SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids J Jansen, KC Reimer, JS Nagai, FS Varghese, GJ Overheul, M de Beer, ... Cell stem cell 29 (2), 217-231. e8, 2022 | 185 | 2022 |
A pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activity CJ Macuamule, ET Tjhin, CE Jana, L Barnard, L Koekemoer, M De Villiers, ... Antimicrobial agents and chemotherapy 59 (6), 3666-3668, 2015 | 52 | 2015 |
COVID moonshot: open science discovery of SARS-CoV-2 main protease inhibitors by combining crowdsourcing, high-throughput experiments, computational simulations, and machine … H Achdout, A Aimon, E Bar-David, GM Morris BioRxiv, 2020 | 50 | 2020 |
Novel and improved crystal structures of H. influenzae, E. coli and P. aeruginosa penicillin-binding protein 3 (PBP3) and N. gonorrhoeae PBP2: toward a better understanding of … D Bellini, L Koekemoer, H Newman, CG Dowson Journal of molecular biology 431 (18), 3501-3519, 2019 | 46 | 2019 |
Variation in pantothenate kinase type determines the pantothenamide mode of action and impacts on coenzyme A salvage biosynthesis M de Villiers, L Barnard, L Koekemoer, JL Snoep, E Strauss The FEBS journal 281 (20), 4731-4753, 2014 | 46 | 2014 |
Open Science Discovery of Potent Non-Covalent SARS-CoV-2 Main Protease Inhibitors COVID Moonshot Consortium, H Achdout, A Aimon, DS Alonzi, R Arbon, ... BioRxiv, 2020.10. 29.339317, 2020 | 39 | 2020 |
Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors ML Boby, D Fearon, M Ferla, M Filep, L Koekemoer, MC Robinson, ... Science 382 (6671), eabo7201, 2023 | 37 | 2023 |
The low-cost Shifter microscope stage transforms the speed and robustness of protein crystal harvesting ND Wright, P Collins, L Koekemoer, T Krojer, R Talon, E Nelson, M Ye, ... Acta Crystallographica Section D: Structural Biology 77 (1), 62-74, 2021 | 34 | 2021 |
Spiropyrimidinetrione DNA gyrase inhibitors with potent and selective antituberculosis activity P Govender, R Muller, K Singh, V Reddy, CJ Eyermann, S Fienberg, ... Journal of medicinal chemistry 65 (9), 6903-6925, 2022 | 21 | 2022 |
3‐Fluoroaspartate and Pyruvoyl‐Dependant Aspartate Decarboxylase: Exploiting the Unique Characteristics of Fluorine To Probe Reactivity and Binding J de Villiers, L Koekemoer, E Strauss Chemistry–A European Journal 16 (33), 10030-10041, 2010 | 18 | 2010 |
An in-solution snapshot of SARS-COV-2 main protease maturation process and inhibition GD Noske, Y Song, RS Fernandes, R Chalk, H Elmassoudi, L Koekemoer, ... Nature Communications 14 (1), 1545, 2023 | 10 | 2023 |
The coenzyme A level modulator hopantenate (HoPan) inhibits phosphopantotenoylcysteine synthetase activity KJ Mostert, N Sharma, M Van Der Zwaag, R Staats, L Koekemoer, ... ACS chemical biology 16 (11), 2401-2414, 2021 | 9 | 2021 |
Expanding the Repertoire of Low‐Molecular‐Weight Pentafluorosulfanyl‐Substituted Scaffolds A Jose, D Guest, R LeGay, GJ Tizzard, SJ Coles, M Derveni, E Wright, ... ChemMedChem 17 (7), e202100641, 2022 | 7 | 2022 |
Analysis of the diverse antigenic landscape of the malaria invasion protein RH5 identifies a potent vaccine-induced human public antibody clonotype JR Barrett, D Pipini, ND Wright, AJR Cooper, G Gorini, D Quinkert, ... bioRxiv, 2023.10. 04.560576, 2023 | 3 | 2023 |
Multifaceted Target Specificity Analysis as a Tool in Antimicrobial Drug Development: Type III Pantothenate Kinases as a Case Study SE Brigg, L Koekemoer, LA Brand, E Strauss ChemMedChem 18 (7), e202200630, 2023 | 2 | 2023 |
High-throughput crystallography for rapid fragment growth from crude arrays by low-cost robotics H Grosjean, A Aimon, S Hassell-Hart, W Thompson, L Koekemoer, ... | 1 | 2023 |
Studies towards the selective inhibition of β-alanine pathways in Mycobacterium tuberculosis L Koekemoer Stellenbosch: University of Stellenbosch, 2006 | 1 | 2006 |
Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype JR Barrett, D Pipini, ND Wright, AJR Cooper, G Gorini, D Quinkert, ... Cell, 2024 | | 2024 |
High-throughput crystallographic fragment screening of Zika virus NS3 Helicase AS Godoy, NCMR Mesquita, GD Noske, VO Gawriljuk, RM Lithgo, ... bioRxiv, 2024 | | 2024 |
Crystallization of Zika virus NS2B-NS3 protease P Marples, D Fearon, L Koekemoer | | 2024 |