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The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease YH Youm, KY Nguyen, RW Grant, EL Goldberg, M Bodogai, D Kim, ... Nature medicine 21 (3), 263-269, 2015 | 1859 | 2015 |
Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases SM Man, R Karki, TD Kanneganti Immunological reviews 277 (1), 61-75, 2017 | 1446 | 2017 |
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages L Franchi, A Amer, M Body-Malapel, TD Kanneganti, N Özören, ... Nature immunology 7 (6), 576-582, 2006 | 1385 | 2006 |
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3 TD Kanneganti, N Özören, M Body-Malapel, A Amer, JH Park, L Franchi, ... Nature 440 (7081), 233-236, 2006 | 1345 | 2006 |
Intracellular NOD-like receptors in host defense and disease TD Kanneganti, M Lamkanfi, G Núñez Immunity 27 (4), 549-559, 2007 | 1318 | 2007 |
Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes R Karki, BR Sharma, S Tuladhar, EP Williams, L Zalduondo, P Samir, ... Cell 184 (1), 149-168. e17, 2021 | 1223 | 2021 |
The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis MH Zaki, KL Boyd, P Vogel, MB Kastan, M Lamkanfi, TD Kanneganti Immunity 32 (3), 379-391, 2010 | 1060 | 2010 |
Regulation of inflammasome activation SM Man, TD Kanneganti Immunological reviews 265 (1), 6-21, 2015 | 1048 | 2015 |
Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA TD Kanneganti, M Body-Malapel, A Amer, JH Park, J Whitfield, L Franchi, ... Journal of Biological Chemistry 281 (48), 36560-36568, 2006 | 840 | 2006 |
RETRACTED ARTICLE: Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins J Martinez, RKS Malireddi, Q Lu, LD Cunha, S Pelletier, S Gingras, ... Nature cell biology 17 (7), 893-906, 2015 | 830 | 2015 |
The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1 PG Thomas, P Dash, JR Aldridge, AH Ellebedy, C Reynolds, AJ Funk, ... Immunity 30 (4), 566-575, 2009 | 823 | 2009 |
Inflammasome is a central player in the induction of obesity and insulin resistance R Stienstra, JA Van Diepen, CJ Tack, MH Zaki, FL Van De Veerdonk, ... Proceedings of the National Academy of Sciences 108 (37), 15324-15329, 2011 | 784 | 2011 |
Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens KC El Kasmi, JE Qualls, JT Pesce, AM Smith, RW Thompson, ... Nature immunology 9 (12), 1399-1406, 2008 | 747 | 2008 |
The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation D Sharma, TD Kanneganti The Journal of cell biology 213 (6), 617, 2016 | 737 | 2016 |
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity R Stienstra, LAB Joosten, T Koenen, B Van Tits, JA Van Diepen, ... Cell metabolism 12 (6), 593-605, 2010 | 701 | 2010 |
Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling TD Kanneganti, M Lamkanfi, YG Kim, G Chen, JH Park, L Franchi, ... Immunity 26 (4), 433-443, 2007 | 681 | 2007 |
Converging roles of caspases in inflammasome activation, cell death and innate immunity SM Man, TD Kanneganti Nature Reviews Immunology 16 (1), 7-21, 2016 | 641 | 2016 |
Caspases in cell death, inflammation, and pyroptosis S Kesavardhana, RKS Malireddi, TD Kanneganti Annual review of immunology 38 (1), 567-595, 2020 | 633 | 2020 |
NLRP3 inflammasome in cancer and metabolic diseases BR Sharma, TD Kanneganti Nature immunology 22 (5), 550-559, 2021 | 630 | 2021 |