The cytosolic sensor cGAS detects Mycobacterium tuberculosis DNA to induce type I interferons and activate autophagy RO Watson*, SL Bell*, DA MacDuff, JM Kimmey, EJ Diner, J Olivas, ... Cell host & microbe 17 (6), 811-819, 2015 | 619 | 2015 |
A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1 B Zhao, F Du, P Xu, C Shu, B Sankaran, SL Bell, M Liu, Y Lei, X Gao, X Fu, ... Nature 569 (7758), 718-722, 2019 | 295 | 2019 |
Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum AN Chiang, JC Valderramos, R Balachandran, RJ Chovatiya, BP Mead, ... Bioorganic & medicinal chemistry 17 (4), 1527-1533, 2009 | 169 | 2009 |
Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis CG Weindel, EL Martinez, X Zhao, CJ Mabry, SL Bell, KJ Vail, ... Cell 185 (17), 3214-3231. e23, 2022 | 160 | 2022 |
LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis CG Weindel*, SL Bell*, KJ Vail, KO West, KL Patrick, RO Watson eLife 9, e51071, 2020 | 103 | 2020 |
An Mtb-human protein-protein interaction map identifies a switch between host antiviral and antibacterial responses BH Penn, Z Netter, JR Johnson, J Von Dollen, GM Jang, T Johnson, ... Molecular cell 71 (4), 637-648. e5, 2018 | 98 | 2018 |
Exploring the “multiple-hit hypothesis” of neurodegenerative disease: bacterial infection comes up to bat KL Patrick, SL Bell, CG Weindel, RO Watson Frontiers in cellular and infection microbiology 9, 138, 2019 | 90 | 2019 |
Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice Y Lei, CG Martinez, S Torres-Odio, SL Bell, CE Birdwell, JD Bryant, ... Science Advances 7 (22), eabe7548, 2021 | 70 | 2021 |
Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages SL Bell, KL Lopez, JS Cox, KL Patrick, RO Watson mBio 12 (4), e01871-20, 2021 | 54 | 2021 |
TRIM14 Is a Key Regulator of the Type I IFN Response during Mycobacterium tuberculosis Infection CT Hoffpauir, SL Bell, KO West, T Jing, AR Wagner, S Torres-Odio, ... The Journal of Immunology 205 (1), 153-167, 2020 | 49 | 2020 |
Expression of a malarial Hsp70 improves defects in chaperone-dependent activities in ssa1 mutant yeast SL Bell, AN Chiang, JL Brodsky PLoS One 6 (5), e20047, 2011 | 31 | 2011 |
The BiP molecular chaperone plays multiple roles during the biogenesis of torsinA, an AAA+ ATPase associated with the neurological disease early-onset torsion dystonia LF Zacchi, HC Wu, SL Bell, L Millen, AW Paton, JC Paton, PJ Thomas, ... Journal of Biological Chemistry 289 (18), 12727-12747, 2014 | 27 | 2014 |
For better or worse: cytosolic DNA sensing during intracellular bacterial infection induces potent innate immune responses KL Patrick*, SL Bell*, RO Watson Journal of molecular biology 428 (17), 3372-3386, 2016 | 26 | 2016 |
Quantitative yeast genetic interaction profiling of bacterial effector proteins uncovers a role for the human retromer in Salmonella infection KL Patrick, JA Wojcechowskyj, SL Bell, MN Riba, T Jing, S Talmage, P Xu, ... Cell systems 7 (3), 323-338. e6, 2018 | 21 | 2018 |
The opportunistic intracellular bacterial pathogen Rhodococcus equi elicits type I interferon by engaging cytosolic DNA sensing in macrophages KJ Vail, BP da Silveira, SL Bell, ND Cohen, AI Bordin, KL Patrick, ... PLoS pathogens 17 (9), e1009888, 2021 | 10 | 2021 |
Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens HM Morrison, J Craft, R Rivera-Lugo, JR Johnson, GR Golovkine, SL Bell, ... PLoS pathogens 19 (6), e1011088, 2023 | 6 | 2023 |
Interactions between fungal hyaluronic acid and host CD44 promote internalization by recruiting host autophagy proteins to forming phagosomes S Ding, J Yang, X Feng, A Pandey, R Barhoumi, D Zhang, SL Bell, Y Liu, ... Iscience 24 (3), 2021 | 6 | 2021 |
Mitochondrial dysfunction promotes alternative gasdermin D-mediated inflammatory cell death and susceptibility to infection CG Weindel, X Zhao, E Martinez, SL Bell, KJ Vail, AK Coleman, ... bioRxiv, 2021.11. 18.469014, 2021 | 5 | 2021 |
LRRK2 regulates innate immune responses and neuroinflammation during Mycobacterium tuberculosis infection CG Weindel*, SL Bell*, TE Huntington, KJ Vail, R Srinivasan, KL Patrick, ... bioRxiv, 699066, 2019 | 5 | 2019 |
Type I interferon potentiates metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice Y Lei, CG Martinez, S Torres-Odio, SL Bell, CE Birdwell, JD Bryant, ... bioRxiv, 2020.09. 22.308171, 2020 | 2 | 2020 |