| Cloning and heterologous expression of the cyclooctatin biosynthetic gene cluster afford a diterpene cyclase and two p450 hydroxylases SY Kim, P Zhao, M Igarashi, R Sawa, T Tomita, M Nishiyama, ... Chemistry & biology 16 (7), 736-743, 2009 | 118 | 2009 |
| Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway E Okamura, T Tomita, R Sawa, M Nishiyama, T Kuzuyama Proceedings of the National Academy of Sciences 107 (25), 11265-11270, 2010 | 110 | 2010 |
| An unusual terpene cyclization mechanism involving a carbon–carbon bond rearrangement A Meguro, Y Motoyoshi, K Teramoto, S Ueda, Y Totsuka, Y Ando, ... Angewandte Chemie International Edition 54 (14), 4353-4356, 2015 | 98 | 2015 |
| The herbicide ketoclomazone inhibits 1-deoxy-D-xylulose 5-phosphate synthase in the 2-C-methyl-D-erythritol 4-phosphate pathway and shows antibacterial activity against … Y Matsue, H Mizuno, T Tomita, T Asami, M Nishiyama, T Kuzuyama The Journal of antibiotics 63 (10), 583-588, 2010 | 79 | 2010 |
| Discovery of unprecedented hydrazine-forming machinery in bacteria K Matsuda, T Tomita, K Shin-Ya, T Wakimoto, T Kuzuyama, M Nishiyama Journal of the American Chemical Society 140 (29), 9083-9086, 2018 | 71 | 2018 |
| Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus A Horie, T Tomita, A Saiki, H Kono, H Taka, R Mineki, T Fujimura, ... Nature Chemical Biology 5 (9), 673-679, 2009 | 59 | 2009 |
| Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus T Ouchi, T Tomita, A Horie, A Yoshida, K Takahashi, H Nishida, K Lassak, ... Nature Chemical Biology 9 (4), 277-283, 2013 | 56 | 2013 |
| Structural insight into concerted inhibition of α2β2-type aspartate kinase from Corynebacterium glutamicum A Yoshida, T Tomita, T Kurihara, S Fushinobu, T Kuzuyama, M Nishiyama Journal of molecular biology 368 (2), 521-536, 2007 | 56 | 2007 |
| Identification and characterization of bacterial diterpene cyclases that synthesize the cembrane skeleton A Meguro, T Tomita, M Nishiyama, T Kuzuyama ChemBioChem 14 (3), 316, 2013 | 54 | 2013 |
| Theoretical study of sesterfisherol biosynthesis: computational prediction of key amino acid residue in terpene synthase H Sato, K Narita, A Minami, M Yamazaki, C Wang, H Suemune, S Nagano, ... Scientific Reports 8 (1), 2473, 2018 | 49 | 2018 |
| Mechanism of concerted inhibition of α2β2-type hetero-oligomeric aspartate kinase from Corynebacterium glutamicum A Yoshida, T Tomita, T Kuzuyama, M Nishiyama Journal of biological chemistry 285 (35), 27477-27486, 2010 | 48 | 2010 |
| Structural basis for leucine-induced allosteric activation of glutamate dehydrogenase T Tomita, T Kuzuyama, M Nishiyama Journal of Biological Chemistry 286 (43), 37406-37413, 2011 | 45 | 2011 |
| Functional characterization of the promiscuous prenyltransferase responsible for furaquinocin biosynthesis: identification of a physiological polyketide substrate and its … T Kumano, T Tomita, M Nishiyama, T Kuzuyama Journal of biological chemistry 285 (51), 39663-39671, 2010 | 43 | 2010 |
| Mechanism of Substrate Recognition and Insight into Feedback Inhibition of Homocitrate Synthase from Thermus thermophilus2 T Okada, T Tomita, AP Wulandari, T Kuzuyama, M Nishiyama Journal of biological chemistry 285 (6), 4195-4205, 2010 | 40 | 2010 |
| Structural insights into the CotB2-catalyzed cyclization of geranylgeranyl diphosphate to the diterpene cyclooctat-9-en-7-ol T Tomita, SY Kim, K Teramoto, A Meguro, T Ozaki, A Yoshida, ... ACS chemical biology 12 (6), 1621-1628, 2017 | 39 | 2017 |
| Genome mining of amino group carrier protein-mediated machinery: discovery and biosynthetic characterization of a natural product with unique hydrazone unit K Matsuda, F Hasebe, Y Shiwa, Y Kanesaki, T Tomita, H Yoshikawa, ... ACS Chemical Biology 12 (1), 124-131, 2017 | 38 | 2017 |
| Amino-group carrier-protein-mediated secondary metabolite biosynthesis in Streptomyces F Hasebe, K Matsuda, T Shiraishi, Y Futamura, T Nakano, T Tomita, ... Nature Chemical Biology 12 (11), 967-972, 2016 | 35 | 2016 |
| Kinetics and product analysis of the reaction catalysed by recombinant homoaconitase from Thermus thermophilus Y Jia, T Tomita, K Yamauchi, M Nishiyama, DRJ Palmer Biochemical Journal 396 (3), 479-485, 2006 | 30 | 2006 |
| A suicide enzyme catalyzes multiple reactions for biotin biosynthesis in cyanobacteria K Sakaki, K Ohishi, T Shimizu, I Kobayashi, N Mori, K Matsuda, T Tomita, ... Nature Chemical Biology 16 (4), 415-422, 2020 | 24 | 2020 |
| Crystal structures of the regulatory subunit of Thr‐sensitive aspartate kinase from Thermus thermophilus A Yoshida, T Tomita, H Kono, S Fushinobu, T Kuzuyama, M Nishiyama The FEBS Journal 276 (11), 3124-3136, 2009 | 23 | 2009 |
