HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase DC Goldstone, V Ennis-Adeniran, JJ Hedden, HCT Groom, GI Rice, ... Nature 480 (7377), 379-382, 2011 | 968 | 2011 |
Structure and functions of the GNAT superfamily of acetyltransferases MW Vetting, LPS de Carvalho, M Yu, SS Hegde, S Magnet, SL Roderick, ... Archives of biochemistry and biophysics 433 (1), 212-226, 2005 | 683 | 2005 |
Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates LPS de Carvalho, SM Fischer, J Marrero, C Nathan, S Ehrt, KY Rhee Chemistry & biology 17 (10), 1122-1131, 2010 | 401 | 2010 |
Inhibitors selective for mycobacterial versus human proteasomes G Lin, D Li, LPS De Carvalho, H Deng, H Tao, G Vogt, K Wu, J Schneider, ... Nature 461 (7264), 621-626, 2009 | 240 | 2009 |
Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier KY Rhee, LPS De Carvalho, R Bryk, S Ehrt, J Marrero, SW Park, ... Trends in microbiology 19 (7), 307-314, 2011 | 203 | 2011 |
Mycobacterium tuberculosis Exploits Asparagine to Assimilate Nitrogen and Resist Acid Stress during Infection A Gouzy, G Larrouy-Maumus, D Bottai, F Levillain, A Dumas, JB Wallach, ... PLoS Pathogens 10 (2), e1003928, 2014 | 163 | 2014 |
Nitazoxanide Kills Replicating and Nonreplicating Mycobacterium tuberculosis and Evades Resistance LPS de Carvalho, G Lin, X Jiang, C Nathan Journal of medicinal chemistry 52 (19), 5789-5792, 2009 | 144 | 2009 |
Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis LPS de Carvalho, CM Darby, KY Rhee, C Nathan ACS medicinal chemistry letters 2 (11), 849-854, 2011 | 138 | 2011 |
Metabolomic strategies for the identification of new enzyme functions and metabolic pathways GA Prosser, G Larrouy‐Maumus, LPS de Carvalho EMBO reports 15 (6), 657-669, 2014 | 131 | 2014 |
Kinetic mechanism and inhibition of Mycobacterium tuberculosis d‐alanine:d‐alanine ligase by the antibiotic d‐cycloserine GA Prosser, LPS de Carvalho The FEBS journal 280 (4), 1150-1166, 2013 | 131 | 2013 |
Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase LPS de Carvalho, H Zhao, CE Dickinson, NM Arango, CD Lima, ... Chemistry & biology 17 (4), 323-332, 2010 | 123 | 2010 |
Metabolomics Reveal d-Alanine:d-Alanine Ligase As the Target of d-Cycloserine in Mycobacterium tuberculosis GA Prosser, LPS de Carvalho ACS medicinal chemistry letters 4 (12), 1233-1237, 2013 | 112 | 2013 |
Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate A Gouzy, G Larrouy-Maumus, TD Wu, A Peixoto, F Levillain, ... Nature Chemical Biology 9 (11), 674-676, 2013 | 98 | 2013 |
Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism A Serafini, L Tan, S Horswell, S Howell, DJ Greenwood, DM Hunt, ... Molecular microbiology 112 (4), 1284-1307, 2019 | 96 | 2019 |
Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite WL Lee, B Gold, C Darby, N Brot, X Jiang, LPS De Carvalho, D Wellner, ... Molecular microbiology 71 (3), 583-593, 2009 | 89 | 2009 |
Inhibition of D-Ala: D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine S Batson, C de Chiara, V Majce, AJ Lloyd, S Gobec, D Rea, V Fülöp, ... Nature communications 8 (1), 1939, 2017 | 81 | 2017 |
Thiophenecarboxamide derivatives activated by EthA kill Mycobacterium tuberculosis by inhibiting the CTP synthetase PyrG G Mori, LR Chiarelli, M Esposito, V Makarov, M Bellinzoni, RC Hartkoorn, ... Chemistry & biology 22 (7), 917-927, 2015 | 78 | 2015 |
Biosynthesis and translocation of unsulfated acyltrehaloses in Mycobacterium tuberculosis JM Belardinelli, G Larrouy-Maumus, V Jones, LPS de Carvalho, ... Journal of Biological Chemistry 289 (40), 27952-27965, 2014 | 76 | 2014 |
An NAD+ phosphorylase toxin triggers Mycobacterium tuberculosis cell death DM Freire, C Gutierrez, A Garza-Garcia, AD Grabowska, AJ Sala, ... Molecular cell 73 (6), 1282-1291. e8, 2019 | 69 | 2019 |
A philosophy of anti-infectives as a guide in the search for new drugs for tuberculosis C Nathan, B Gold, G Lin, M Stegman, LPS de Carvalho, O Vandal, ... Tuberculosis 88, S25-S33, 2008 | 68 | 2008 |