Antimalarial drug discovery: efficacy models for compound screening DA Fidock, PJ Rosenthal, SL Croft, R Brun, S Nwaka Nature Reviews Drug discovery 3 (6), 509-520, 2004 | 1230 | 2004 |
Innovative lead discovery strategies for tropical diseases S Nwaka, A Hudson Nature Reviews Drug Discovery 5 (11), 941-955, 2006 | 660 | 2006 |
Genomic-scale prioritization of drug targets: the TDR Targets database F Agüero, B Al-Lazikani, M Aslett, M Berriman, FS Buckner, RK Campbell, ... Nature reviews Drug discovery 7 (11), 900-907, 2008 | 362 | 2008 |
Virtual drug discovery and development for neglected diseases through public–private partnerships S Nwaka, RG Ridley Nature Reviews Drug Discovery 2 (11), 919-928, 2003 | 357 | 2003 |
Molecular biology of trehalose and the trehalases in the yeast Saccharomyces cerevisiae S Nwaka, H Holzer Progress in nucleic acid research and molecular biology (K. Moldave Ed.) 58 …, 1997 | 243 | 1997 |
Advancing drug innovation for neglected diseases—criteria for lead progression S Nwaka, B Ramirez, R Brun, L Maes, F Douglas, R Ridley PLoS neglected tropical diseases 3 (8), e440, 2009 | 200 | 2009 |
Identification of Attractive Drug Targets in Neglected-Disease Pathogens Using an In Silico Approach GJ Crowther, D Shanmugam, SJ Carmona, MA Doyle, C Hertz-Fowler, ... PLoS neglected tropical diseases 4 (8), e804, 2010 | 192 | 2010 |
Schistosomes: challenges in compound screening B Ramirez, Q Bickle, F Yousif, F Fakorede, MA Mouries, S Nwaka Expert opinion on drug discovery 2 (sup1), S53-S61, 2007 | 168 | 2007 |
Activity of human Δ5 and Δ6 desaturases on multiple n-3 and n-6 polyunsaturated fatty acids RJ de Antueno, LC Knickle, H Smith, ML Elliot, SJ Allen, S Nwaka, ... FEBS letters 509 (1), 77-80, 2001 | 155 | 2001 |
Induction of neutral trehalase Nth1 by heat and osmotic stress is controlled by STRE elements and Msn2/Msn4 transcription factors: variations of PKA effect during stress and growth H Zähringer, JM Thevelein, S Nwaka Molecular microbiology 35 (2), 397-406, 2000 | 152 | 2000 |
Expression and Function of the Trehalase Genes NTH1 and YBR0106 in Saccharomyces cerevisiae (∗) S Nwaka, M Kopp, H Holzer Journal of Biological Chemistry 270 (17), 10193-10198, 1995 | 145 | 1995 |
Deletion of the ATH1 gene in Saccharomyces cerevisiae prevents growth on trehalose S Nwaka, B Mechler, H Holzer FEBS letters 386 (2-3), 235-238, 1996 | 133 | 1996 |
Phenotypic features of trehalase mutants in Saccharomyces cerevisiae S Nwaka, B Mechler, M Destruelle, H Holzer Febs Letters 360 (3), 286-290, 1995 | 130 | 1995 |
Neutral trehalase Nth1p of Saccharomyces cerevisiae encoded by the NTH1 gene is a multiple stress responsive protein H Zähringer, M Burgert, H Holzer, S Nwaka FEBS letters 412 (3), 615-620, 1997 | 113 | 1997 |
Opposite roles of trehalase activity in heat-shock recovery and heat-shock survival in Saccharomyces cerevisiae S WERA, EDE SCHRIJVER, I GEYSKENS, S NWAKA, JM THEVELEIN Biochemical Journal 343 (3), 621-626, 1999 | 98 | 1999 |
Developing ANDI: a novel approach to health product R&D in Africa S Nwaka, TB Ilunga, JS Da Silva, E Rial Verde, D Hackley, R De Vré, ... PLoS Medicine 7 (6), e1000293, 2010 | 85 | 2010 |
Is thermotolerance of yeast dependent on trehalose accumulation? S Nwaka, M Kopp, M Burgert, I Deuchler, I Kienle, H Holzer FEBS letters 344 (2-3), 225-228, 1994 | 76 | 1994 |
Analysis of pan-African Centres of excellence in health innovation highlights opportunities and challenges for local innovation and financing in the continent S Nwaka, A Ochem, D Besson, B Ramirez, F Fakorede, S Botros, ... BMC international health and human rights 12, 1-15, 2012 | 67 | 2012 |
Mission possible AL Hopkins, MJ Witty, S Nwaka Nature 449 (7159), 166-169, 2007 | 66 | 2007 |
Drug discovery and beyond: the role of public-private partnerships in improving access to new malaria medicines S Nwaka Transactions of the Royal Society of Tropical Medicine and Hygiene 99 …, 2005 | 64 | 2005 |