Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors K Erreger, MT Geballe, A Kristensen, PE Chen, KB Hansen, CJ Lee, ... Molecular pharmacology 72 (4), 907-920, 2007 | 205 | 2007 |
Synaptic and extrasynaptic GABA transporters as targets for anti‐epileptic drugs KK Madsen, RP Clausen, OM Larsson, P Krogsgaard‐Larsen, ... Journal of neurochemistry 109, 139-144, 2009 | 126 | 2009 |
Inhibitors of histone demethylases B Lohse, JL Kristensen, LH Kristensen, K Agger, K Helin, M Gajhede, ... Bioorganic & medicinal chemistry 19 (12), 3625-3636, 2011 | 121 | 2011 |
α4βδ GABAA receptors are high-affinity targets for γ-hydroxybutyric acid (GHB) N Absalom, LF Eghorn, IS Villumsen, N Karim, T Bay, JV Olsen, ... Proceedings of the National Academy of Sciences 109 (33), 13404-13409, 2012 | 111 | 2012 |
Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino-4, 5, 6, 7-tetrahydrobenzo [d] isoxazol-3-ol analogues RP Clausen, EK Moltzen, J Perregaard, SM Lenz, C Sanchez, E Falch, ... Bioorganic & medicinal chemistry 13 (3), 895-908, 2005 | 92 | 2005 |
Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-D-aspartate receptors KB Hansen, N Tajima, R Risgaard, RE Perszyk, L Jørgensen, KM Vance, ... Molecular pharmacology 84 (1), 114-127, 2013 | 86 | 2013 |
Modified Peptides as Potent Inhibitors of the Postsynaptic Density-95/N-Methyl-d-Aspartate Receptor Interaction A Bach, CN Chi, TB Olsen, SW Pedersen, MU Røder, GF Pang, ... Journal of medicinal chemistry 51 (20), 6450-6459, 2008 | 83 | 2008 |
First demonstration of a functional role for central nervous system betaine/γ-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors … HS White, WP Watson, SL Hansen, S Slough, J Perregaard, A Sarup, ... Journal of Pharmacology and Experimental Therapeutics 312 (2), 866-874, 2005 | 78 | 2005 |
Structure-activity relationships of selective GABA uptake inhibitors S Hog, JR Greenwood, KB Madsen, OM Larsson, B Frolund, ... Current topics in medicinal chemistry 6 (17), 1861-1882, 2006 | 76 | 2006 |
Deletion of the betaine–GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice AC Lehre, NM Rowley, Y Zhou, S Holmseth, C Guo, T Holen, R Hua, ... Epilepsy research 95 (1-2), 70-81, 2011 | 71 | 2011 |
Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites BH Kaae, K Harpsøe, JS Kastrup, AC Sanz, DS Pickering, B Metzler, ... Chemistry & biology 14 (11), 1294-1303, 2007 | 71 | 2007 |
Chemoenzymatic synthesis and in situ application of S-adenosyl-L-methionine analogs M Thomsen, SB Vogensen, J Buchardt, MD Burkart, RP Clausen Organic & biomolecular chemistry 11 (43), 7606-7610, 2013 | 61 | 2013 |
Analogues of the Natural Product Sinefungin as Inhibitors of EHMT1 and EHMT2 K Devkota, B Lohse, Q Liu, MW Wang, D Stærk, J Berthelsen, RP Clausen ACS medicinal chemistry letters 5 (4), 293-297, 2014 | 60 | 2014 |
Selective GABA transporter inhibitors tiagabine and EF1502 exhibit mechanistic differences in their ability to modulate the ataxia and anticonvulsant action of the … KK Madsen, B Ebert, RP Clausen, P Krogsgaard-Larsen, A Schousboe, ... Journal of Pharmacology and Experimental Therapeutics 338 (1), 214-219, 2011 | 54 | 2011 |
Diagnostic evaluation of a nanobody with picomolar affinity toward the protease RgpB from Porphyromonas gingivalis PD Skottrup, P Leonard, JZ Kaczmarek, F Veillard, JJ Enghild, ... Analytical biochemistry 415 (2), 158-167, 2011 | 52 | 2011 |
Novel cyclic γ-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain P Wellendorph, S Høg, JR Greenwood, A de Lichtenberg, B Nielsen, ... Journal of Pharmacology and Experimental Therapeutics 315 (1), 346-351, 2005 | 52 | 2005 |
Differential role of AMPA receptors in mouse tests of antidepressant and anxiolytic action JT Andreasen, CM Fitzpatrick, M Larsen, L Skovgaard, SD Nielsen, ... Brain research 1601, 117-126, 2015 | 51 | 2015 |
A novel selective γ-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS RP Clausen, B Frølund, OM Larsson, A Schousboe, P Krogsgaard-Larsen, ... Neurochemistry international 48 (6-7), 637-642, 2006 | 50 | 2006 |
P2X7 receptor-mediated analgesia in cancer-induced bone pain S Falk, SD Schwab, M Frøsig-Jørgensen, RP Clausen, AH Dickenson, ... Neuroscience 291, 93-105, 2015 | 46 | 2015 |
Does increasing the ratio of AMPA-to-NMDA receptor mediated neurotransmission engender antidepressant action? Studies in the mouse forced swim and tail suspension tests JT Andreasen, M Gynther, A Rygaard, T Bøgelund, SD Nielsen, ... Neuroscience Letters 546, 6-10, 2013 | 46 | 2013 |