Enrichment-triggered prodrug activation demonstrated through mitochondria-targeted delivery of doxorubicin and carbon monoxide Y Zheng, X Ji, B Yu, K Ji, D Gallo, E Csizmadia, M Zhu, MR Choudhury, ... Nature chemistry 10 (7), 787-794, 2018 | 247 | 2018 |
Click and release: bioorthogonal approaches to “on-demand” activation of prodrugs X Ji, Z Pan, B Yu, LK De La Cruz, Y Zheng, B Ke, B Wang Chemical Society Reviews 48 (4), 1077-1094, 2019 | 243 | 2019 |
Esterase‐sensitive prodrugs with tunable release rates and direct generation of hydrogen sulfide Y Zheng, B Yu, K Ji, Z Pan, V Chittavong, B Wang Angewandte Chemie International Edition 55 (14), 4514-4518, 2016 | 180 | 2016 |
Click and release: a chemical strategy toward developing gasotransmitter prodrugs by using an intramolecular Diels–Alder reaction X Ji, C Zhou, K Ji, RE Aghoghovbia, Z Pan, V Chittavong, B Ke, B Wang Angewandte Chemie International Edition 55 (51), 15846-15851, 2016 | 148 | 2016 |
pH-Sensitive metal-free carbon monoxide prodrugs with tunable and predictable release rates X Ji, LKC De La Cruz, Z Pan, V Chittavong, B Wang Chemical Communications 53 (69), 9628-9631, 2017 | 72 | 2017 |
Organic CO‐prodrugs: Structure CO‐release rate relationship Studies Z Pan, X Ji, V Chittavong, W Li, K Ji, M Zhu, J Zhang, B Wang Chemistry-A European Journal, 2017 | 71 | 2017 |
An esterase-activated click and release approach to metal-free CO-prodrugs X Ji, K Ji, V Chittavong, B Yu, Z Pan, B Wang Chemical Communications 53 (59), 8296-8299, 2017 | 71 | 2017 |
Esterase-sensitive and pH-controlled carbon monoxide prodrugs for treating systemic inflammation X Ji, Z Pan, C Li, T Kang, LKC De La Cruz, L Yang, Z Yuan, B Ke, B Wang Journal of Medicinal Chemistry 62 (6), 3163-3168, 2019 | 62 | 2019 |
Click, release, and fluoresce: a chemical strategy for a cascade prodrug system for codelivery of carbon monoxide, a drug payload, and a fluorescent reporter LKC De La Cruz, SL Benoit, Z Pan, B Yu, RJ Maier, X Ji, B Wang Organic letters 20 (4), 897-900, 2018 | 54 | 2018 |
Organic CO prodrugs activated by endogenous ROS Z Pan, J Zhang, K Ji, V Chittavong, X Ji, B Wang Organic letters 20 (1), 8-11, 2018 | 54 | 2018 |
Making smart drugs smarter: The importance of linker chemistry in targeted drug delivery X Yang, Z Pan, MR Choudhury, Z Yuan, A Anifowose, B Yu, W Wang, ... Medicinal research reviews 40 (6), 2682-2713, 2020 | 48 | 2020 |
New coumarin derivatives: Design, synthesis and use as inhibitors of hMAO X He, YY Chen, JB Shi, WJ Tang, ZX Pan, ZQ Dong, BA Song, J Li, XH Liu Bioorganic & Medicinal Chemistry 22 (14), 3732-3738, 2014 | 47 | 2014 |
Organic carbon monoxide prodrug, BW-CO-111, in protection against chemically-induced gastric mucosal damage D Bakalarz, M Surmiak, X Yang, D Wójcik, E Korbut, Z Śliwowski, G Ginter, ... Acta Pharmaceutica Sinica B 11 (2), 456-475, 2021 | 44 | 2021 |
Click and release: a high-content bioorthogonal prodrug with multiple outputs X Ji, RE Aghoghovbia, LKC De La Cruz, Z Pan, X Yang, B Yu, B Wang Organic letters 21 (10), 3649-3652, 2019 | 34 | 2019 |
New 2H-chromene-3-carboxamide derivatives: Design, synthesis and use as inhibitors of hMAO ZX Pan, X He, YY Chen, WJ Tang, JB Shi, YL Tang, BA Song, J Li, XH Liu European journal of medicinal chemistry 80, 278-284, 2014 | 33 | 2014 |
Towards “CO in a pill”: Pharmacokinetic studies of carbon monoxide prodrugs in mice M Wang, X Yang, Z Pan, Y Wang, LK De La Cruz, B Wang, C Tan Journal of Controlled Release 327, 174-185, 2020 | 31 | 2020 |
Discovery of a highly efficient nitroaryl group for detection of nitroreductase and imaging of hypoxic tumor cells S Wang, X Wu, Y Zhang, D Zhang, B Xie, Z Pan, K Ouyang, T Peng Organic & Biomolecular Chemistry 19 (15), 3469-3478, 2021 | 16 | 2021 |
Upregulation of p53 through induction of MDM2 degradation: amino acid prodrugs of anthraquinone analogs A Anifowose, Z Yuan, X Yang, Z Pan, Y Zheng, Z Zhang, B Wang Bioorganic & medicinal chemistry letters 30 (2), 126786, 2020 | 13 | 2020 |
Carbon-monoxide-releasing molecules and therapeutic applications thereof B Wang, X Ji, PAN Zhixiang US Patent 11,420,994, 2022 | 2 | 2022 |
A Stable Precursor for Bioorthogonally Removable 3-Isocyanopropyloxycarbonyl (ICPrc) Protecting Groups J Tu, M Xu, RM Franzini Synlett 31 (17), 1701-1706, 2020 | 2 | 2020 |