| Folding of newly translated proteins in vivo: the role of molecular chaperones J Frydman Annual review of biochemistry 70 (1), 603-647, 2001 | 1532 | 2001 |
| Misfolded proteins partition between two distinct quality control compartments D Kaganovich, R Kopito, J Frydman Nature 454 (7208), 1088-1095, 2008 | 1061 | 2008 |
| Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones J Frydman, E Nimmesgern, K Ohtsuka, FU Hartl Nature 370 (6485), 111-117, 1994 | 878 | 1994 |
| Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches AJ McClellan, Y Xia, AM Deutschbauer, RW Davis, M Gerstein, J Frydman Cell 131 (1), 121-135, 2007 | 582 | 2007 |
| Protein misfolding in neurodegenerative diseases: implications and strategies P Sweeney, H Park, M Baumann, J Dunlop, J Frydman, R Kopito, ... Translational neurodegeneration 6, 1-13, 2017 | 579 | 2017 |
| Cellular strategies of protein quality control B Chen, M Retzlaff, T Roos, J Frydman Cold Spring Harbor perspectives in biology 3 (8), a004374, 2011 | 548 | 2011 |
| Evolutionary conservation of codon optimality reveals hidden signatures of cotranslational folding S Pechmann, J Frydman Nature structural & molecular biology 20 (2), 237-243, 2013 | 547 | 2013 |
| Function in protein folding of TRiC, a cytosolic ring complex containing TCP‐1 and structurally related subunits. J Frydman, E Nimmesgern, H Erdjument‐Bromage, JS Wall, P Tempst, ... The EMBO journal 11 (13), 4767-4778, 1992 | 505 | 1992 |
| Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets C Spiess, AS Meyer, S Reissmann, J Frydman Trends in cell biology 14 (11), 598-604, 2004 | 456 | 2004 |
| Systematic functional prioritization of protein posttranslational modifications P Beltrao, V Albanèse, LR Kenner, DL Swaney, A Burlingame, J Villén, ... Cell 150 (2), 413-425, 2012 | 441 | 2012 |
| Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies AY Yam, Y Xia, HTJ Lin, A Burlingame, M Gerstein, J Frydman Nature structural & molecular biology 15 (12), 1255-1262, 2008 | 436 | 2008 |
| Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging DS Leeman, K Hebestreit, T Ruetz, AE Webb, A McKay, EA Pollina, ... Science 359 (6381), 1277-1283, 2018 | 421 | 2018 |
| In vivo newly translated polypeptides are sequestered in a protected folding environment V Thulasiraman, CF Yang, J Frydman The EMBO journal, 1999 | 416 | 1999 |
| The role of mutational robustness in RNA virus evolution AS Lauring, J Frydman, R Andino Nature Reviews Microbiology 11 (5), 327-336, 2013 | 409 | 2013 |
| Chaperones get in touch: the Hip-Hop connection J Frydman, J Höhfeld Trends in biochemical sciences 22 (3), 87-92, 1997 | 367 | 1997 |
| The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions S Tam, R Geller, C Spiess, J Frydman Nature cell biology 8 (10), 1155-1162, 2006 | 363 | 2006 |
| Principles of chaperone-assisted protein folding: differences between in vitro and in vivo mechanisms J Frydman, FU Hartl Science 272 (5267), 1497-1502, 1996 | 363 | 1996 |
| Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress S Escusa-Toret, WIM Vonk, J Frydman Nature cell biology 15 (10), 1231-1243, 2013 | 358 | 2013 |
| Protein quality control: chaperones culling corrupt conformations AJ McClellan, S Tam, D Kaganovich, J Frydman Nature cell biology 7 (8), 736-741, 2005 | 347 | 2005 |
| Systems analyses reveal two chaperone networks with distinct functions in eukaryotic cells V Albanese, AYW Yam, J Baughman, C Parnot, J Frydman Cell 124 (1), 75-88, 2006 | 319 | 2006 |
