Asymmetric supramolecular primary amine catalysis in aqueous buffer: connections of selective recognition and asymmetric catalysis S Hu, J Li, J Xiang, J Pan, S Luo, JP Cheng Journal of the American Chemical Society 132 (20), 7216-7228, 2010 | 123 | 2010 |
Extremely elevated room-temperature kinetic isotope effects quantify the critical role of barrier width in enzymatic C–H activation S Hu, SC Sharma, AD Scouras, AV Soudackov, CAM Carr, ... Journal of the American Chemical Society 136 (23), 8157-8160, 2014 | 96 | 2014 |
Chiral Amine Thiourea-Promoted Enantioselective Michael Addition Reactions of 3-Substituted Benzofuran-2(3H)-ones to Maleimides X Li, S Hu, Z Xi, L Zhang, S Luo, JP Cheng The Journal of Organic Chemistry 75 (24), 8697-8700, 2010 | 78 | 2010 |
Asymmetric binary-acid catalysis with InBr3 in the inverse-electron-demanding hetero-Diels-Alder reaction of mono-and bis-substituted cyclopentadienes: remote fluoro-effect on … J Lv, L Zhang, S Hu, JP Cheng, S Luo Chemistry (Weinheim an der Bergstrasse, Germany) 18 (3), 799-803, 2011 | 73 | 2011 |
Origins of enzyme catalysis: Experimental findings for C–H activation, new models, and their relevance to prevailing theoretical constructs JP Klinman, AR Offenbacher, S Hu Journal of the American Chemical Society 139 (51), 18409-18427, 2017 | 70 | 2017 |
Hydrogen–deuterium exchange of lipoxygenase uncovers a relationship between distal, solvent exposed protein motions and the thermal activation barrier for catalytic proton … AR Offenbacher, S Hu, EM Poss, CAM Carr, AD Scouras, DM Prigozhin, ... ACS central science 3 (6), 570-579, 2017 | 65 | 2017 |
Enhanced rigidification within a double mutant of soybean lipoxygenase provides experimental support for vibronically nonadiabatic proton-coupled electron transfer models S Hu, AV Soudackov, S Hammes-Schiffer, JP Klinman ACS catalysis 7 (5), 3569-3574, 2017 | 57 | 2017 |
Chiral Primary Amine Catalyzed Asymmetric Direct Cross‐Aldol Reaction of Acetaldehyde S Hu, L Zhang, J Li, S Luo, JP Cheng European Journal of Organic Chemistry 2011 (18), 3347-3352, 2011 | 39 | 2011 |
Chiral amine–polyoxometalate hybrids as recoverable asymmetric enamine catalysts under neat and aqueous conditions J Li, S Hu, S Luo, JP Cheng European Journal of Organic Chemistry 2009 (1), 132-140, 2009 | 34 | 2009 |
Biophysical characterization of a disabled double mutant of soybean lipoxygenase: the “undoing” of precise substrate positioning relative to metal cofactor and an identified … S Hu, AR Offenbacher, EM Thompson, CL Gee, J Wilcoxen, CAM Carr, ... Journal of the American Chemical Society 141 (4), 1555-1567, 2019 | 27 | 2019 |
Temporal and spatial resolution of distal protein motions that activate hydrogen tunneling in soybean lipoxygenase JPT Zaragoza, AR Offenbacher, S Hu, CL Gee, ZM Firestein, N Minnetian, ... Proceedings of the National Academy of Sciences 120 (10), e2211630120, 2023 | 22 | 2023 |
Hydrostatic Pressure Studies Distinguish Global from Local Protein Motions in C− H Activation by Soybean Lipoxygenase‐1 S Hu, J Cattin‐Ortolá, JW Munos, JP Klinman Angewandte Chemie International Edition 55 (32), 9361-9364, 2016 | 18 | 2016 |
AM; Hammes-Schiffer, S.; Alber, T.; Klinman, JP S Hu, SC Sharma, AD Scouras, AV Soudackov, C Carr J. Am. Chem. Soc 136, 8157-8160, 2014 | 18 | 2014 |
Comparative kinetic isotope effects on first-and second-order rate constants of soybean lipoxygenase variants uncover a substrate-binding network S Hu, AR Offenbacher, ED Lu, JP Klinman Journal of Biological Chemistry 294 (48), 18069-18076, 2019 | 10 | 2019 |
Characterization and Phase 1 trial of a B cell activating anti-CD73 antibody for the immunotherapy of COVID-19 SB Willingham, G Criner, C Hill, S Hu, JA Rudnick, B Daine-Matsuoka, ... MedRxiv, 2020.09. 10.20191486, 2020 | 8 | 2020 |
Anti-CD73 antibody activates human B cells, enhances humoral responses and induces redistribution of B cells in patients with cancer RA Miller, JJ Luke, S Hu, S Mahabhashyam, WB Jones, T Marron, ... Journal for Immunotherapy of Cancer 10 (12), 2022 | 7 | 2022 |
Temporal and spatial resolution of a protein quake that activates hydrogen tunneling in soybean lipoxygenase JPT Zaragoza, AR Offenbacher, S Hu, CL Gee, ZM Firestein, N Minnetian, ... bioRxiv, 2022.03. 31.486235, 2022 | 4 | 2022 |
Clinical results with a B cell activating Anti-CD73 antibody for the immunotherapy of COVID-19 RA Miller, P Guru, P Bauer, J Robles, C Tomaszewski, JS Overcash, ... MedRxiv, 2021.09. 13.21263406, 2021 | 4 | 2021 |
701 Activating CD73 on B cells as a target for immunotherapy of COVID-19 and viral associated cancers: clinical activity in human papilloma virus positive (HPV) head and neck … J Luke, J Merchan, B Hughes, J Sosman, A Tripathi, I Puzanov, T Marron, ... Journal for ImmunoTherapy of Cancer 9 (Suppl 2), 2021 | 3 | 2021 |
325 Immunotherapy with B cell activating antibody CPI-006 in patients (pts) with mild to moderate COVID-19 stimulates anti-SARS-CoV-2 antibody response, memory B cells and … G Criner, M Mobasher, C Hill, S Hu, S Mahabhashyam, J Brody, T Marron, ... Journal for ImmunoTherapy of Cancer 8 (Suppl 3), 2020 | 1 | 2020 |