Neuritic regeneration and synaptic reconstruction induced by withanolide A T Kuboyama, C Tohda, K Komatsu British journal of pharmacology 144 (7), 961-971, 2005 | 412 | 2005 |
Search for natural products related to regeneration of the neuronal network C Tohda, T Kuboyama, K Komatsu Neurosignals 14 (1-2), 34-45, 2005 | 343 | 2005 |
Withanolide derivatives from the roots of Withania somnifera and their neurite outgrowth activities J Zhao, N Nakamura, M Hattori, T Kuboyama, C Tohda, K Komatsu Chemical and pharmaceutical bulletin 50 (6), 760-765, 2002 | 237 | 2002 |
Withanoside IV and its active metabolite, sominone, attenuate Aβ (25–35)‐induced neurodegeneration T Kuboyama, C Tohda, K Komatsu European Journal of Neuroscience 23 (6), 1417-1426, 2006 | 196 | 2006 |
Diosgenin is an exogenous activator of 1, 25D3-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice C Tohda, T Urano, M Umezaki, I Nemere, T Kuboyama Scientific reports 2 (1), 1-11, 2012 | 194 | 2012 |
Axon-or dendrite-predominant outgrowth induced by constituents from Ashwagandha T Kuboyama, C Tohda, J Zhao, N Nakamura, M Hattori, K Komatsu Neuroreport 13 (14), 1715-1720, 2002 | 157 | 2002 |
Effects of Ashwagandha (roots of Withania somnifera) on neurodegenerative diseases T Kuboyama, C Tohda, K Komatsu Biological and Pharmaceutical Bulletin 37 (6), 892-897, 2014 | 156 | 2014 |
Dendrite extension by methanol extract of Ashwagandha (roots of Withania somnifera) in SK-N-SH cells C Tohda, T Kuboyama, K Komatsu Neuroreport 11 (9), 1981-1985, 2000 | 141 | 2000 |
Current and future therapeutic strategies for functional repair of spinal cord injury C Tohda, T Kuboyama Pharmacology & therapeutics 132 (1), 57-71, 2011 | 122 | 2011 |
A systematic strategy for discovering a therapeutic drug for Alzheimer’s disease and its target molecule Z Yang, T Kuboyama, C Tohda Frontiers in pharmacology 8, 340, 2017 | 96 | 2017 |
A novel compound, denosomin, ameliorates spinal cord injury via axonal growth associated with astrocyte‐secreted vimentin K Teshigawara, T Kuboyama, M Shigyo, A Nagata, K Sugimoto, ... British journal of pharmacology 168 (4), 903-919, 2013 | 73 | 2013 |
Extracellular vimentin interacts with insulin-like growth factor 1 receptor to promote axonal growth M Shigyo, T Kuboyama, Y Sawai, M Tada-Umezaki, C Tohda Scientific reports 5 (1), 12055, 2015 | 68 | 2015 |
Naringenin promotes microglial M2 polarization and Aβ degradation enzyme expression Z Yang, T Kuboyama, C Tohda Phytotherapy Research 33 (4), 1114-1121, 2019 | 64 | 2019 |
HDAC3 inhibition ameliorates spinal cord injury by immunomodulation T Kuboyama, S Wahane, Y Huang, X Zhou, JK Wong, A Koemeter-Cox, ... Scientific reports 7 (1), 8641, 2017 | 54 | 2017 |
Kamikihi-to (KKT) rescues axonal and synaptic degeneration associated with memory impairment in a mouse model of Alzheimer's disease, 5XFAD C Tohda, R Nakada, T Urano, A Okonogi, T Kuboyama International Journal of Neuroscience 121 (12), 641-648, 2011 | 50 | 2011 |
Trigonelline recovers memory function in Alzheimer’s disease model mice: evidence of brain penetration and target molecule MM Farid, X Yang, T Kuboyama, C Tohda Scientific reports 10 (1), 16424, 2020 | 44 | 2020 |
Active Constituents from Drynaria fortunei Rhizomes on the Attenuation of Aβ25–35-Induced Axonal Atrophy ZY Yang, T Kuboyama, K Kazuma, K Konno, C Tohda Journal of natural products 78 (9), 2297-2300, 2015 | 40 | 2015 |
Polygalae radix extract prevents axonal degeneration and memory deficits in a transgenic mouse model of Alzheimer’s disease T Kuboyama, K Hirotsu, T Arai, H Yamasaki, C Tohda Frontiers in Pharmacology 8, 805, 2017 | 39 | 2017 |
Scientific basis for the anti-dementia drugs of constituents from Ashwagandha (Withania somnifera) C Tohda, K Komatsu, T Kuboyama J Tad Med 22, 176-182, 2005 | 38 | 2005 |
A novel Rac1-GSPT1 signaling pathway controls astrogliosis following central nervous system injury T Ishii, T Ueyama, M Shigyo, M Kohta, T Kondoh, T Kuboyama, T Uebi, ... Journal of Biological Chemistry 292 (4), 1240-1250, 2017 | 37 | 2017 |