| Crystal structure of the µ-opioid receptor bound to a morphinan antagonist A Manglik, AC Kruse, TS Kobilka, FS Thian, JM Mathiesen, RK Sunahara, ... Nature 485 (7398), 321-326, 2012 | 1610 | 2012 |
| Structure-based discovery of opioid analgesics with reduced side effects A Manglik, H Lin, DK Aryal, JD McCorvy, D Dengler, G Corder, A Levit, ... Nature 537 (7619), 185-190, 2016 | 983 | 2016 |
| Activation and allosteric modulation of a muscarinic acetylcholine receptor AC Kruse, AM Ring, A Manglik, J Hu, K Hu, K Eitel, H Hübner, E Pardon, ... Nature 504 (7478), 101-106, 2013 | 972 | 2013 |
| Structural insights into µ-opioid receptor activation W Huang, A Manglik, AJ Venkatakrishnan, T Laeremans, EN Feinberg, ... Nature 524 (7565), 315-321, 2015 | 917 | 2015 |
| The dynamic process of β2-adrenergic receptor activation R Nygaard, Y Zou, RO Dror, TJ Mildorf, DH Arlow, A Manglik, AC Pan, ... Cell 152 (3), 532-542, 2013 | 896 | 2013 |
| Structure of the δ-opioid receptor bound to naltrindole S Granier, A Manglik, AC Kruse, TS Kobilka, FS Thian, WI Weis, ... Nature 485 (7398), 400-404, 2012 | 830 | 2012 |
| Structural insights into the dynamic process of β2-adrenergic receptor signaling A Manglik, TH Kim, M Masureel, C Altenbach, Z Yang, D Hilger, MT Lerch, ... Cell 161 (5), 1101-1111, 2015 | 694 | 2015 |
| Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms DE Gordon, J Hiatt, M Bouhaddou, VV Rezelj, S Ulferts, H Braberg, ... Science 370 (6521), eabe9403, 2020 | 645 | 2020 |
| Structure of the µ-opioid receptor–Gi protein complex A Koehl, H Hu, S Maeda, Y Zhang, Q Qu, JM Paggi, NR Latorraca, ... Nature 558 (7711), 547-552, 2018 | 641 | 2018 |
| Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody AM Ring, A Manglik, AC Kruse, MD Enos, WI Weis, KC Garcia, BK Kobilka Nature 502 (7472), 575-579, 2013 | 542 | 2013 |
| Crystal structure of the human σ1 receptor HR Schmidt, S Zheng, E Gurpinar, A Koehl, A Manglik, AC Kruse Nature 532 (7600), 527-530, 2016 | 484 | 2016 |
| Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide AK Shukla, A Manglik, AC Kruse, K Xiao, RI Reis, WC Tseng, DP Staus, ... Nature 497 (7447), 137-141, 2013 | 475 | 2013 |
| Yeast surface display platform for rapid discovery of conformationally selective nanobodies C McMahon, AS Baier, R Pascolutti, M Wegrecki, S Zheng, JX Ong, ... Nature structural & molecular biology 25 (3), 289-296, 2018 | 438 | 2018 |
| Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging RL Maute, SR Gordon, AT Mayer, MN McCracken, A Natarajan, NG Ring, ... Proceedings of the National Academy of Sciences 112 (47), E6506-E6514, 2015 | 389 | 2015 |
| An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike M Schoof, B Faust, RA Saunders, S Sangwan, V Rezelj, N Hoppe, ... Science 370 (6523), 1473-1479, 2020 | 385 | 2020 |
| Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation DP Staus, RT Strachan, A Manglik, B Pani, AW Kahsai, TH Kim, ... Nature 535 (7612), 448-452, 2016 | 336 | 2016 |
| Structural basis for nucleotide exchange in heterotrimeric G proteins RO Dror, TJ Mildorf, D Hilger, A Manglik, DW Borhani, DH Arlow, ... Science 348 (6241), 1361-1365, 2015 | 317 | 2015 |
| Protein design and variant prediction using autoregressive generative models JE Shin, AJ Riesselman, AW Kollasch, C McMahon, E Simon, C Sander, ... Nature communications 12 (1), 2403, 2021 | 296 | 2021 |
| A genetically encoded biosensor reveals location bias of opioid drug action M Stoeber, D Jullié, BT Lobingier, T Laeremans, J Steyaert, PW Schiller, ... Neuron 98 (5), 963-976. e5, 2018 | 291 | 2018 |
| Allosteric coupling from G protein to the agonist-binding pocket in GPCRs BT DeVree, JP Mahoney, GA Vélez-Ruiz, SGF Rasmussen, AJ Kuszak, ... Nature 535 (7610), 182-186, 2016 | 270 | 2016 |
Aaron M. RingAssociate Professor, Fred Hutchinson Cancer Center在 fredhutch.org 的电子邮件经过验证
