A-803467, a potent and selective Nav1. 8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat MF Jarvis, P Honore, CC Shieh, M Chapman, S Joshi, XF Zhang, M Kort, ... Proceedings of the National Academy of Sciences 104 (20), 8520-8525, 2007 | 621 | 2007 |
A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat MF Jarvis, EC Burgard, S McGaraughty, P Honore, K Lynch, TJ Brennan, ... Proceedings of the National Academy of Sciences 99 (26), 17179-17184, 2002 | 557 | 2002 |
Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation J Chen, SK Joshi, S DiDomenico, RJ Perner, JP Mikusa, DM Gauvin, ... Pain 152 (5), 1165-1172, 2011 | 314 | 2011 |
P2X7-related modulation of pathological nociception in rats S McGaraughty, KL Chu, MT Namovic, DL Donnelly-Roberts, RR Harris, ... Neuroscience 146 (4), 1817-1828, 2007 | 267 | 2007 |
Effects of A‐317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and … S McGaraughty, CT Wismer, CZ Zhu, J Mikusa, P Honore, KL Chu, ... British journal of pharmacology 140 (8), 1381-1388, 2003 | 218 | 2003 |
Painful purinergic receptors D Donnelly-Roberts, S McGaraughty, CC Shieh, P Honore, MF Jarvis Journal of Pharmacology and Experimental Therapeutics 324 (2), 409-415, 2008 | 202 | 2008 |
TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats S McGaraughty, KL Chu, RJ Perner, S DiDomenico, ME Kort, PR Kym Molecular pain 6, 1744-8069-6-14, 2010 | 195 | 2010 |
Circuitry underlying antiopioid actions of cholecystokinin within the rostral ventromedial medulla MM Heinricher, S McGaraughty, V Tortorici Journal of neurophysiology 85 (1), 280-286, 2001 | 144 | 2001 |
Capsaicin infused into the PAG affects rat tail flick responses to noxious heat and alters neuronal firing in the RVM S McGaraughty, KL Chu, RS Bitner, B Martino, RE Kouhen, P Han, ... Journal of neurophysiology 90 (4), 2702-2710, 2003 | 137 | 2003 |
Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial MC Rowbotham, W Nothaft, WR Duan, Y Wang, C Faltynek, ... Pain 152 (5), 1192-1200, 2011 | 127 | 2011 |
Microinjection of morphine into various amygdaloid nuclei differentially affects nociceptive responsiveness and RVM neuronal activity S McGaraughty, MM Heinricher Pain 96 (1-2), 153-162, 2002 | 122 | 2002 |
Anticonvulsant and antinociceptive actions of novel adenosine kinase inhibitors S McGaraughty, M Cowart, MF Jarvis, RF Berman Current topics in medicinal chemistry 5 (1), 43-58, 2005 | 120 | 2005 |
Circuitry underlying antiopioid actions of orphanin FQ in the rostral ventromedial medulla MM Heinricher, S McGaraughty, DK Grandy Journal of Neurophysiology 78 (6), 3351-3358, 1997 | 119 | 1997 |
Design of adenosine kinase inhibitors from the NMR-based screening of fragments PJ Hajduk, A Gomtsyan, S Didomenico, M Cowart, EK Bayburt, ... Journal of medicinal chemistry 43 (25), 4781-4786, 2000 | 103 | 2000 |
The role of excitatory amino acid transmission within the rostral ventromedial medulla in the antinociceptive actions of systemically administered morphine MM Heinricher, S McGaraughty, DA Farr Pain 81 (1-2), 57-65, 1999 | 84 | 1999 |
A selective Nav1. 8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3, 5-dimethoxyphenyl) furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats S McGaraughty, KL Chu, MJC Scanio, ME Kort, CR Faltynek, MF Jarvis Journal of Pharmacology and Experimental Therapeutics 324 (3), 1204-1211, 2008 | 82 | 2008 |
A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats MF Jarvis, VE Scott, S McGaraughty, KL Chu, J Xu, W Niforatos, I Milicic, ... Biochemical pharmacology 89 (4), 536-544, 2014 | 77 | 2014 |
Lesions of the periaqueductal gray disrupt input to the rostral ventromedial medulla following microinjections of morphine into the medial or basolateral nuclei of the amygdala S McGaraughty, DA Farr, MM Heinricher Brain research 1009 (1-2), 223-227, 2004 | 73 | 2004 |
5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl) pyrido [2, 3-d] pyrimidin-4-ylamine: structure–activity relationships of 7-substituted heteroaryl analogs as non-nucleoside … MA Matulenko, CH Lee, M Jiang, RR Frey, MD Cowart, EK Bayburt, ... Bioorganic & medicinal chemistry 13 (11), 3705-3720, 2005 | 69 | 2005 |
Analgesic and anti-inflammatory effects of A-286501, a novel orally active adenosine kinase inhibitor MF Jarvis, H Yu, S McGaraughty, CT Wismer, J Mikusa, C Zhu, K Chu, ... Pain 96 (1-2), 107-118, 2002 | 67 | 2002 |