| L-Thymidine is phosphorylated by herpes simplex virus type 1 thymidine kinase and inhibits viral growth S Spadari, G Maga, F Focher, G Ciarrocchi, R Manservigi, F Arcamone, ... Journal of medicinal chemistry 35 (22), 4214-4220, 1992 | 153 | 1992 |
| The specific binding of nuclear protein (s) to the cAMP responsive element (CRE) sequence (TGACGTCA) is reduced by the misincorporation of U and increased by the deamination of C A Verri, P Mazzarello, G Biamonti, S Spadari, F Focher Nucleic acids research 18 (19), 5775-5780, 1990 | 96 | 1990 |
| Thymidine phosphorylase: a two-face Janus in anticancer chemotherapy F Focher, S Spadari Current cancer drug targets 1 (2), 141-153, 2001 | 90 | 2001 |
| Activity profiles of enzymes that control the uracil incorporation into DNA during neuronal development F Focher, P Mazzarello, A Verri, U Hübscher, S Spadari Mutation Research/DNAging 237 (2), 65-73, 1990 | 78 | 1990 |
| N2-Phenyldeoxyguanosine: a novel selective inhibitor of herpes simplex thymiding kinase F Focher, C Hildebrand, S Freese, G Ciarrocchi, T Noonan, S Sangalli, ... Journal of medicinal chemistry 31 (8), 1496-1500, 1988 | 75 | 1988 |
| Calf thymus DNA polymerase δ independent of proliferating cell nuclear antigen (PCNA) F Focher, M Gassmann, P Hafkmeyer, E Ferrari, S Spadari, U Hübscher Nucleic acids research 17 (5), 1805-1821, 1989 | 72 | 1989 |
| DNA ligase I gene expression during differentiation and cell proliferation A Montecucco, G Biamonti, E Savini, F Focher, S Spadari, G Ciarrocchi Nucleic acids research 20 (23), 6209-6214, 1992 | 65 | 1992 |
| Lack of enantiospecificity of human 2′-deoxycytidine kinase: relevance for the activation of β-L-deoxycytidine analogs as antineoplastic and antiviral agents A Verri, F Focher, G Priori, G Gosselin, JL Imbach, M Capobianco, ... Molecular Pharmacology 51 (1), 132-138, 1997 | 64 | 1997 |
| Calf thymus DNA polymerase δ: purification, biochemical and functional properties of the enzyme after its separation from DNA polymerase α, a DNA dependent ATPase and … F Focher, S Spadari, B Ginelli, M Hottiger, M Gassmann, U Hübscher Nucleic acids research 16 (14), 6279-6295, 1988 | 62 | 1988 |
| Stereospecificity of human DNA polymerases α, β, γ, § and ɛ, HIV-reverse transcriptase, HSV-DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase … F Focher, G Maga, A Bendiscioli, M Capobianco, F Colonna, A Garbesi, ... Nucleic acids research 23 (15), 2840-2847, 1995 | 60* | 1995 |
| DNA repair mechanisms in neurological diseases: facts and hypotheses P Mazzarello, M Poloni, S Spadari, F Focher Journal of the neurological sciences 112 (1-2), 4-14, 1992 | 60 | 1992 |
| Structure-activity relationships of N2-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases C Hildebrand, D Sandoli, F Focher, J Gambino, G Ciarrocchi, S Spadari, ... Journal of medicinal chemistry 33 (1), 203-206, 1990 | 59 | 1990 |
| Control of cell division by aphidicolin without adverse effects upon resting cells. S Spadari, F Focher, F Sala, G Ciarrocchi, G Koch, A Falaschi, ... Arzneimittel-forschung 35 (7), 1108-1116, 1985 | 58 | 1985 |
| Inhibitor analysis of calf thymus DNA polymerases α, δ and ϵ GE Wright, U Hübscher, NN Khan, F Focher, A Verri FEBS letters 341 (1), 128-130, 1994 | 56 | 1994 |
| Herpes simplex virus type 1 uracil-DNA glycosylase: isolation and selective inhibition by novel uracil derivatives F Focher, A Verri, S Spadari, R Manservigi, J Gambino, GE Wright Biochemical Journal 292 (3), 883-889, 1993 | 54 | 1993 |
| Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure− activity relationships and antiherpetic activity in vivo A Manikowski, A Verri, A Lossani, BM Gebhardt, J Gambino, F Focher, ... Journal of medicinal chemistry 48 (11), 3919-3929, 2005 | 53 | 2005 |
| Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases H Xu, G Maga, F Focher, ER Smith, S Spadari, J Gambino, GE Wright Journal of medicinal chemistry 38 (1), 49-57, 1995 | 53 | 1995 |
| Do DNA polymerases δ and α act coordinately as leading and lagging strand replicases? F Focher, E Ferrari, S Spadari, U Hübscher FEBS letters 229 (1), 6-10, 1988 | 52 | 1988 |
| DNA polymerases and DNA topoisomerases as targets for the development of anticancer drugs. S Spadari, G Pedrali-Noy, F Focher, A Montecucco, T Bordoni, C Geroni, ... Anticancer research 6 (5), 935-940, 1986 | 52 | 1986 |
| Uracil in Oris of herpes simplex 1 alters its specific recognition by origin binding protein (OBP): does virus induced uracil-DNA glycosylase play a key role in viral … F Focher, A Verri, S Verzeletti, P Mazzarello, S Spadari Chromosoma 102, S67-S71, 1992 | 51 | 1992 |
Silvio SpadariInstitute of Molecular Genetics, CNR, Pavia, Italy在 igm.cnr.it 的电子邮件经过验证
