关注
Brendan R. Amer
Brendan R. Amer
Senior Scientist, Amgen
在 amgen.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
Discovery of Staphylococcus aureus Sortase A Inhibitors Using Virtual Screening and the Relaxed Complex Scheme
AH Chan, J Wereszczynski, BR Amer, SW Yi, ME Jung, JA McCammon, ...
Chemical biology & drug design 82 (4), 418-428, 2013
762013
Dimer interface of the effector domain of non-structural protein 1 from influenza A virus an interface with multiple functions
JM Aramini, LC Ma, L Zhou, CM Schauder, K Hamilton, BR Amer, ...
Journal of Biological Chemistry 286 (29), 26050-26060, 2011
702011
Structural basis for the sequence-specific recognition of human ISG15 by the NS1 protein of influenza B virus
R Guan, LC Ma, PG Leonard, BR Amer, H Sridharan, C Zhao, RM Krug, ...
Proceedings of the National Academy of Sciences 108 (33), 13468-13473, 2011
622011
Designed Protein Cages as Scaffolds for Building Multi-Enzyme Materials
SA McConnell, KA Cannon, C Morgan, R McAllister, BR Amer, RT Clubb, ...
ACS Synthetic Biology, 2020
602020
Structural and computational studies of the Staphylococcus aureus sortase B-substrate complex reveal a substrate-stabilized oxyanion hole
AW Jacobitz, J Wereszczynski, SW Yi, BR Amer, GL Huang, AV Nguyen, ...
Journal of Biological Chemistry 289 (13), 8891-8902, 2014
532014
Human COQ10A and COQ10B are distinct lipid-binding START domain proteins required for coenzyme Q function
HS Tsui, NVB Pham, BR Amer, MC Bradley, JE Gosschalk, ...
Journal of lipid research 60 (7), 1293-1310, 2019
472019
Protein Labeling via a Specific Lysine-Isopeptide Bond Using the Pilin Polymerizing Sortase from Corynebacterium diphtheriae
SA McConnell, BR Amer, J Muroski, J Fu, C Chang, RR Ogorzalek Loo, ...
Journal of the American Chemical Society 140 (27), 8420-8423, 2018
352018
In vitro reconstitution of sortase-catalyzed pilus polymerization reveals structural elements involved in pilin cross-linking
C Chang, BR Amer, J Osipiuk, SA McConnell, IH Huang, V Hsieh, J Fu, ...
Proceedings of the National Academy of Sciences 115 (24), E5477-E5486, 2018
262018
NMR structure‐based optimization of Staphylococcus aureus sortase A pyridazinone inhibitors
AH Chan, SW Yi, EM Weiner, BR Amer, CK Sue, J Wereszczynski, ...
Chemical biology & drug design 90 (3), 327-344, 2017
252017
Structure and mechanism of LcpA, a phosphotransferase that mediates glycosylation of a Gram-positive bacterial cell wall-anchored protein
SD Siegel, BR Amer, C Wu, MR Sawaya, JE Gosschalk, RT Clubb, ...
MBio 10 (1), e01580-18, 2019
242019
Rapid addition of unlabeled silent solubility tags to proteins using a new substrate-fused sortase reagent
BR Amer, R Macdonald, AW Jacobitz, B Liauw, RT Clubb
Journal of biomolecular NMR 64 (3), 197-205, 2016
112016
A sweet new role for LCP enzymes in protein glycosylation
BR Amer, RT Clubb
Molecular microbiology 94 (6), 1197-1200, 2014
102014
Solution structure of the PhoP DNA-binding domain from Mycobacterium tuberculosis
R Macdonald, D Sarkar, BR Amer, RT Clubb
Journal of biomolecular NMR 63 (1), 111-117, 2015
22015
Methods and compositions to increase the rate of ligation reactions catalyzed by a sortase
RT Clubb, BR Amer
US Patent App. 16/072,155, 2019
2019
Human COQ10A and COQ10B are distinct putative StART domain proteins that restore Q biosynthesis and function in yeast
HS Tsui, NV Pham, L Fernández-Del-Río, BR Amer, MC Bradley, ...
The FASEB Journal 32 (1_supplement), 672.7-672.7, 2018
2018
Molecular Level Insight into a Unique Surface Protein Glycosylation Pathway: Structure of the Actinomyces Oris LCP Enzyme that Mediates Surface Protein Glycosylation
BR Amer, MR Sawaya, B Liauw, J Fu, H Ton-That, RT Clubb
Biophysical Journal 112 (3), 344a, 2017
2017
Structural and Biochemical Investigation of Gram-Positive Bacterial Surface Display Machinery
BR Amer
UCLA, 2017
2017
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