| Phase II and phase III failures: 2013–2015 RK Harrison Nat Rev Drug Discov 15 (12), 817-818, 2016 | 565 | 2016 |
| Substrate specificities of the peptidyl prolyl cis-trans isomerase activities of cyclophilin and FK-506 binding protein: evidence for the existence of a family of distinct enzymes RK Harrison, RL Stein Biochemistry 29 (16), 3813-3816, 1990 | 401 | 1990 |
| The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin. FJ Dumont, MJ Staruch, SL Koprak, JJ Siekierka, CS Lin, R Harrison, ... The Journal of experimental medicine 176 (3), 751-760, 1992 | 337 | 1992 |
| Mechanistic studies of peptidyl prolyl cis-trans isomerase: evidence for catalysis by distortion RK Harrison, RL Stein Biochemistry 29 (7), 1684-1689, 1990 | 231 | 1990 |
| Mechanistic studies of enzymic and nonenzymic prolyl cis-trans isomerization RK Harrison, RL Stein Journal of the American Chemical Society 114 (9), 3464-3471, 1992 | 127 | 1992 |
| Generation and validation of rapid computational filters for CYP2D6 and CYP3A4 S Ekins, J Berbaum, RK Harrison Drug metabolism and disposition 31 (9), 1077-1080, 2003 | 121 | 2003 |
| Human fibroblast stromelysin catalytic domain: expression, purification, and characterization of a C-terminally truncated form AI Marcy, LL Eiberger, R Harrison, HK Chan, NI Hutchinson, ... Biochemistry 30 (26), 6476-6483, 1991 | 114 | 1991 |
| Inhibition of matrix metalloproteinases by N-carboxyalkyl peptides KT Chapman, IE Kopka, PL Durette, CK Esser, TJ Lanza, ... Journal of medicinal chemistry 36 (26), 4293-4301, 1993 | 95 | 1993 |
| Substrate specificity of the human matrix metalloproteinase stromelysin and the development of continuous fluorometric assays L Niedzwiecki, J Teahan, RK Harrison, RL Stein Biochemistry 31 (50), 12618-12623, 1992 | 95 | 1992 |
| Inhibition of Stromelysin-1 (MMP-3) by P1‘-Biphenylylethyl Carboxyalkyl Dipeptides CK Esser, RL Bugianesi, CG Caldwell, KT Chapman, PL Durette, ... Journal of medicinal chemistry 40 (6), 1026-1040, 1997 | 81 | 1997 |
| Mechanistic studies on the human matrix metalloproteinase stromelysin RK Harrison, B Chang, L Niedzwiecki, RL Stein Biochemistry 31 (44), 10757-10762, 1992 | 64 | 1992 |
| Phosphinic acid inhibitors of matrix metalloproteinases CG Caldwell, SP Sahoo, SA Polo, RR Eversole, TJ Lanza, SG Mills, ... Bioorganic & Medicinal Chemistry Letters 6 (3), 323-328, 1996 | 59 | 1996 |
| Substrate specificity of human fibroblast stromelysin. Hydrolysis of substance P and its analogs J Teahan, R Harrison, M Izquierdo, RL Stein Biochemistry 28 (21), 8497-8501, 1989 | 51 | 1989 |
| Effect of nitric oxide synthase substrate analog inhibitors on rat liver arginase CA Robertson, BG Green, L Niedzwiecki, RK Harrison, SK Grant Biochemical and biophysical research communications 197 (2), 523-528, 1993 | 50 | 1993 |
| Structure-based design and synthesis of 1, 3-oxazinan-2-one inhibitors of 11β-hydroxysteroid dehydrogenase type 1 Z Xu, CM Tice, W Zhao, S Cacatian, YJ Ye, SB Singh, P Lindblom, ... Journal of medicinal chemistry 54 (17), 6050-6062, 2011 | 47 | 2011 |
| Development of inhibitors of the aspartyl protease renin for the treatment of hypertension BB Scott, GM McGeehan, RK Harrison Current Protein and Peptide Science 7 (3), 241-254, 2006 | 45 | 2006 |
| Inhibition of stromelysin-1 (MMP-3) by peptidyl phosphinic acids JL Goulet, JF Kinneary, PL Durette, RL Stein, RK Harrison, ... Bioorganic & Medicinal Chemistry Letters 4 (10), 1221-1224, 1994 | 43 | 1994 |
| Discovery of VTP-27999, an alkyl amine renin inhibitor with potential for clinical utility L Jia, RD Simpson, J Yuan, Z Xu, W Zhao, S Cacatian, CM Tice, J Guo, ... ACS Medicinal Chemistry Letters 2 (10), 747-751, 2011 | 41 | 2011 |
| Development of a novel helicase assay using electrochemiluminescence L Zhang, G Schwartz, M O'Donnell, RK Harrison Analytical Biochemistry 293 (1), 31-37, 2001 | 41 | 2001 |
| A semicontinuous, high-performance liquid chromatography-based assay for stromelysin R Harrison, J Teahan, R Stein Analytical biochemistry 180 (1), 110-113, 1989 | 41 | 1989 |
