Activation of innate immunity is required for efficient nuclear reprogramming J Lee, N Sayed, A Hunter, KF Au, WH Wong, ES Mocarski, RR Pera, ... Cell 151 (3), 547-558, 2012 | 380 | 2012 |
High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells A Sharma, PW Burridge, WL McKeithan, R Serrano, P Shukla, N Sayed, ... Science translational medicine 9 (377), eaaf2584, 2017 | 359 | 2017 |
Translation of human-induced pluripotent stem cells: from clinical trial in a dish to precision medicine N Sayed, C Liu, JC Wu Journal of the American College of Cardiology 67 (18), 2161-2176, 2016 | 296 | 2016 |
NO and CO differentially activate soluble guanylyl cyclase via a heme pivot‐bend mechanism X Ma, N Sayed, A Beuve, F Van Den Akker The EMBO journal 26 (2), 578-588, 2007 | 274 | 2007 |
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging N Sayed, Y Huang, K Nguyen, Z Krejciova-Rajaniemi, AP Grawe, T Gao, ... Nature aging 1 (7), 598-615, 2021 | 271 | 2021 |
Modeling human diseases with induced pluripotent stem cells: from 2D to 3D and beyond C Liu, A Oikonomopoulos, N Sayed, JC Wu Development 145 (5), dev156166, 2018 | 270 | 2018 |
Desensitization of soluble guanylyl cyclase, the NO receptor, by S-nitrosylation N Sayed, P Baskaran, X Ma, F Van Den Akker, A Beuve Proceedings of the National Academy of Sciences 104 (30), 12312-12317, 2007 | 250 | 2007 |
Transdifferentiation of human fibroblasts to endothelial cells: role of innate immunity N Sayed, WT Wong, F Ospino, S Meng, J Lee, A Jha, P Dexheimer, ... Circulation 131 (3), 300-309, 2015 | 185 | 2015 |
Transcriptome profiling of patient-specific human iPSC-cardiomyocytes predicts individual drug safety and efficacy responses in vitro E Matsa, PW Burridge, KH Yu, JH Ahrens, V Termglinchan, H Wu, C Liu, ... Cell stem cell 19 (3), 311-325, 2016 | 173 | 2016 |
Human-induced pluripotent stem cell model of trastuzumab-induced cardiac dysfunction in patients with breast cancer T Kitani, SG Ong, CK Lam, JW Rhee, JZ Zhang, A Oikonomopoulos, N Ma, ... Circulation 139 (21), 2451-2465, 2019 | 162 | 2019 |
Large-scale single-cell RNA-seq reveals molecular signatures of heterogeneous populations of human induced pluripotent stem cell-derived endothelial cells DT Paik, L Tian, J Lee, N Sayed, IY Chen, S Rhee, JW Rhee, Y Kim, ... Circulation research 123 (4), 443-450, 2018 | 139 | 2018 |
Nitroglycerin-induced S-nitrosylation and desensitization of soluble guanylyl cyclase contribute to nitrate tolerance N Sayed, DD Kim, X Fioramonti, T Iwahashi, WN Durán, A Beuve Circulation research 103 (6), 606-614, 2008 | 138 | 2008 |
Determining the pathogenicity of a genomic variant of uncertain significance using CRISPR/Cas9 and human-induced pluripotent stem cells N Ma, JZ Zhang, I Itzhaki, SL Zhang, H Chen, F Haddad, T Kitani, ... Circulation 138 (23), 2666-2681, 2018 | 130 | 2018 |
A human iPSC double-reporter system enables purification of cardiac lineage subpopulations with distinct function and drug response profiles JZ Zhang, V Termglinchan, NY Shao, I Itzhaki, C Liu, N Ma, L Tian, ... Cell Stem Cell 24 (5), 802-811. e5, 2019 | 120 | 2019 |
PAS-mediated dimerization of soluble guanylyl cyclase revealed by signal transduction histidine kinase domain crystal structure X Ma, N Sayed, P Baskaran, A Beuve, F Van Den Akker Journal of Biological Chemistry 283 (2), 1167-1178, 2008 | 118 | 2008 |
An in Vivo miRNA Delivery System for Restoring Infarcted Myocardium H Yang, X Qin, H Wang, X Zhao, Y Liu, HT Wo, C Liu, M Nishiga, H Chen, ... ACS nano 13 (9), 9880-9894, 2019 | 113 | 2019 |
Vascular aging: implications for cardiovascular disease and therapy YT Ghebre, E Yakubov, WT Wong, P Krishnamurthy, N Sayed, AG Sikora, ... Translational medicine (Sunnyvale, Calif.) 6 (4), 2016 | 91 | 2016 |
Big bottlenecks in cardiovascular tissue engineering NF Huang, V Serpooshan, VB Morris, N Sayed, G Pardon, OJ Abilez, ... Communications biology 1 (1), 199, 2018 | 86 | 2018 |
Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes PP Shah, W Lv, JH Rhoades, A Poleshko, D Abbey, MA Caporizzo, ... Cell Stem Cell 28 (5), 938-954. e9, 2021 | 78 | 2021 |
Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs MT Zhao, H Chen, Q Liu, NY Shao, N Sayed, HT Wo, JZ Zhang, SG Ong, ... Proceedings of the National Academy of Sciences 114 (52), E11111-E11120, 2017 | 76 | 2017 |