| A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes ME MacDonald, CM Ambrose, MP Duyao, RH Myers, C Lin, L Srinidhi, ... Cell 72 (6), 971-983, 1993 | 2199 | 1993 |
| Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia R Shiang, LM Thompson, YZ Zhu, DM Church, TJ Fielder, M Bocian, ... Cell 78 (2), 335-342, 1994 | 1599 | 1994 |
| Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila JS Steffan, L Bodai, J Pallos, M Poelman, A McCampbell, BL Apostol, ... Nature 413 (6857), 739-743, 2001 | 1455 | 2001 |
| The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription JS Steffan, A Kazantsev, O Spasic-Boskovic, M Greenwald, YZ Zhu, ... Proceedings of the National Academy of Sciences 97 (12), 6763-6768, 2000 | 1268 | 2000 |
| Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease E Hockly, VM Richon, B Woodman, DL Smith, X Zhou, E Rosa, ... Proceedings of the National Academy of Sciences 100 (4), 2041-2046, 2003 | 1055 | 2003 |
| SUMO modification of Huntingtin and Huntington's disease pathology JS Steffan, N Agrawal, J Pallos, E Rockabrand, LC Trotman, N Slepko, ... Science 304 (5667), 100-104, 2004 | 892 | 2004 |
| Therapeutic application of histone deacetylase inhibitors for central nervous system disorders AG Kazantsev, LM Thompson Nature reviews Drug discovery 7 (10), 854-868, 2008 | 868 | 2008 |
| Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3 PL Tavormina, R Shiang, LM Thompson, YZ Zhu, DJ Wilkin, RS Lachman, ... Nature genetics 9 (3), 321-328, 1995 | 688 | 1995 |
| Genome-wide analyses identify KIF5A as a novel ALS gene A Nicolas, KP Kenna, AE Renton, N Ticozzi, F Faghri, R Chia, ... Neuron 97 (6), 1267-1288, 2018 | 595 | 2018 |
| Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes Hd iPsc Consortium Cell stem cell 11 (2), 264-278, 2012 | 495 | 2012 |
| Green tea (−)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models DE Ehrnhoefer, M Duennwald, P Markovic, JL Wacker, S Engemann, ... Human molecular genetics 15 (18), 2743-2751, 2006 | 473 | 2006 |
| Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau KN Green, JS Steffan, H Martinez-Coria, X Sun, SS Schreiber, ... Journal of Neuroscience 28 (45), 11500-11510, 2008 | 463 | 2008 |
| IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome LM Thompson, CT Aiken, LS Kaltenbach, N Agrawal, K Illes, A Khoshnan, ... Journal of Cell Biology 187 (7), 1083-1099, 2009 | 438 | 2009 |
| The library of integrated network-based cellular signatures NIH program: system-level cataloging of human cells response to perturbations AB Keenan, SL Jenkins, KM Jagodnik, S Koplev, E He, D Torre, Z Wang, ... Cell systems 6 (1), 13-24, 2018 | 395 | 2018 |
| SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis R Luthi-Carter, DM Taylor, J Pallos, E Lambert, A Amore, A Parker, ... Proceedings of the National Academy of Sciences 107 (17), 7927-7932, 2010 | 391 | 2010 |
| Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice X Gu, ER Greiner, R Mishra, R Kodali, A Osmand, S Finkbeiner, ... Neuron 64 (6), 828-840, 2009 | 359 | 2009 |
| A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo X Zhang, DL Smith, AB Meriin, S Engemann, DE Russel, M Roark, ... Proceedings of the national academy of sciences 102 (3), 892-897, 2005 | 327 | 2005 |
| The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis E Rockabrand, N Slepko, A Pantalone, VN Nukala, A Kazantsev, ... Human molecular genetics 16 (1), 61-77, 2007 | 326 | 2007 |
| Mutant huntingtin disrupts the nuclear pore complex JC Grima, JG Daigle, N Arbez, KC Cunningham, KE Zhang, J Ochaba, ... Neuron 94 (1), 93-107. e6, 2017 | 325 | 2017 |
| Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease J Pallos, L Bodai, T Lukacsovich, JM Purcell, JS Steffan, LM Thompson, ... Human molecular genetics 17 (23), 3767-3775, 2008 | 317 | 2008 |
