Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v. 3.0 L Heirendt, S Arreckx, T Pfau, SN Mendoza, A Richelle, A Heinken, ... Nature protocols 14 (3), 639-702, 2019 | 1063 | 2019 |
MEMOTE for standardized genome-scale metabolic model testing C Lieven, ME Beber, BG Olivier, FT Bergmann, M Ataman, P Babaei, ... Nature biotechnology 38 (3), 272-276, 2020 | 370 | 2020 |
A systematic evaluation of methods for tailoring genome-scale metabolic models S Opdam, A Richelle, B Kellman, S Li, DC Zielinski, NE Lewis Cell systems 4 (3), 318-329. e6, 2017 | 217 | 2017 |
Increasing consensus of context-specific metabolic models by integrating data-inferred cell functions A Richelle, AWT Chiang, CC Kuo, NE Lewis PLoS computational biology 15 (4), e1006867, 2019 | 75 | 2019 |
Assessing key decisions for transcriptomic data integration in biochemical networks A Richelle, C Joshi, NE Lewis PLoS computational biology 15 (7), e1007185, 2019 | 70 | 2019 |
Memote: A community driven effort towards a standardized genome-scale metabolic model test suite C Lieven, ME Beber, BG Olivier, FT Bergmann, M Ataman, P Babaei, ... BioRxiv, 350991, 2018 | 59 | 2018 |
Improvements in protein production in mammalian cells from targeted metabolic engineering A Richelle, NE Lewis Current opinion in systems biology 6, 1-6, 2017 | 44 | 2017 |
When is an in silico representation a digital twin? A biopharmaceutical industry approach to the digital twin concept RMC Portela, C Varsakelis, A Richelle, N Giannelos, J Pence, S Dessoy, ... Digital Twins: Tools and Concepts for Smart Biomanufacturing, 35-55, 2021 | 42 | 2021 |
Linear robust control of S. cerevisiae fed-batch cultures at different scales L Dewasme, A Richelle, P Dehottay, P Georges, M Remy, P Bogaerts, ... Biochemical engineering journal 53 (1), 26-37, 2010 | 42 | 2010 |
Elucidating Human Milk Oligosaccharide biosynthetic genes through network-based multi-omics integration BP Kellman, A Richelle, JY Yang, D Chapla, AWT Chiang, JA Najera, ... Nature communications 13 (1), 2455, 2022 | 41 | 2022 |
Model-based assessment of mammalian cell metabolic functionalities using omics data A Richelle, BP Kellman, AT Wenzel, AWT Chiang, T Reagan, ... Cell reports methods 1 (3), 2021 | 32* | 2021 |
StanDep: Capturing transcriptomic variability improves context-specific metabolic models CJ Joshi, SM Schinn, A Richelle, I Shamie, EJ O’Rourke, NE Lewis PLoS computational biology 16 (5), e1007764, 2020 | 29 | 2020 |
Modulating carbohydrate–protein interactions through glycoengineering of monoclonal antibodies to impact cancer physiology AWT Chiang, S Li, PN Spahn, A Richelle, CC Kuo, M Samoudi, NE Lewis Current opinion in structural biology 40, 104-111, 2016 | 29 | 2016 |
Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3 JC Granados, A Richelle, JM Gutierrez, P Zhang, X Zhang, V Bhatnagar, ... Journal of Biological Chemistry 296, 2021 | 27 | 2021 |
Dynamic resource allocation drives growth under nitrogen starvation in eukaryotes JD Tibocha-Bonilla, M Kumar, A Richelle, RD Godoy-Silva, K Zengler, ... NPJ systems biology and applications 6 (1), 14, 2020 | 25 | 2020 |
Systematic methodology for bioprocess model identification based on generalized kinetic functions A Richelle, P Bogaerts Biochemical engineering journal 100, 41-49, 2015 | 22 | 2015 |
Macroscopic modelling of baker's yeast production in fed-batch cultures and its link with trehalose production A Richelle, P Fickers, P Bogaerts Computers & chemical engineering 61, 220-233, 2014 | 21 | 2014 |
Towards a widespread adoption of metabolic modeling tools in biopharmaceutical industry: a process systems biology engineering perspective A Richelle, B David, D Demaegd, M Dewerchin, R Kinet, A Morreale, ... NPJ systems biology and applications 6 (1), 6, 2020 | 19 | 2020 |
From MFA to FBA: Defining linear constraints accounting for overflow metabolism in a macroscopic FBA-based dynamical model of cell cultures in bioreactor P Bogaerts, KM Gziri, A Richelle Journal of Process Control 60, 34-47, 2017 | 17 | 2017 |
A methodology for building a macroscopic FBA-based dynamical simulator of cell cultures through flux variability analysis A Richelle, KM Gziri, P Bogaerts Biochemical engineering journal 114, 50-64, 2016 | 13 | 2016 |