Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction MD Michael, RN Kulkarni, C Postic, SF Previs, GI Shulman, ... Molecular cell 6 (1), 87-97, 2000 | 1613 | 2000 |
Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes RN Kulkarni, JC Brüning, JN Winnay, C Postic, MA Magnuson, CR Kahn Cell 96 (3), 329-339, 1999 | 1507 | 1999 |
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic β cell-specific gene knock-outs using Cre recombinase C Postic, M Shiota, KD Niswender, TL Jetton, Y Chen, JM Moates, ... Journal of Biological Chemistry 274 (1), 305-315, 1999 | 1485 | 1999 |
Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice C Postic, J Girard The Journal of clinical investigation 118 (3), 829-838, 2008 | 1467 | 2008 |
Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD A Montagner, A Polizzi, E Fouché, S Ducheix, Y Lippi, F Lasserre, ... Gut 65 (7), 1202-1214, 2016 | 632 | 2016 |
Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women L Hoyles, JM Fernández-Real, M Federici, M Serino, J Abbott, ... Nature medicine 24 (7), 1070-1080, 2018 | 594 | 2018 |
Role of the liver in the control of carbohydrate and lipid homeostasis C Postic, R Dentin, J Girard Diabetes & metabolism 30 (5), 398-408, 2004 | 559 | 2004 |
Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice R Dentin, F Benhamed, I Hainault, V Fauveau, F Foufelle, JRB Dyck, ... Diabetes 55 (8), 2159-2170, 2006 | 538 | 2006 |
Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression R Dentin, JP Pégorier, F Benhamed, F Foufelle, P Ferré, V Fauveau, ... Journal of Biological Chemistry 279 (19), 20314-20326, 2004 | 532 | 2004 |
DNA excision in liver by an albumin‐Cre transgene occurs progressively with age C Postic, MA Magnuson genesis 26 (2), 149-150, 2000 | 427 | 2000 |
The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans F Benhamed, PD Denechaud, M Lemoine, C Robichon, M Moldes, ... The Journal of clinical investigation 122 (6), 2176-2194, 2012 | 426 | 2012 |
Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid … R Dentin, J Girard, C Postic Biochimie 87 (1), 81-86, 2005 | 421 | 2005 |
Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation R Dentin, F Benhamed, JP Pégorier, F Foufelle, B Viollet, S Vaulont, ... The Journal of clinical investigation 115 (10), 2843-2854, 2005 | 399 | 2005 |
Brain glucagon-like peptide–1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage C Knauf, PD Cani, C Perrin, MA Iglesias, JF Maury, E Bernard, ... The Journal of clinical investigation 115 (12), 3554-3563, 2005 | 383 | 2005 |
The role of the lipogenic pathway in the development of hepatic steatosis C Postic, J Girard Diabetes & metabolism 34 (6), 643-648, 2008 | 339 | 2008 |
Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice J Bricambert, J Miranda, F Benhamed, J Girard, C Postic, R Dentin The Journal of clinical investigation 120 (12), 4316-4331, 2010 | 335 | 2010 |
ChREBP, a transcriptional regulator of glucose and lipid metabolism C Postic, R Dentin, PD Denechaud, J Girard Annu. Rev. Nutr. 27 (1), 179-192, 2007 | 315 | 2007 |
Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism P She, M Shiota, KD Shelton, R Chalkley, C Postic, MA Magnuson Molecular and cellular biology 20 (17), 6508-6517, 2000 | 287 | 2000 |
Hepatocyte-specific mutation establishes retinoid X receptor α as a heterodimeric integrator of multiple physiological processes in the liver YJY Wan, D An, Y Cai, JJ Repa, T Hung-Po Chen, M Flores, C Postic, ... Molecular and cellular biology 20 (12), 4436-4444, 2000 | 270 | 2000 |
ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver PD Denechaud, P Bossard, JMA Lobaccaro, L Millatt, B Staels, J Girard, ... The Journal of clinical investigation 118 (3), 956-964, 2008 | 257 | 2008 |