关注
Gary Spencer
Gary Spencer
CRUK Manchester Institute
在 cruk.manchester.ac.uk 的电子邮件经过验证
标题
引用次数
引用次数
年份
The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells
WJ Harris, X Huang, JT Lynch, GJ Spencer, JR Hitchin, Y Li, F Ciceri, ...
Cancer cell 21 (4), 473-487, 2012
6482012
Expression profiling and functional analysis of wnt signaling mechanisms in mesenchymal stem cells
SL Etheridge, GJ Spencer, DJ Heath, PG Genever
Stem cells 22 (5), 849-860, 2004
4702004
Wnt signalling in osteoblasts regulates expression of the receptor activator of NFκB ligand and inhibits osteoclastogenesis in vitro
GJ Spencer, JC Utting, SL Etheridge, TR Arnett, PG Genever
Journal of cell science 119 (7), 1283-1296, 2006
4232006
Targeting the RNA m6A reader YTHDF2 selectively compromises cancer stem cells in acute myeloid leukemia
J Paris, M Morgan, J Campos, GJ Spencer, A Shmakova, I Ivanova, ...
Cell stem cell 25 (1), 137-148. e6, 2019
4062019
Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells
TCP Somervaille, CJ Matheny, GJ Spencer, M Iwasaki, JL Rinn, ...
Cell stem cell 4 (2), 129-140, 2009
4002009
Enhancer activation by pharmacologic displacement of LSD1 from GFI1 induces differentiation in acute myeloid leukemia
A Maiques-Diaz, GJ Spencer, JT Lynch, F Ciceri, EL Williams, ...
Cell reports 22 (13), 3641-3659, 2018
1852018
Evidence for targeted vesicular glutamate exocytosis in osteoblasts
PS Bhangu, PG Genever, GJ Spencer, TS Grewal, TM Skerry
Bone 29 (1), 16-23, 2001
1062001
A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival
JG Jude, GJ Spencer, X Huang, TDD Somerville, DR Jones, N Divecha, ...
Oncogene 34 (10), 1253-1262, 2015
842015
Frequent derepression of the mesenchymal transcription factor gene FOXC1 in acute myeloid leukemia
TDD Somerville, DH Wiseman, GJ Spencer, X Huang, JT Lynch, ...
Cancer cell 28 (3), 329-342, 2015
682015
Emerging neuroskeletal signalling pathways: a review
GJ Spencer, IS Hitchcock, PG Genever
FEBS letters 559 (1-3), 6-12, 2004
592004
Discovery and optimization of allosteric inhibitors of mutant isocitrate dehydrogenase 1 (R132H IDH1) displaying activity in human acute myeloid leukemia cells
S Jones, J Ahmet, K Ayton, M Ball, M Cockerill, E Fairweather, N Hamilton, ...
Journal of Medicinal Chemistry 59 (24), 11120-11137, 2016
532016
Current perspectives on NMDA-type glutamate signalling in bone
GJ Spencer, CJ McGrath, PG Genever
The International Journal of Biochemistry & Cell Biology 39 (6), 1089-1104, 2007
512007
Long-term potentiation in bone–a role for glutamate in strain-induced cellular memory?
GJ Spencer, PG Genever
BMC cell biology 4, 1-4, 2003
472003
Development of (4-cyanophenyl) glycine derivatives as reversible inhibitors of lysine specific demethylase 1
DP Mould, C Alli, U Bremberg, S Cartic, AM Jordan, M Geitmann, ...
Journal of Medicinal Chemistry 60 (19), 7984-7999, 2017
462017
Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells
X Huang, GJ Spencer, JT Lynch, F Ciceri, TDD Somerville, ...
Leukemia 28 (5), 1081-1091, 2014
422014
Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia
G Deb, B Wingelhofer, FMR Amaral, A Maiques-Diaz, JA Chadwick, ...
Leukemia 34 (5), 1266-1277, 2020
402020
LSD1 inhibitors disrupt the GFI1 transcription repressor complex
A Maiques-Diaz, JT Lynch, GJ Spencer, TCP Somervaille
Molecular & cellular oncology 5 (4), e1481813, 2018
252018
Derepression of the Iroquois homeodomain transcription factor gene IRX3 confers differentiation block in acute leukemia
TDD Somerville, F Simeoni, JA Chadwick, EL Williams, GJ Spencer, ...
Cell Reports 22 (3), 638-652, 2018
242018
CCS1477: a novel small molecule inhibitor of p300/CBP bromodomain for the treatment of acute myeloid leukaemia and multiple myeloma
N Brooks, M Raja, BW Young, GJ Spencer, TCP Somervaille, NA Pegg
Blood 134, 2560, 2019
222019
Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia
F Simeoni, I Romero-Camarero, F Camera, FMR Amaral, OJ Sinclair, ...
Cell Reports 36 (12), 2021
202021
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