Human commensals producing a novel antibiotic impair pathogen colonization A Zipperer, MC Konnerth, C Laux, A Berscheid, D Janek, C Weidenmaier, ... Nature 535 (7613), 511-516, 2016 | 866 | 2016 |
Towards the sustainable discovery and development of new antibiotics M Miethke, M Pieroni, T Weber, M Brönstrup, P Hammann, L Halby, ... Nature Reviews Chemistry 5 (10), 726-749, 2021 | 622 | 2021 |
Dysregulation of bacterial proteolytic machinery by a new class of antibiotics H Brötz-Oesterhelt, D Beyer, HP Kroll, R Endermann, C Ladel, ... Nature medicine 11 (10), 1082-1087, 2005 | 575 | 2005 |
Proteomic approach to understanding antibiotic action JE Bandow, H Brötz, LIO Leichert, H Labischinski, M Hecker Antimicrobial agents and chemotherapy 47 (3), 948-955, 2003 | 565 | 2003 |
Role of lipid‐bound peptidoglycan precursors in the formation of pores by nisin, epidermin and other lantibiotics H Brötz, M Josten, I Wiedemann, U Schneider, F Götz, G Bierbaum, ... Molecular microbiology 30 (2), 317-327, 1998 | 543 | 1998 |
The lantibiotic mersacidin inhibits peptidoglycan synthesis by targeting lipid II H Brötz, G Bierbaum, K Leopold, PE Reynolds, HG Sahl Antimicrobial agents and chemotherapy 42 (1), 154-160, 1998 | 524 | 1998 |
Small cationic antimicrobial peptides delocalize peripheral membrane proteins M Wenzel, AI Chiriac, A Otto, D Zweytick, C May, C Schumacher, R Gust, ... Proceedings of the National Academy of Sciences 111 (14), E1409-E1418, 2014 | 328 | 2014 |
The lantibiotic mersacidin inhibits peptidoglycan biosynthesis at the level of transglycosylation H Brötz, G Bierbaum, PE Reynolds, HG Sahl European Journal of Biochemistry 246 (1), 193-199, 1997 | 275 | 1997 |
Inducing Secondary Metabolite Production by the Endophytic Fungus Fusarium tricinctum through Coculture with Bacillus subtilis ARB Ola, D Thomy, D Lai, H Brötz-Oesterhelt, P Proksch Journal of natural products 76 (11), 2094-2099, 2013 | 262 | 2013 |
The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease J Kirstein, A Hoffmann, H Lilie, R Schmidt, H Rübsamen‐Waigmann, ... EMBO molecular medicine 1 (1), 37-49, 2009 | 245 | 2009 |
Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism BG Lee, EY Park, KE Lee, H Jeon, KH Sung, H Paulsen, ... Nature structural & molecular biology 17 (4), 471-478, 2010 | 243 | 2010 |
The microbiome-shaping roles of bacteriocins S Heilbronner, B Krismer, H Brötz-Oesterhelt, A Peschel Nature Reviews Microbiology 19 (11), 726-739, 2021 | 228 | 2021 |
Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ P Sass, M Josten, K Famulla, G Schiffer, HG Sahl, L Hamoen, ... Proceedings of the National Academy of Sciences 108 (42), 17474-17479, 2011 | 219 | 2011 |
Mode of action of the lantibiotic mersacidin: inhibition of peptidoglycan biosynthesis via a novel mechanism? H Brötz, G Bierbaum, A Markus, E Molitor, HG Sahl Antimicrobial Agents and Chemotherapy 39 (3), 714-719, 1995 | 210 | 1995 |
New insights into the mechanism of action of lantibiotics—diverse biological effects by binding to the same molecular target H Brötz, HG Sahl Journal of Antimicrobial Chemotherapy 46 (1), 1-6, 2000 | 176 | 2000 |
How many modes of action should an antibiotic have? H Brötz-Oesterhelt, NA Brunner Current opinion in pharmacology 8 (5), 564-573, 2008 | 158 | 2008 |
Specific and potent inhibition of NAD+-dependent DNA ligase by pyridochromanones H Brötz-Oesterhelt, I Knezevic, S Bartel, T Lampe, U Warnecke-Eberz, ... Journal of Biological Chemistry 278 (41), 39435-39442, 2003 | 141 | 2003 |
Postgenomic strategies in antibacterial drug discovery H Brötz-Oesterhelt, P Sass Future microbiology 5 (10), 1553-1579, 2010 | 138 | 2010 |
AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control M Gersch, K Famulla, M Dahmen, C Göbl, I Malik, K Richter, VS Korotkov, ... Nature communications 6 (1), 6320, 2015 | 128 | 2015 |
Identification of novel essential Escherichia coli genes conserved among pathogenic bacteria C Freiberg, B Wieland, F Spaltmann, K Ehlert, H Brotz, H Labischinski Journal of molecular microbiology and biotechnology 3 (3), 483-489, 2001 | 125 | 2001 |