 | 2016 |
Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link—a Workshop Summary Report T Heimbach, S Suarez-Sharp, M Kakhi, N Holmstock, A Olivares-Morales, ... The AAPS Journal 21, 1-15, 2019 | 86 | 2019 |
Open systems pharmacology community—an open access, open source, open science approach to modeling and simulation in pharmaceutical sciences J Lippert, R Burghaus, A Edginton, S Frechen, M Karlsson, A Kovar, ... CPT: pharmacometrics & systems pharmacology 8 (12), 878, 2019 | 84 | 2019 |
Applications of clinically relevant dissolution testing: workshop summary report S Suarez-Sharp, M Cohen, F Kesisoglou, A Abend, P Marroum, ... The AAPS Journal 20, 1-14, 2018 | 67 | 2018 |
In Vivo Predictive Dissolution (IPD) and Biopharmaceutical Modeling and Simulation: Future Use of Modern Approaches and Methodologies in a Regulatory Context H Lennernas, A Lindahl, A Van Peer, C Ollier, T Flanagan, R Lionberger, ... Molecular Pharmaceutics 14 (4), 1307-1314, 2017 | 64 | 2017 |
Regional intestinal permeability of three model drugs in human D Dahlgren, C Roos, A Lundqvist, B Abrahamsson, C Tannergren, ... Molecular Pharmaceutics 13 (9), 3013-3021, 2016 | 62 | 2016 |
Human in Vivo Regional Intestinal Permeability: Quantitation Using Site-Specific Drug Absorption Data E Sjogren, D Dahlgren, C Roos, H Lennernas Molecular pharmaceutics 12 (6), 2026-2039, 2015 | 56 | 2015 |
Liver cancer cell lines treated with doxorubicin under normoxia and hypoxia: cell viability and oncologic protein profile IR Dubbelboer, N Pavlovic, F Heindryckx, E Sjögren, H Lennernäs Cancers 11 (7), 1024, 2019 | 52 | 2019 |
In Vivo Mechanisms of Intestinal Drug Absorption from Aprepitant Nanoformulations C Roos, D Dahlgren, S Berg, J Westergren, B Abrahamsson, ... Molecular Pharmaceutics 14 (12), 4233-4242, 2017 | 52 | 2017 |
The multiple depletion curves method provides accurate estimates of intrinsic clearance (CLint), maximum velocity of the metabolic reaction (Vmax), and Michaelis constant (Km … E Sjögren, H Lennernäs, TB Andersson, J Gråsjö, U Bredberg Drug metabolism and disposition 37 (1), 47-58, 2009 | 50 | 2009 |
In vitro release mechanisms of doxorubicin from a clinical bead drug-delivery system E Ahnfelt, E Sjögren, P Hansson, H Lennernäs Journal of Pharmaceutical Sciences 105 (11), 3387-3398, 2016 | 48 | 2016 |
Pulmonary absorption–estimation of effective pulmonary permeability and tissue retention of ten drugs using an ex vivo rat model and computational analysis J Eriksson, E Sjögren, H Thörn, K Rubin, P Bäckman, H Lennernäs European Journal of Pharmaceutics and Biopharmaceutics 124, 1-12, 2018 | 46 | 2018 |
Concomitant intake of alcohol may increase the absorption of poorly soluble drugs JH Fagerberg, E Sjögren, CAS Bergström European Journal of Pharmaceutical Sciences 67, 12-20, 2015 | 46 | 2015 |
Applications of physiologically based biopharmaceutics modeling (PBBM) to support drug product quality: a workshop summary report A Mitra, S Suarez-Sharp, XJH Pepin, T Flanagan, Y Zhao, E Kotzagiorgis, ... Journal of Pharmaceutical Sciences 110 (2), 594-609, 2021 | 43 | 2021 |
The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs D Dahlgren, C Roos, P Johansson, C Tannergren, A Lundqvist, ... International journal of pharmaceutics 547 (1-2), 158-168, 2018 | 43 | 2018 |
Regional intestinal permeability in rats: a comparison of methods C Roos, D Dahlgren, E Sjögren, C Tannergren, B Abrahamsson, ... Molecular pharmaceutics 14 (12), 4252-4261, 2017 | 43 | 2017 |