| Nitrogen‐containing bisphosphonates inhibit the mevalonate pathway and prevent post‐translational prenylation of GTP‐binding proteins, including Ras SP Luckman, DE Hughes, FP Coxon, RGG Russell, MJ Dr. Rogers Journal of bone and mineral research 13 (4), 581-589, 1998 | 1555 | 1998 |
| Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo DE Hughes, KR Wright, HL Uy, A Sasaki, T Yoneda, DG Roodman, ... Journal of Bone and Mineral Research 10 (10), 1478-1487, 1995 | 1331 | 1995 |
| Estrogen promotes apoptosis of murine osteoclasts mediated by TGF–β DE Hughes, A Dai, JC Tiffee, HH Li, GR Mundy, BF Boyce Nature medicine 2 (10), 1132-1136, 1996 | 1183 | 1996 |
| Angiosarcoma RJ Young, NJ Brown, MW Reed, D Hughes, PJ Woll The lancet oncology 11 (10), 983-991, 2010 | 983 | 2010 |
| Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation … JE Fisher, MJ Rogers, JM Halasy, SP Luckman, DE Hughes, ... Proceedings of the National Academy of Sciences 96 (1), 133-138, 1999 | 935 | 1999 |
| Inhibition of osteoclast-like cell formation by bisphosphonates in long-term cultures of human bone marrow. DE Hughes, BR MacDonald, RG Russell, M Gowen The Journal of clinical investigation 83 (6), 1930-1935, 1989 | 487 | 1989 |
| Theoretical perspective: A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates AM Parfitt, GR Mundy, GD Roodman, DE Hughes, BF Boyce Journal of Bone and Mineral Research 11 (2), 150-159, 1996 | 449 | 1996 |
| Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene MJH Nicklin, DE Hughes, JL Barton, JM Ure, GW Duff The Journal of experimental medicine 191 (2), 303-312, 2000 | 392 | 2000 |
| Integrin expression in human bone DE Hughes, DM Salter, S Dedhar, R Simpson Journal of bone and mineral research 8 (5), 527-533, 1993 | 311 | 1993 |
| Fulminating fat embolism syndrome caused by paradoxical embolism through a patent foramen ovale ACH Pell, D Hughes, J Keating, J Christie, A Busuttil, GR Sutherland New England Journal of Medicine 329 (13), 926-929, 1993 | 291 | 1993 |
| Integrin expression by human articular chondrocytes DM Salter, DE Hughes, R Simpson, DL Gardner Rheumatology 31 (4), 231-234, 1992 | 228 | 1992 |
| Recent advances in bone biology provide insight into the pathogenesis of bone diseases. BF Boyce, DE Hughes, KR Wright, L Xing, A Dai Laboratory investigation; a journal of technical methods and pathology 79 (2 …, 1999 | 226 | 1999 |
| The effects of cytokines and growth factors on osteoblastic cells GR Mundy, B Boyce, D Hughes, K Wright, L Bonewald, S Dallas, S Harris, ... Bone 17 (2), S71-S75, 1995 | 205 | 1995 |
| The Modulation of the Expression of IL-6 and Its Receptor in Human Osteoblasts in Vitro AJ Littlewood, J Russell, GR Harvey, DE Hughes, RGG Russell, M Gowen Endocrinology 129 (3), 1513-1520, 1991 | 205 | 1991 |
| Apoptosis in bone physiology and disease. DE Hughes, BF Boyce Molecular Pathology 50 (3), 132, 1997 | 163 | 1997 |
| Production of tumor necrosis factor by human osteoblasts is modulated by other cytokines, but not by osteotropic hormones M GOWEN, K CHAPMAN, A LITTLEWOOD, D HUGHES, D EVANS, ... Endocrinology 126 (2), 1250-1255, 1990 | 148 | 1990 |
| CD44 expression in human bone: a novel marker of osteocytic differentiation DE Hughes, DM Salter, R Simpson Journal of Bone and Mineral Research 9 (1), 39-44, 1994 | 124 | 1994 |
| Interleukin‐6 does not stimulate bone resorption in neonatal mouse calvariae A Al‐Humidan, SH Ralston, DE Hughes, K Chapman, L Aarden, ... Journal of Bone and Mineral Research 6 (1), 3-8, 1991 | 122 | 1991 |
| Analysis of human articular chondrocyte CD44 isoform expression and function in health and disease DM Salter, JL Godolphin, MS Gourlay, MF Lawson, DE Hughes, E Dunne The Journal of pathology 179 (4), 396-402, 1996 | 64 | 1996 |
| Constitutive and inducible expression of HLA class II determinants by human osteoblast-like cells in vitro. H Skjødt, DE Hughes, PR Dobson, RG Russell The Journal of clinical investigation 85 (5), 1421-1426, 1990 | 64 | 1990 |
