| BiGGER: a new (soft) docking algorithm for predicting protein interactions PN Palma, L Krippahl, JE Wampler, JJG Moura Proteins: Structure, Function, and Bioinformatics 39 (4), 372-384, 2000 | 393 | 2000 |
| Catechol‐O‐methyltransferase and Its Inhibitors in Parkinson's Disease MJ Bonifácio, PN Palma, L Almeida, P Soares‐da‐Silva CNS drug reviews 13 (3), 352-379, 2007 | 271 | 2007 |
| Discovery of a Long-Acting, Peripherally Selective Inhibitor of Catechol-O-methyltransferase LE Kiss, HS Ferreira, L Torrão, MJ Bonifácio, PN Palma, ... Journal of medicinal chemistry 53 (8), 3396-3411, 2010 | 214 | 2010 |
| Eslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: a comparison with carbamazepine, oxcarbazepine and lacosamide S Hebeisen, N Pires, AI Loureiro, MJ Bonifácio, N Palma, A Whyment, ... Neuropharmacology 89, 122-135, 2015 | 139 | 2015 |
| Pharmacokinetics, Pharmacodynamics and Tolerability of Opicapone, a Novel Catechol-O-Methyltransferase Inhibitor, in Healthy Subjects: Prediction of Slow … L Almeida, JF Rocha, A Falcão, P Nuno Palma, AI Loureiro, R Pinto, ... Clinical pharmacokinetics 52, 139-151, 2013 | 110 | 2013 |
| Opicapone: a short lived and very long acting novel catechol‐O‐methyltransferase inhibitor following multiple dose administration in healthy subjects JF Rocha, L Almeida, A Falcão, PN Palma, AI Loureiro, R Pinto, ... British journal of clinical pharmacology 76 (5), 763-775, 2013 | 94 | 2013 |
| Heteronuclear NMR and Soft Docking: An Experimental Approach for a Structural Model of the Cytochrome c553−Ferredoxin Complex X Morelli, A Dolla, M Czjzek, PN Palma, F Blasco, L Krippahl, JJG Moura, ... Biochemistry 39 (10), 2530-2537, 2000 | 86 | 2000 |
| Eslicarbazepine acetate for the treatment of focal epilepsy: an update on its proposed mechanisms of action P Soares‐da‐Silva, N Pires, MJ Bonifácio, AI Loureiro, N Palma, ... Pharmacology Research & Perspectives 3 (2), e00124, 2015 | 76 | 2015 |
| Structure of the tetraheme cytochrome from Desulfovibrio desulfuricans ATCC 27774: X-ray diffraction and electron paramagnetic resonance studies J Morais, PN Palma, C Frazao, J Caldeira, J LeGall, I Moura, JJG Moura, ... Biochemistry 34 (39), 12830-12841, 1995 | 74 | 1995 |
| A novel approach for assesing macromolecular complexes combining soft‐docking calculations with NMR data XJ Morelli, PN Palma, F Guerlesquin, AC Rigby Protein Science 10 (10), 2131-2137, 2001 | 68 | 2001 |
| Comparative study of ortho-and meta-nitrated inhibitors of catechol-O-methyltransferase: interactions with the active site and regioselectivity of O-methylation PN Palma, ML Rodrigues, M Archer, MJ Bonifacio, AI Loureiro, ... Molecular pharmacology 70 (1), 143-153, 2006 | 65 | 2006 |
| Pharmacological profile of opicapone, a third‐generation nitrocatechol catechol‐O‐methyl transferase inhibitor, in the rat MJ Bonifacio, L Torrao, AI Loureiro, PN Palma, LC Wright, ... British Journal of Pharmacology 172 (7), 1739-1752, 2015 | 64 | 2015 |
| Modeling protein complexes with BiGGER L Krippahl, JJ Moura, PN Palma Proteins: Structure, Function, and Bioinformatics 52 (1), 19-23, 2003 | 63 | 2003 |
| Computation of the binding affinities of catechol‐O‐methyltransferase inhibitors: Multisubstate relative free energy calculations P Nuno Palma, M João Bonifácio, A Isabel Loureiro, P Soares‐da‐Silva Journal of Computational Chemistry, 2012 | 60 | 2012 |
| Structural Model of the Fe-Hydrogenase/Cytochromec 553 Complex Combining Transverse Relaxation-optimized Spectroscopy Experiments and Soft Docking Calculations X Morelli, M Czjzek, CE Hatchikian, O Bornet, JC Fontecilla-Camps, ... Journal of Biological Chemistry 275 (30), 23204-23210, 2000 | 58 | 2000 |
| Synthesis, biological evaluation, and molecular modeling studies of a novel, peripherally selective inhibitor of catechol-O-methyltransferase DA Learmonth, PN Palma, MA Vieira-Coelho, P Soares-da-Silva Journal of medicinal chemistry 47 (25), 6207-6217, 2004 | 55 | 2004 |
| Molecular modeling and metabolic studies of the interaction of catechol-O-methyltransferase and a new nitrocatechol inhibitor PN Palma, MJ Bonifácio, AI Loureiro, LC Wright, DA Learmonth, ... Drug metabolism and disposition 31 (3), 250-258, 2003 | 50 | 2003 |
| The structure of an electron transfer complex containing a cytochrome c and a peroxidase GW Pettigrew, S Prazeres, C Costa, N Palma, L Krippahl, I Moura, ... Journal of Biological Chemistry 274 (16), 11383-11389, 1999 | 43 | 1999 |
| Ferredoxins JJG Moura, AL Macedo, P Nuno Palma Methods in enzymology 243, 165-188, 1994 | 39* | 1994 |
| Evidence for a ternary complex formed between flavodoxin and cytochrome c3: 1H-NMR and molecular modeling studies PN Palma, I Moura, J LeGall, J Van Beeumen, JE Wampler, JJG Moura Biochemistry 33 (21), 6394-6407, 1994 | 38 | 1994 |
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