| Bcl-2 functionally interacts with inositol 1, 4, 5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1, 4, 5-trisphosphate R Chen, I Valencia, F Zhong, KS McColl, HL Roderick, MD Bootman, ... The Journal of cell biology 166 (2), 193-203, 2004 | 486 | 2004 |
| 2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1, 4, 5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible … CM Peppiatt, TJ Collins, L Mackenzie, SJ Conway, AB Holmes, ... Cell Calcium 34 (1), 97-108, 2003 | 345 | 2003 |
| Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains DA Hay, O Fedorov, S Martin, DC Singleton, C Tallant, C Wells, S Picaud, ... Journal of the American Chemical Society 136 (26), 9308-9319, 2014 | 334 | 2014 |
| 3, 5-Dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands DS Hewings, M Wang, M Philpott, O Fedorov, S Uttarkar, ... Journal of medicinal chemistry 54 (19), 6761-6770, 2011 | 257 | 2011 |
| Progress in the Development and Application of Small Molecule Inhibitors of Bromodomain–Acetyl-lysine Interactions DS Hewings, TPC Rooney, LE Jennings, DA Hay, CJ Schofield, ... Journal of Medicinal Chemistry 55 (22), 9393-9413, 2012 | 216 | 2012 |
| The use of phosphate bioisosteres in medicinal chemistry and chemical biology TS Elliott, A Slowey, Y Ye, SJ Conway MedChemComm 3 (7), 735-751, 2012 | 206 | 2012 |
| Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins AM Holmes, MD Bootman, K Rietdorf, F McDonald, SJ Conway, ... The EMBO journal 23 (2), 312-21, 2004 | 186 | 2004 |
| The spatial pattern of atrial cardiomyocyte calcium signalling modulates contraction L Mackenzie, HL Roderick, MJ Berridge, SJ Conway, MD Bootman Journal of cell science 117 (26), 6327-6337, 2004 | 174 | 2004 |
| Small molecule inhibitors of bromodomain–acetyl-lysine interactions M Brand, AM Measures, BG Wilson, WA Cortopassi, R Alexander, ... ACS chemical biology 10 (1), 22-39, 2015 | 161 | 2015 |
| Optimization of 3, 5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands DS Hewings, O Fedorov, P Filippakopoulos, S Martin, S Picaud, A Tumber, ... Journal of medicinal chemistry 56 (8), 3217-3227, 2013 | 161 | 2013 |
| Clinical advances of hypoxia-activated prodrugs in combination with radiation therapy IN Mistry, M Thomas, EDD Calder, SJ Conway, EM Hammond International Journal of Radiation Oncology• Biology• Physics 98 (5), 1183-1196, 2017 | 152 | 2017 |
| Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy D Harzheim, M Movassagh, RSY Foo, O Ritter, A Tashfeen, SJ Conway, ... Proceedings of the National Academy of Sciences 106 (27), 11406-11411, 2009 | 152 | 2009 |
| NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing LC Davis, AJ Morgan, JL Chen, CM Snead, D Bloor-Young, E Shenderov, ... Current Biology 22 (24), 2331-2337, 2012 | 151 | 2012 |
| Inositol 1, 4, 5-trisphosphate supports the arrhythmogenic action of endothelin-1 on ventricular cardiac myocytes A Proven, HL Roderick, SJ Conway, MJ Berridge, JK Horton, SJ Capper, ... Journal of cell science 119 (16), 3363-3375, 2006 | 142 | 2006 |
| A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced‐Fit Pocket Stabilized by a Cation–π Interaction TPC Rooney, P Filippakopoulos, O Fedorov, S Picaud, WA Cortopassi, ... Angewandte Chemie International Edition 53 (24), 6126-6130, 2014 | 131 | 2014 |
| Engineering transkingdom signalling in plants to control gene expression in rhizosphere bacteria BA Geddes, P Paramasivan, A Joffrin, AL Thompson, K Christensen, ... Nature Communications 10 (1), 3430, 2019 | 129 | 2019 |
| The proapoptotic factors Bax and Bak regulate T cell proliferation through control of endoplasmic reticulum Ca 2+ homeostasis RG Jones, T Bui, C White, M Madesh, CM Krawczyk, T Lindsten, ... Immunity 27 (2), 268-280, 2007 | 124 | 2007 |
| The consequences of mitochondrial amyloid β-peptide in Alzheimer's disease KEA Muirhead, E Borger, L Aitken, SJ Conway, FJ Gunn-Moore Biochemical Journal 426 (3), 255-270, 2010 | 108 | 2010 |
| The design and synthesis of 5-and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains D Hay, O Fedorov, P Filippakopoulos, S Martin, M Philpott, S Picaud, ... MedChemComm 4 (1), 140-144, 2013 | 92 | 2013 |
| Mechanism of ligand-gated potassium efflux in bacterial pathogens (vol 107, pg 19785, 2010) TP Roosild, S Castronovo, J Healy, S Miller, C Pliotas, T Rasmussen, ... PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF …, 2014 | 89* | 2014 |
Martin Bootmancambridge在 open.ac.uk 的电子邮件经过验证
