| A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. P Samama, S Cotecchia, T Costa, RJ Lefkowitz Journal of Biological Chemistry 268 (7), 4625-4636, 1993 | 1626 | 1993 |
| Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins RJ Lefkowitz, S Cotecchia, P Samama, T Costa Trends in pharmacological sciences 14 (8), 303-307, 1993 | 1041 | 1993 |
| Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins. T Costa, A Herz Proceedings of the National Academy of Sciences 86 (19), 7321-7325, 1989 | 698 | 1989 |
| Constitutively active mutants of the alpha 1B‐adrenergic receptor: role of highly conserved polar amino acids in receptor activation. A Scheer, F Fanelli, T Costa, PG De Benedetti, S Cotecchia The EMBO Journal 15 (14), 3566-3578, 1996 | 480 | 1996 |
| Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation DP Staus, RT Strachan, A Manglik, B Pani, AW Kahsai, TH Kim, ... Nature 535 (7612), 448-452, 2016 | 339 | 2016 |
| Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor. P Samama, G Pei, T Costa, S Cotecchia, RJ Lefkowitz Molecular pharmacology 45 (3), 390-394, 1994 | 306 | 1994 |
| Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: thermodynamic interpretation of negative antagonism and of receptor activity in the absence of … T Costa, Y Ogino, PJ Munson, HO Onaran, D Rodbard Molecular Pharmacology 41 (3), 549-560, 1992 | 306 | 1992 |
| Timing of surgery following SARS‐CoV‐2 infection: an international prospective cohort study COVIDSurg Collaborative, GlobalSurg Collaborative, D Nepogodiev, ... Anaesthesia 76 (6), 748-758, 2021 | 283 | 2021 |
| The activation process of the α1B-adrenergic receptor: Potential role of protonation and hydrophobicity of a highly conserved aspartate A Scheer, F Fanelli, T Costa, PG De Benedetti, S Cotecchia Proceedings of the National Academy of Sciences 94 (3), 808-813, 1997 | 270 | 1997 |
| Is the benzodiazepine receptor coupled to a chloride anion channel? T Costa, D Rodbard, CB PERT Nature 277 (5694), 315-317, 1979 | 249 | 1979 |
| Spontaneous association between opioid receptors and GTP-binding regulatory proteins in native membranes: specific regulation by antagonists and sodium ions. T Costa, J Lang, C Gless, A Herz Molecular pharmacology 37 (3), 383-394, 1990 | 177 | 1990 |
| Historical review: Negative efficacy and the constitutive activity of G-protein-coupled receptors T Costa, S Cotecchia Trends in pharmacological sciences 26 (12), 618-624, 2005 | 169 | 2005 |
| Mutational analysis of the highly conserved arginine within the Glu/Asp-Arg-Tyr motif of the α1b-adrenergic receptor: effects on receptor isomerization and activation A Scheer, T Costa, F Fanelli, PG De Benedetti, S Mhaouty-Kodja, L Abuin, ... Molecular pharmacology 57 (2), 219-231, 2000 | 149 | 2000 |
| Dimeric tetrapeptide enkephalins display extraordinary selectivity for the δ opiate receptor Y Shimohigashi, T Costa, HC Chen, D Rodbard Nature 297 (5864), 333-335, 1982 | 140 | 1982 |
| Opiate receptor binding sites in human spinal cord A Członkowski, T Costa, R Przewłocki, A Pasi, A Herz Brain Research 267 (2), 392-396, 1983 | 137 | 1983 |
| Morphine-like opiates selectively antagonize receptor-arrestin interactions P Molinari, V Vezzi, M Sbraccia, C Grò, D Riitano, C Ambrosio, I Casella, ... Journal of biological chemistry 285 (17), 12522-12535, 2010 | 134 | 2010 |
| Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR) RT Strachan, J Sun, DH Rominger, JD Violin, S Ahn, ARB Thomsen, ... Journal of Biological Chemistry 289 (20), 14211-14224, 2014 | 132 | 2014 |
| Thrombin is a regulator of astrocytic endothelin-1 H Ehrenreich, T Costa, KA Clouse, RM Pluta, Y Ogino, JE Coligan, ... Brain research 600 (2), 201-207, 1993 | 127 | 1993 |
| Agonist Efficacy and Aliosteric Models of Receptor Actiona HO Onaran, T Costa Annals of the new York Academy of Sciences 812 (1), 98-115, 1997 | 116 | 1997 |
| Highly potent nociceptin analog containing the Arg-Lys triple repeat K Okada, T Sujaku, Y Chuman, R Nakashima, T Nose, T Costa, ... Biochemical and biophysical research communications 278 (2), 493-498, 2000 | 113 | 2000 |
Robert J. LefkowitzJames B. Duke Professor of Medicine, Biochemistry, Chemistry; HHMI, Duke University在 receptor-biol.duke.edu 的电子邮件经过验证
