Dephosphorylation of endotoxin by alkaline phosphatase in vivo. K Poelstra, WW Bakker, PA Klok, JA Kamps, MJ Hardonk, DK Meijer The American journal of pathology 151 (4), 1163, 1997 | 277 | 1997 |
Removal of phosphate from lipid A as a strategy to detoxify lipopolysaccharide H Bentala, WR Verweij, A Huizinga-Van der Vlag, ... Shock 18 (6), 561-566, 2002 | 269 | 2002 |
Cytokine regulation of pro-and anti-apoptotic genes in rat hepatocytes: NF-κB-regulated inhibitor of apoptosis protein 2 (cIAP2) prevents apoptosis MH Schoemaker, JE Ros, M Homan, C Trautwein, P Liston, K Poelstra, ... Journal of hepatology 36 (6), 742-750, 2002 | 240 | 2002 |
A physiologic function for alkaline phosphatase: endotoxin detoxification. K Poelstra, WW Bakker, PA Klok, MJ Hardonk, DK Meijer Laboratory investigation; a journal of technical methods and pathology 76 (3 …, 1997 | 238 | 1997 |
Albumin Modified With Mannose 6–Phosphate: A Potential Carrier for Selective Delivery of Antifibrotic Drugs to Rat and Human Hepatic Stellate Cells L Beljaars, G Molema, B Weert, H Bonnema, P Olinga, GM Groothuis, ... Hepatology 29 (5), 1486-1493, 1999 | 224 | 1999 |
Role of alkaline phosphatase in colitis in man and rats A Tuin, K Poelstra, A de Jager-Krikken, L Bok, W Raaben, MP Velders, ... Gut 58 (3), 379-387, 2009 | 208 | 2009 |
Tauroursodeoxycholic acid protects rat hepatocytes from bile acid‐induced apoptosis via activation of survival pathways MH Schoemaker, L Conde de la Rosa, M Buist‐Homan, TE Vrenken, ... Hepatology 39 (6), 1563-1573, 2004 | 204 | 2004 |
Drug targeting to the diseased liver K Poelstra, J Prakash, L Beljaars Journal of controlled release 161 (2), 188-197, 2012 | 200 | 2012 |
The effect of parenterally administered cyclodextrins on cholesterol levels in the rat HW Frijlink, AC Eissens, NR Hefting, K Poelstra, CF Lerk, DKF Meijer Pharmaceutical research 8, 9-16, 1991 | 200 | 1991 |
Successful targeting to rat hepatic stellate cells using albumin modified with cyclic peptides that recognize the collagen type VI receptor L Beljaars, G Molema, D Schuppan, A Geerts, PJ De Bleser, B Weert, ... Journal of Biological Chemistry 275 (17), 12743-12751, 2000 | 198 | 2000 |
Reduction of advanced liver fibrosis by short‐term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats M Moreno, T Gonzalo, RJ Kok, P Sancho‐Bru, M Van Beuge, J Swart, ... Hepatology 51 (3), 942-952, 2010 | 173 | 2010 |
Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation MH Schoemaker, WM Gommans, LC de la Rosa, M Homan, P Klok, ... Journal of hepatology 39 (2), 153-161, 2003 | 165 | 2003 |
Targeting dexamethasone to Kupffer cells: effects on liver inflammation and fibrosis in rats BN Melgert, P Olinga, JMS Van Der Laan, B Weert, J Cho, D Schuppan, ... Hepatology 34 (4), 719-728, 2001 | 148 | 2001 |
The role of apolipoprotein E in the elimination of liposomes from blood by hepatocytes in the mouse X Yan, F Kuipers, LM Havekes, R Havinga, B Dontje, K Poelstra, ... Biochemical and biophysical research communications 328 (1), 57-62, 2005 | 146 | 2005 |
The preferential homing of a platelet derived growth factor receptor-recognizing macromolecule to fibroblast-like cells in fibrotic tissue L Beljaars, B Weert, A Geerts, DKF Meijer, K Poelstra Biochemical pharmacology 66 (7), 1307-1317, 2003 | 145 | 2003 |
On the role and fate of LPS-dephosphorylating activity in the rat liver A Tuin, A Huizinga-Van der Vlag, AMMA van Loenen-Weemaes, ... American Journal of Physiology-Gastrointestinal and Liver Physiology 290 (2 …, 2006 | 137 | 2006 |
Novel engineered targeted interferon‐gamma blocks hepatic fibrogenesis in mice R Bansal, J Prakash, E Post, L Beljaars, D Schuppan, K Poelstra Hepatology 54 (2), 586-596, 2011 | 125 | 2011 |
Rat liver slices as a tool to study LPS-induced inflammatory response in the liver P Olinga, MT Merema, MH De Jager, F Derks, BN Melgert, H Moshage, ... Journal of hepatology 35 (2), 187-194, 2001 | 123 | 2001 |
Targeting hepatic stellate cells for cell-specific treatment of liver fibrosis L Beljaars, DK Meijer, K Poelstra Front Biosci 7 (1), e214-e222, 2002 | 120 | 2002 |
HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects S Klein, MM Van Beuge, M Granzow, L Beljaars, R Schierwagen, S Kilic, ... Journal of hepatology 57 (6), 1220-1227, 2012 | 112 | 2012 |