Testing gene function early in the B cell lineage in mb1-cre mice E Hobeika, S Thiemann, B Storch, H Jumaa, PJ Nielsen, R Pelanda, ... Proceedings of the National Academy of Sciences 103 (37), 13789-13794, 2006 | 636 | 2006 |
Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling MD Minden, R Übelhart, D Schneider, T Wossning, MP Bach, M Buchner, ... Nature 489 (7415), 309-312, 2012 | 633 | 2012 |
Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling S Herzog, M Reth, H Jumaa Nature Reviews Immunology 9 (3), 195-205, 2009 | 456 | 2009 |
Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65 H Jumaa, B Wollscheid, M Mitterer, J Wienands, M Reth, PJ Nielsen Immunity 11 (5), 547-554, 1999 | 361 | 1999 |
SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation J Wienands, J Schweikert, B Wollscheid, H Jumaa, PJ Nielsen, M Reth The Journal of experimental medicine 188 (4), 791-795, 1998 | 358 | 1998 |
The splicing factor SRp20 modifies splicing of its own mRNA and ASF/SF2 antagonizes this regulation H Jumaa, PJ Nielsen The EMBO journal, 1997 | 331 | 1997 |
Girls homozygous for an IL-2–inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation K Huck, O Feyen, T Niehues, F Rüschendorf, N Hübner, HJ Laws, ... The Journal of clinical investigation 119 (5), 1350-1358, 2009 | 323 | 2009 |
Yin Yang 1 is a critical regulator of B-cell development H Liu, M Schmidt-Supprian, Y Shi, E Hobeika, N Barteneva, H Jumaa, ... Genes & development 21 (10), 1179-1189, 2007 | 281 | 2007 |
Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits EC Thompson, BS Cobb, P Sabbattini, S Meixlsperger, V Parelho, ... Immunity 26 (3), 335-344, 2007 | 230 | 2007 |
The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion A Flemming, T Brummer, M Reth, H Jumaa Nature immunology 4 (1), 38-43, 2003 | 225 | 2003 |
Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia M Buchner, S Fuchs, G Prinz, D Pfeifer, K Bartholomé, M Burger, ... Cancer research 69 (13), 5424-5432, 2009 | 219 | 2009 |
BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR–ABL1 kinase inhibition C Duy, C Hurtz, S Shojaee, L Cerchietti, H Geng, S Swaminathan, ... Nature 473 (7347), 384-388, 2011 | 216 | 2011 |
Spleen tyrosine kinase inhibition prevents chemokine-and integrin-mediated stromal protective effects in chronic lymphocytic leukemia M Buchner, C Baer, G Prinz, C Dierks, M Burger, T Zenz, S Stilgenbauer, ... Blood, The Journal of the American Society of Hematology 115 (22), 4497-4506, 2010 | 214 | 2010 |
The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia L Klemm, C Duy, I Iacobucci, S Kuchen, G von Levetzow, N Feldhahn, ... Cancer cell 16 (3), 232-245, 2009 | 198 | 2009 |
BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia C Hurtz, K Hatzi, L Cerchietti, M Braig, E Park, Y Kim, S Herzog, ... Journal of Experimental Medicine 208 (11), 2163-2174, 2011 | 193 | 2011 |
Blastocyst formation is blocked in mouse embryos lacking the splicing factor SRp20 H Jumaa, G Wei, PJ Nielsen Current Biology 9 (16), 899-902, 1999 | 193 | 1999 |
SLP-65 regulates immunoglobulin light chain gene recombination through the PI (3) K-PKB-Foxo pathway S Herzog, E Hug, S Meixlsperger, JH Paik, RA DePinho, M Reth, ... Nature immunology 9 (6), 623-631, 2008 | 192 | 2008 |
Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia H Jumaa, L Bossaller, K Portugal, B Storch, M Lotz, A Flemming, ... Nature 423 (6938), 452-456, 2003 | 162 | 2003 |
Role of PI3K in the generation and survival of B cells M Werner, E Hobeika, H Jumaa Immunological reviews 237 (1), 55-71, 2010 | 155 | 2010 |
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia Z Chen, S Shojaee, M Buchner, H Geng, JW Lee, L Klemm, B Titz, ... Nature 521 (7552), 357-361, 2015 | 151 | 2015 |