| Structural basis of PROTAC cooperative recognition for selective protein degradation MS Gadd, A Testa, X Lucas, KH Chan, W Chen, DJ Lamont, M Zengerle, ... Nature chemical biology 13 (5), 514-521, 2017 | 1067 | 2017 |
| Structure-guided design and optimization of small molecules targeting the protein–protein interaction between the von Hippel–Lindau (VHL) E3 ubiquitin ligase and the hypoxia … C Galdeano, MS Gadd, P Soares, S Scaffidi, I Van Molle, I Birced, ... Journal of Medicinal Chemistry 57 (20), 8657-8663, 2014 | 436 | 2014 |
| Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition J Frost, C Galdeano, P Soares, MS Gadd, KM Grzes, L Ellis, O Epemolu, ... Nature communications 7 (1), 13312, 2016 | 218 | 2016 |
| Group-based optimization of potent and cell-active inhibitors of the von Hippel–Lindau (VHL) E3 ubiquitin ligase: structure–activity relationships leading to the chemical probe … P Soares, MS Gadd, J Frost, C Galdeano, L Ellis, O Epemolu, S Rocha, ... Journal of medicinal chemistry 61 (2), 599-618, 2018 | 155 | 2018 |
| Crystal structure of the Cul2-Rbx1-EloBC-VHL ubiquitin ligase complex TAF Cardote, MS Gadd, A Ciulli Structure 25 (6), 901-911. e3, 2017 | 141 | 2017 |
| 3-Fluoro-4-hydroxyprolines: synthesis, conformational analysis, and stereoselective recognition by the VHL E3 ubiquitin ligase for targeted protein degradation A Testa, X Lucas, GV Castro, KH Chan, JE Wright, AC Runcie, MS Gadd, ... Journal of the American Chemical Society 140 (29), 9299-9313, 2018 | 137 | 2018 |
| Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification MS Gadd, M Bhati, CM Jeffries, DB Langley, J Trewhella, JM Guss, ... Journal of Biological Chemistry 286 (50), 42971-42980, 2011 | 48 | 2011 |
| A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra-and intermolecular interactions MS Gadd, DA Jacques, I Nisevic, VJ Craig, AH Kwan, JM Guss, ... Journal of Biological Chemistry 288 (30), 21924-21935, 2013 | 38 | 2013 |
| Biochemical and biophysical characterisation of haloalkane dehalogenases DmrA and DmrB in Mycobacterium strain JS60 and their role in growth on haloalkanes HKH Fung, MS Gadd, TA Drury, S Cheung, JM Guss, NV Coleman, ... Molecular microbiology 97 (3), 439-453, 2015 | 27 | 2015 |
| Serendipitous SAD solution for DMSO-soaked SOCS2-elonginC-elonginB crystals using covalently incorporated dimethylarsenic: insights into substrate receptor conformational … MS Gadd, E Bulatov, A Ciulli PloS one 10 (6), e0131218, 2015 | 18 | 2015 |
| Selective Wee1 degradation by PROTAC degraders recruiting VHL and CRBN E3 ubiquitin ligases MC Aublette, TA Harrison, EJ Thorpe, MS Gadd Bioorganic & Medicinal Chemistry Letters 64, 128636, 2022 | 16 | 2022 |
| Solution structure of the LIM-homeodomain transcription factor complex Lhx3/Ldb1 and the effects of a pituitary mutation on key Lhx3 interactions M Bhati, C Lee, MS Gadd, CM Jeffries, A Kwan, AE Whitten, J Trewhella, ... PLoS One 7 (7), e40719, 2012 | 16 | 2012 |
| Crystallization and diffraction of an Lhx4–Isl2 complex MS Gadd, DB Langley, JM Guss, JM Matthews Acta Crystallographica Section F: Structural Biology and Crystallization …, 2009 | 8 | 2009 |
| Crystallization and diffraction of an Isl1–Ldb1 complex MS Gadd, DA Jacques, JM Guss, JM Matthews Acta Crystallographica Section F 68 (11), 1398-1401, 2012 | 4 | 2012 |
| A Structural and Biophysical Perspective of Degrader Activity Through Ternary Complex Formation MS Gadd, MC Aublette Inducing Targeted Protein Degradation: From Chemical Biology to Drug …, 2022 | 1 | 2022 |
| Investigating the LIM-binding Properties of the Islet LIM-homeodomain Proteins MS Gadd University of Sydney, 2013 | | 2013 |
