| Evolvability and hierarchy in rewired bacterial gene networks M Isalan, C Lemerle, K Michalodimitrakis, C Horn, P Beltrao, E Raineri, ... Nature 452 (7189), 840-845, 2008 | 372 | 2008 |
| A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter M Isalan, A Klug, Y Choo Nature biotechnology 19 (7), 656-660, 2001 | 275 | 2001 |
| Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity S Tan, D Guschin, A Davalos, YL Lee, AW Snowden, Y Jouvenot, ... Proceedings of the National Academy of Sciences 100 (21), 11997-12002, 2003 | 268 | 2003 |
| Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice M Garriga-Canut, C Agustín-Pavón, F Herrmann, A Sánchez, M Dierssen, ... Proceedings of the National Academy of Sciences 109 (45), E3136-E3145, 2012 | 241 | 2012 |
| Synergy between adjacent zinc fingers in sequence-specific DNA recognition M Isalan, Y Choo, A Klug Proceedings of the National Academy of Sciences 94 (11), 5617-5621, 1997 | 230 | 1997 |
| Comprehensive DNA recognition through concerted interactions from adjacent zinc fingers M Isalan, A Klug, Y Choo Biochemistry 37 (35), 12026-12033, 1998 | 174 | 1998 |
| Repression of the HIV-1 5′ LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors L Reynolds, C Ullman, M Moore, M Isalan, MJ West, P Clapham, A Klug, ... Proceedings of the National Academy of Sciences 100 (4), 1615-1620, 2003 | 169 | 2003 |
| Gene therapy advances: a meta-analysis of AAV usage in clinical settings HKE Au, M Isalan, M Mielcarek Frontiers in medicine 8, 809118, 2022 | 160 | 2022 |
| Inhibition of herpes simplex virus 1 gene expression by designer zinc-finger transcription factors M Papworth, M Moore, M Isalan, M Minczuk, Y Choo, A Klug Proceedings of the National Academy of Sciences 100 (4), 1621-1626, 2003 | 158 | 2003 |
| A unified design space of synthetic stripe-forming networks Y Schaerli, A Munteanu, M Gili, J Cotterell, J Sharpe, M Isalan Nature communications 5 (1), 4905, 2014 | 154 | 2014 |
| Engineering Gene Networks to Emulate Drosophila Embryonic Pattern Formation M Isalan, C Lemerle, L Serrano PLoS biology 3 (3), e64, 2005 | 145 | 2005 |
| Advances in zinc finger engineering Y Choo, M Isalan Current Opinion in Structural Biology 10 (4), 411-416, 2000 | 133 | 2000 |
| Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein F Guidez, L Howell, M Isalan, M Cebrat, RM Alani, S Ivins, I Hormaeche, ... Molecular and cellular biology 25 (13), 5552-5566, 2005 | 115 | 2005 |
| Nucleic acid binding proteins Y Choo, A Klug, M Isalan US Patent 6,746,838, 2004 | 110 | 2004 |
| Nucleic acid binding proteins Y Choo, A Klug, M Isalan US Patent 6,866,997, 2005 | 102 | 2005 |
| Combining a toggle switch and a repressilator within the AC-DC circuit generates distinct dynamical behaviors R Perez-Carrasco, CP Barnes, Y Schaerli, M Isalan, J Briscoe, KM Page Cell systems 6 (4), 521-530. e3, 2018 | 89 | 2018 |
| Zinc-finger nucleases: how to play two good hands M Isalan Nature methods 9 (1), 32-34, 2012 | 89 | 2012 |
| A comprehensive network atlas reveals that Turing patterns are common but not robust NS Scholes, D Schnoerr, M Isalan, MPH Stumpf Cell systems 9 (3), 243-257. e4, 2019 | 82 | 2019 |
| Selection of zinc fingers that bind single-stranded telomeric DNA in the G-quadruplex conformation M Isalan, SD Patel, S Balasubramanian, Y Choo Biochemistry 40 (3), 830-836, 2001 | 79 | 2001 |
| Computer design of obligate heterodimer meganucleases allows efficient cutting of custom DNA sequences E Fajardo-Sanchez, F Stricher, F Paˆques, M Isalan, L Serrano Nucleic acids research 36 (7), 2163-2173, 2008 | 75 | 2008 |
Michal MielcarekImperial College london在 imperial.ac.uk 的电子邮件经过验证
