Increased oxidative stress precedes the onset of high-fat diet–induced insulin resistance and obesity N Matsuzawa-Nagata, T Takamura, H Ando, S Nakamura, S Kurita, ... Metabolism 57 (8), 1071-1077, 2008 | 692 | 2008 |
A liver-derived secretory protein, selenoprotein P, causes insulin resistance H Misu, T Takamura, H Takayama, H Hayashi, N Matsuzawa-Nagata, ... Cell metabolism 12 (5), 483-495, 2010 | 619 | 2010 |
Lipid‐induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet N Matsuzawa, T Takamura, S Kurita, H Misu, T Ota, H Ando, M Yokoyama, ... Hepatology 46 (5), 1392-1403, 2007 | 611 | 2007 |
Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria S Nakamura, T Takamura, N Matsuzawa-Nagata, H Takayama, H Misu, ... Journal of Biological Chemistry 284 (22), 14809-14818, 2009 | 503 | 2009 |
SGLT2 inhibition by empagliflozin promotes fat utilization and browning and attenuates inflammation and insulin resistance by polarizing M2 macrophages in diet-induced obese mice L Xu, N Nagata, M Nagashimada, F Zhuge, Y Ni, G Chen, E Mayoux, ... EBioMedicine 20, 137-149, 2017 | 433 | 2017 |
Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis T Ota, T Takamura, S Kurita, N Matsuzawa, Y Kita, M Uno, H Akahori, ... Gastroenterology 132 (1), 282-293, 2007 | 285 | 2007 |
Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E Y Ni, M Nagashimada, F Zhuge, L Zhan, N Nagata, A Tsutsui, ... Scientific reports 5 (1), 17192, 2015 | 252 | 2015 |
Regulation of gut microbiota and metabolic endotoxemia with dietary factors N Fuke, N Nagata, H Suganuma, T Ota Nutrients 11 (10), 2277, 2019 | 241 | 2019 |
DPP-4 inhibition by linagliptin attenuates obesity-related inflammation and insulin resistance by regulating M1/M2 macrophage polarization F Zhuge, Y Ni, M Nagashimada, N Nagata, L Xu, N Mukaida, S Kaneko, ... Diabetes 65 (10), 2966-2979, 2016 | 198 | 2016 |
Metformin prevents and reverses inflammation in a non-diabetic mouse model of nonalcoholic steatohepatitis Y Kita, T Takamura, H Misu, T Ota, S Kurita, Y Takeshita, M Uno, ... Public Library of Science 7 (9), e43056, 2012 | 173 | 2012 |
Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells M Nomura, T Takahashi, N Nagata, K Tsutsumi, S Kobayashi, T Akiba, ... Biological and Pharmaceutical Bulletin 31 (7), 1403-1409, 2008 | 162 | 2008 |
Clock gene expression in peripheral leucocytes of patients with type 2 diabetes H Ando, T Takamura, N Matsuzawa-Nagata, KR Shima, T Eto, H Misu, ... Diabetologia 52, 329-335, 2009 | 159 | 2009 |
LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance F Lan, H Misu, K Chikamoto, H Takayama, A Kikuchi, K Mohri, N Takata, ... Diabetes 63 (5), 1649-1664, 2014 | 158 | 2014 |
Glucoraphanin ameliorates obesity and insulin resistance through adipose tissue browning and reduction of metabolic endotoxemia in mice N Nagata, L Xu, S Kohno, Y Ushida, Y Aoki, R Umeda, N Fuke, F Zhuge, ... Diabetes 66 (5), 1222-1236, 2017 | 153 | 2017 |
Soluble epoxide hydrolase deficiency or inhibition attenuates diet-induced endoplasmic reticulum stress in liver and adipose tissue A Bettaieb, N Nagata, D AbouBechara, S Chahed, C Morisseau, ... Journal of Biological Chemistry 288 (20), 14189-14199, 2013 | 143 | 2013 |
Protecting cisplatin-induced nephrotoxicity with cimetidine does not affect antitumor activity H Katsuda, M Yamashita, H Katsura, J Yu, Y Waki, N Nagata, Y Sai, ... Biological and Pharmaceutical Bulletin 33 (11), 1867-1871, 2010 | 133 | 2010 |
Obesity upregulates genes involved in oxidative phosphorylation in livers of diabetic patients T Takamura, H Misu, N Matsuzawa‐Nagata, M Sakurai, T Ota, A Shimizu, ... Obesity 16 (12), 2601-2609, 2008 | 127 | 2008 |
Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes H Misu, T Takamura, N Matsuzawa, A Shimizu, T Ota, M Sakurai, H Ando, ... Diabetologia 50 (2), 268-277, 2007 | 124 | 2007 |
Prevention and reversal of lipotoxicity-induced hepatic insulin resistance and steatohepatitis in mice by an antioxidant carotenoid, β-cryptoxanthin Y Ni, M Nagashimada, L Zhan, N Nagata, M Kobori, M Sugiura, K Ogawa, ... Endocrinology 156 (3), 987-999, 2015 | 113 | 2015 |
Central insulin action activates Kupffer cells by suppressing hepatic vagal activation via the nicotinic alpha 7 acetylcholine receptor K Kimura, M Tanida, N Nagata, Y Inaba, H Watanabe, M Nagashimada, ... Cell Reports 14 (10), 2362-2374, 2016 | 100 | 2016 |