Peripheral protein quality control removes unfolded CFTR from the plasma membrane T Okiyoneda, H Barrière, M Bagdány, WM Rabeh, K Du, J Höhfeld, ... Science 329 (5993), 805-810, 2010 | 482 | 2010 |
Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function WM Rabeh, F Bossard, H Xu, T Okiyoneda, M Bagdany, CM Mulvihill, ... Cell 148 (1), 150-163, 2012 | 334 | 2012 |
In situ proteolysis for protein crystallization and structure determination A Dong, X Xu, AM Edwards Nature methods 4 (12), 1019-1021, 2007 | 290 | 2007 |
Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD+ W Tempel, WM Rabeh, KL Bogan, P Belenky, M Wojcik, HF Seidle, ... PLoS biology 5 (10), e263, 2007 | 176 | 2007 |
Small heat shock proteins target mutant cystic fibrosis transmembrane conductance regulator for degradation via a small ubiquitin-like modifier–dependent pathway A Ahner, X Gong, BZ Schmidt, KW Peters, WM Rabeh, PH Thibodeau, ... Molecular biology of the cell 24 (2), 74-84, 2013 | 114 | 2013 |
Structure and mechanism of O-acetylserine sulfhydrylase WM Rabeh, PF Cook Journal of Biological Chemistry 279 (26), 26803-26806, 2004 | 110 | 2004 |
Crystal structures of human pantothenate kinases: insights into allosteric regulation and mutations linked to a neurodegeneration disorder BS Hong, G Senisterra, WM Rabeh, M Vedadi, R Leonardi, YM Zhang, ... Journal of Biological Chemistry 282 (38), 27984-27993, 2007 | 96 | 2007 |
Catalytic dyad residues His41 and Cys145 impact the catalytic activity and overall conformational fold of the main SARS-CoV-2 protease 3-chymotrypsin-like protease JC Ferreira, S Fadl, AJ Villanueva, WM Rabeh Frontiers in chemistry 9, 692168, 2021 | 89 | 2021 |
Structure, mechanism, and conformational dynamics of O-acetylserine sulfhydrylase from Salmonella typhimurium: comparison of A and B isozymes A Chattopadhyay, M Meier, S Ivaninskii, P Burkhard, F Speroni, ... Biochemistry 46 (28), 8315-8330, 2007 | 83 | 2007 |
Regulation and cytoprotective role of hexokinase III E Wyatt, R Wu, W Rabeh, HW Park, M Ghanefar, H Ardehali PloS one 5 (11), e13823, 2010 | 78 | 2010 |
The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation MH Nawaz, JC Ferreira, L Nedyalkova, H Zhu, C Carrasco-López, ... Bioscience reports 38 (1), BSR20171666, 2018 | 67 | 2018 |
Hexokinase II–derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells AD Woldetsadik, MC Vogel, WM Rabeh, M Magzoub The FASEB Journal 31 (5), 2168, 2017 | 65 | 2017 |
Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect J Colas, G Faure, E Saussereau, S Trudel, WM Rabeh, S Bitam, ... Human molecular genetics 21 (3), 623-634, 2012 | 53 | 2012 |
Biochemical and biophysical characterization of the main protease, 3-chymotrypsin-like protease (3CLpro) from the novel coronavirus SARS-CoV 2 JC Ferreira, WM Rabeh Scientific reports 10 (1), 22200, 2020 | 41 | 2020 |
Crystallographic education in the 21st century S Gražulis, AA Sarjeant, P Moeck, J Stone-Sundberg, TJ Snyder, ... Journal of Applied Crystallography 48 (6), 1964-1975, 2015 | 39 | 2015 |
Beetle luciferases with naturally red-and blue-shifted emission C Carrasco-López, JC Ferreira, NM Lui, S Schramm, R Berraud-Pache, ... Life science alliance 1 (4), 2018 | 29 | 2018 |
Mechanism of the addition half of the O-acetylserine sulfhydrylase-A reaction WM Rabeh, SS Alguindigue, PF Cook Biochemistry 44 (14), 5541-5550, 2005 | 27 | 2005 |
Key dimer interface residues impact the catalytic activity of 3CLpro, the main protease of SARS-CoV-2 JC Ferreira, S Fadl, WM Rabeh Journal of Biological Chemistry 298 (6), 2022 | 25 | 2022 |
The elusive crystal structure of the neuraminidase inhibitor Tamiflu (oseltamivir phosphate): molecular details of action P Naumov, N Yasuda, WM Rabeh, J Bernstein Chemical Communications 49 (19), 1948-1950, 2013 | 20 | 2013 |
Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS‐CoV‐2 protease 3CLpro JC Ferreira, S Fadl, M Ilter, H Pekel, R Rezgui, O Sensoy, WM Rabeh The FASEB Journal 35 (8), 2021 | 15 | 2021 |