New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties T Etrych, M Jelı́nková, B Řı́hová, K Ulbrich Journal of Controlled Release 73 (1), 89-102, 2001 | 425 | 2001 |
In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity GM Lynn, R Laga, PA Darrah, AS Ishizuka, AJ Balaci, AE Dulcey, ... Nature biotechnology 33 (11), 1201-1210, 2015 | 420 | 2015 |
Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin M Talelli, M Iman, AK Varkouhi, CJF Rijcken, RM Schiffelers, T Etrych, ... Biomaterials 31 (30), 7797-7804, 2010 | 293 | 2010 |
HPMA copolymers with pH-controlled release of doxorubicin: in vitro cytotoxicity and in vivo antitumor activity K Ulbrich, T Etrych, P Chytil, M Jelınková, B Řı́hová Journal of Controlled Release 87 (1-3), 33-47, 2003 | 258 | 2003 |
Biodegradable star HPMA polymer–drug conjugates: Biodegradability, distribution and anti-tumor efficacy T Etrych, L Kovář, J Strohalm, P Chytil, B Říhová, K Ulbrich Journal of Controlled Release 154 (3), 241-248, 2011 | 199 | 2011 |
New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting P Chytil, T Etrych, Č Koňák, M Šírová, T Mrkvan, J Bouček, B Říhová, ... Journal of Controlled Release 127 (2), 121-130, 2008 | 167 | 2008 |
Synthesis of HPMA copolymers containing doxorubicin bound via a hydrazone linkage. Effect of spacer on drug release and in vitro cytotoxicity T Etrych, P Chytil, M Jelínková, B Říhová, K Ulbrich Macromolecular bioscience 2 (1), 43-52, 2002 | 167 | 2002 |
Antibody-targeted polymer–doxorubicin conjugates with pH-controlled activation K Ulbrich, T Etrych, P Chytil, M Jelínková, B Říhová Journal of drug targeting 12 (8), 477-489, 2004 | 155 | 2004 |
HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release T Etrych, M Šírová, L Starovoytova, B Říhová, K Ulbrich Molecular pharmaceutics 7 (4), 1015-1026, 2010 | 152 | 2010 |
Polymer‐coated polyethylenimine/DNA complexes designed for triggered activation by intracellular reduction RC Carlisle, T Etrych, SS Briggs, JA Preece, K Ulbrich, LW Seymour The Journal of Gene Medicine: A cross‐disciplinary journal for research on …, 2004 | 152 | 2004 |
Nanomedicines for inflammatory arthritis: head-to-head comparison of glucocorticoid-containing polymers, micelles, and liposomes L Quan, Y Zhang, BJ Crielaard, A Dusad, SM Lele, CJF Rijcken, ... ACS nano 8 (1), 458-466, 2014 | 151 | 2014 |
Effect of physicochemical modification on the biodistribution and tumor accumulation of HPMA copolymers T Lammers, R Kühnlein, M Kissel, V Subr, T Etrych, R Pola, M Pechar, ... Journal of controlled release 110 (1), 103-118, 2005 | 148 | 2005 |
Intrinsically active nanobody-modified polymeric micelles for tumor-targeted combination therapy M Talelli, S Oliveira, CJF Rijcken, EHE Pieters, T Etrych, K Ulbrich, ... Biomaterials 34 (4), 1255-1260, 2013 | 145 | 2013 |
Fluorescence optical imaging in anticancer drug delivery T Etrych, H Lucas, O Janoušková, P Chytil, T Mueller, K Mäder Journal of Controlled Release 226, 168-181, 2016 | 143 | 2016 |
HPMA copolymer-doxorubicin conjugates: The effects of molecular weight and architecture on biodistribution and in vivo activity T Etrych, V Šubr, J Strohalm, M Šírová, B Říhová, K Ulbrich Journal of controlled release 164 (3), 346-354, 2012 | 143 | 2012 |
N-(2-Hydroxypropyl) methacrylamide-based polymer conjugates with pH-controlled activation of doxorubicin for cell-specific or passive tumour targeting. Synthesis by RAFT … P Chytil, T Etrych, J Kříž, V Šubr, K Ulbrich European journal of pharmaceutical sciences 41 (3-4), 473-482, 2010 | 143 | 2010 |
Doxorubicin bound to a HPMA copolymer carrier through hydrazone bond is effective also in a cancer cell line with a limited content of lysosomes B Rıhová, T Etrych, M Pechar, M Jelınková, M Štastný, O Hovorka, ... Journal of controlled release 74 (1-3), 225-232, 2001 | 139 | 2001 |
Noninvasive optical imaging of nanomedicine biodistribution S Kunjachan, F Gremse, B Theek, P Koczera, R Pola, M Pechar, T Etrych, ... ACS nano 7 (1), 252-262, 2013 | 134 | 2013 |
N‐(2‐hydroxypropyl)methacrylamide‐based polymer conjugates with pH‐controlled activation of doxorubicin. I. New synthesis, physicochemical characterization … T Etrych, T Mrkvan, P Chytil, Č Koňák, B Říhová, K Ulbrich Journal of Applied Polymer Science 109 (5), 3050-3061, 2008 | 122 | 2008 |
Conjugates of doxorubicin with graft HPMA copolymers for passive tumor targeting T Etrych, P Chytil, T Mrkvan, M Šírová, B Říhová, K Ulbrich Journal of Controlled Release 132 (3), 184-192, 2008 | 120 | 2008 |