Nuclear and neuropil aggregates in Huntington’s disease: relationship to neuropathology CA Gutekunst, SH Li, H Yi, JS Mulroy, S Kuemmerle, R Jones, D Rye, ... Journal of Neuroscience 19 (7), 2522-2534, 1999 | 1084 | 1999 |
A huntingtin-associated protein enriched in brain with implications for pathology XJ Li, SH Li, AH Sharp, FC Nucifora, G Schilling, A Lanahan, P Worley, ... Nature 378 (6555), 398-402, 1995 | 764 | 1995 |
Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice M Gray, DI Shirasaki, C Cepeda, VM André, B Wilburn, XH Lu, J Tao, ... Journal of Neuroscience 28 (24), 6182-6195, 2008 | 736 | 2008 |
Huntingtin–protein interactions and the pathogenesis of Huntington's disease SH Li, XJ Li TRENDS in Genetics 20 (3), 146-154, 2004 | 691 | 2004 |
Widespread expression of Huntington's disease gene (IT15) protein product AH Sharp, SJ Loev, G Schilling, SH Li, XJ Li, J Bao, MV Wagster, ... Neuron 14 (5), 1065-1074, 1995 | 631 | 1995 |
The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production L Pastorino, A Sun, PJ Lu, XZ Zhou, M Balastik, G Finn, G Wulf, J Lim, ... Nature 440 (7083), 528-534, 2006 | 587 | 2006 |
Towards a transgenic model of Huntington’s disease in a non-human primate SH Yang, PH Cheng, H Banta, K Piotrowska-Nitsche, JJ Yang, ... Nature 453 (7197), 921-924, 2008 | 569 | 2008 |
Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice VC Wheeler, JK White, CA Gutekunst, V Vrbanac, M Weaver, XJ Li, SH Li, ... Human molecular genetics 9 (4), 503-513, 2000 | 534 | 2000 |
Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity JY Shin, ZH Fang, ZX Yu, CE Wang, SH Li, XJ Li The Journal of cell biology 171 (6), 1001-1012, 2005 | 529 | 2005 |
Huntingtin aggregates may not predict neuronal death in Huntington's disease S Kuemmerle, CA Gutekunst, AM Klein, XJ Li, SH Li, MF Beal, SM Hersch, ... Annals of neurology 46 (6), 842-849, 1999 | 512 | 1999 |
N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking AL Orr, S Li, CE Wang, H Li, J Wang, J Rong, X Xu, PG Mastroberardino, ... Journal of Neuroscience 28 (11), 2783-2792, 2008 | 487 | 2008 |
Huntington's disease gene (IT15) is widely expressed in human and rat tissues SH Li, G Schilling, WS Young Iii, RL Margolis, OC Stine, MV Wagster, ... Neuron 11 (5), 985-993, 1993 | 457 | 1993 |
Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice H Li, SH Li, ZX Yu, P Shelbourne, XJ Li Journal of Neuroscience 21 (21), 8473-8481, 2001 | 436 | 2001 |
Interaction of Huntington disease protein with transcriptional activator Sp1 SH Li, AL Cheng, H Zhou, S Lam, M Rao, H Li, XJ Li Molecular and cellular biology 22 (5), 1277-1287, 2002 | 415 | 2002 |
CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington’s disease S Yang, R Chang, H Yang, T Zhao, Y Hong, HE Kong, X Sun, Z Qin, P Jin, ... The Journal of clinical investigation 127 (7), 2719-2724, 2017 | 398 | 2017 |
Microsatellite evolution—evidence for directionality and variation in rate between species DC Rubinsztein, W Amos, J Leggo, S Goodburn, S Jain, SH Li, ... Nature genetics 10 (3), 337-343, 1995 | 397 | 1995 |
Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms J Bradford, JY Shin, M Roberts, CE Wang, XJ Li, S Li Proceedings of the National Academy of Sciences 106 (52), 22480-22485, 2009 | 364 | 2009 |
Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity H Li, SH Li, H Johnston, PF Shelbourne, XJ Li Nature genetics 25 (4), 385-389, 2000 | 358 | 2000 |
Interaction of huntingtin-associated protein with dynactin P150Glued SH Li, CA Gutekunst, SM Hersch, XJ Li Journal of Neuroscience 18 (4), 1261-1269, 1998 | 345 | 1998 |
Lymphocyte apoptosis: mediation by increased type 3 inositol 1, 4, 5-trisphosphate receptor AA Khan, MJ Soloski, AH Sharp, G Schilling, DM Sabatini, SH Li, CA Ross, ... Science 273 (5274), 503-507, 1996 | 333 | 1996 |