Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease F Fattahi, JA Steinbeck, S Kriks, J Tchieu, B Zimmer, S Kishinevsky, ... Nature 531 (7592), 105, 2016 | 315 | 2016 |
Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells Y Qi, XJ Zhang, N Renier, Z Wu, T Atkin, Z Sun, MZ Ozair, J Tchieu, ... Nature biotechnology 35 (2), 154, 2017 | 238 | 2017 |
A Modular Platform for Differentiation of Human PSCs into All Major Ectodermal Lineages J Tchieu, B Zimmer, F Fattahi, S Amin, N Zeltner, S Chen, L Studer Cell Stem Cell 21 (3), 399-410. e7, 2017 | 204 | 2017 |
Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use. M Aschner, S Ceccatelli, M Daneshian, E Fritsche, N Hasiwa, T Hartung, ... ALTEX, 2016 | 153 | 2016 |
Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing P Kügler, B Zimmer, T Waldmann, B Baudis, S Ilmjärv, J Hescheler, ... Alternatives to animal experimentation: ALTEX 27 (1), 16-42, 2010 | 131 | 2010 |
Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing B Zimmer, PB Kuegler, B Baudis, A Genewsky, V Tanavde, W Koh, B Tan, ... Cell death and differentiation 18 (3), 383, 2011 | 129 | 2011 |
Evaluation of developmental toxicants and signaling pathways in a functional test based on the migration of human neural crest cells B Zimmer, G Lee, NV Balmer, K Meganathan, A Sachinidis, L Studer, ... Environmental health perspectives 120 (8), 1116, 2012 | 123 | 2012 |
Specification of functional cranial placode derivatives from human pluripotent stem cells Z Dincer, J Piao, L Niu, Y Ganat, S Kriks, B Zimmer, SH Shi, V Tabar, ... Cell reports 5 (5), 1387-1402, 2013 | 117 | 2013 |
Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome NV Balmer, MK Weng, B Zimmer, VN Ivanova, SM Chambers, ... Human Molecular Genetics 21 (18), 4104-4114, 2012 | 116 | 2012 |
Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs D Cornacchia, C Zhang, B Zimmer, SY Chung, Y Fan, MA Soliman, ... Cell stem cell, 2019 | 111 | 2019 |
Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection SY Zhang, NE Clark, CA Freije, E Pauwels, AJ Taggart, S Okada, ... Cell 172 (5), 952-965. e18, 2018 | 107 | 2018 |
Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis FG Lafaille, O Harschnitz, YS Lee, P Zhang, ML Hasek, G Kerner, Y Itan, ... Nature Medicine 25 (12), 1873-1884, 2019 | 103 | 2019 |
Compound selection for in vitro modeling of developmental neurotoxicity S Kadereit, B Zimmer, C van Thriel, JG Hengstler, M Leist Front Biosci 17, 2442-2460, 2012 | 95 | 2012 |
Sensitivity of dopaminergic neuron differentiation from stem cells to chronic low-dose methylmercury exposure B Zimmer, S Schildknecht, PB Kuegler, V Tanavde, S Kadereit, M Leist Toxicological Sciences 121 (2), 357-367, 2011 | 87 | 2011 |
Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery B Zimmer, G Pallocca, N Dreser, S Foerster, T Waldmann, J Westerhout, ... Archives of toxicology 88 (5), 1109-1126, 2014 | 80 | 2014 |
Human iPSC-derived trigeminal neurons lack constitutive TLR3-dependent immunity that protects cortical neurons from HSV-1 infection B Zimmer, O Ewaleifoh, O Harschnitz, YS Lee, C Peneau, JL McAlpine, ... Proceedings of the National Academy of Sciences 115 (37), E8775-E8782, 2018 | 66 | 2018 |
Derivation of Diverse Hormone-Releasing Pituitary Cells from Human Pluripotent Stem Cells B Zimmer, J Piao, K Ramnarine, MJ Tomishima, V Tabar, L Studer Stem Cell Reports 6 (6), 858-872, 2016 | 65 | 2016 |
Capturing the biology of disease severity in a PSC-based model of familial dysautonomia N Zeltner, F Fattahi, NC Dubois, N Saurat, F Lafaille, L Shang, B Zimmer, ... Nature medicine 22 (12), 1421, 2016 | 64 | 2016 |
GFAP‐independent inflammatory competence and trophic functions of astrocytes generated from murine embryonic stem cells PB Kuegler, BA Baumann, B Zimmer, S Keller, A Marx, S Kadereit, M Leist Glia 60 (2), 218-228, 2012 | 48 | 2012 |
Acrylamide alters neurotransmitter induced calcium responses in murine ESC-derived and primary neurons J Sisnaiske, V Hausherr, AK Krug, B Zimmer, JG Hengstler, M Leist, ... Neurotoxicology 43, 117-126, 2014 | 45 | 2014 |