Molecular Docking and Dynamics Simulation Revealed the Potential Inhibitory Activity of ACEIs Against SARS-CoV-2 Targeting the hACE2 Receptor AA Al-Karmalawy, MA Dahab, AM Metwaly, SS Elhady, EB Elkaeed, ... Frontiers in Chemistry 9, 661230, 2021 | 157 | 2021 |
Design, synthesis and anticancer evaluation of thieno [2, 3-d] pyrimidine derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers SA Elmetwally, KF Saied, IH Eissa, EB Elkaeed Bioorganic chemistry 88, 102944, 2019 | 142 | 2019 |
Design, synthesis, molecular modeling, in vivo studies and anticancer evaluation of quinazolin-4 (3H)-one derivatives as potential VEGFR-2 inhibitors and apoptosis inducers HA Mahdy, MK Ibrahim, AM Metwaly, A Belal, ABM Mehany, ... Bioorganic Chemistry 94, 103422, 2020 | 131 | 2020 |
Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene) thiazolidin-2-ylidene) amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and … WM Eldehna, MF Abo-Ashour, A Nocentini, P Gratteri, IH Eissa, M Fares, ... European journal of medicinal chemistry 139, 250-262, 2017 | 127 | 2017 |
Design, synthesis, molecular docking, and anticancer activity of benzoxazole derivatives as VEGFR‐2 inhibitors AGA El‐Helby, H Sakr, IH Eissa, H Abulkhair, AA Al‐Karmalawy, K El‐Adl Archiv der Pharmazie 352 (10), 1900113, 2019 | 122 | 2019 |
Design, synthesis and anticancer evaluation of 1H-pyrazolo [3, 4-d] pyrimidine derivatives as potent EGFRWT and EGFRT790M inhibitors and apoptosis inducers AA Gaber, AH Bayoumi, AM El-Morsy, FF Sherbiny, ABM Mehany, ... Bioorganic chemistry 80, 375-395, 2018 | 120 | 2018 |
Design, synthesis, molecular modeling and biological evaluation of novel 1H-pyrazolo [3, 4-b] pyridine derivatives as potential anticancer agents IH Eissa, AM El-Naggar, MA El-Hashash Bioorganic chemistry 67, 43-56, 2016 | 120 | 2016 |
Design, synthesis, molecular modeling and anti-proliferative evaluation of novel quinoxaline derivatives as potential DNA intercalators and topoisomerase II inhibitors MK Ibrahim, MS Taghour, AM Metwaly, A Belal, ABM Mehany, ... European journal of medicinal chemistry 155, 117-134, 2018 | 108 | 2018 |
Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFR WT and EGFR T790M AA Nasser, IH Eissa, MR Oun, MA El-Zahabi, MS Taghour, A Belal, ... Organic & biomolecular chemistry 18 (38), 7608-7634, 2020 | 105 | 2020 |
Traditional ancient Egyptian medicine: A review AM Metwaly, MM Ghoneim, IH Eissa, IA Elsehemy, AE Mostafa, ... Saudi journal of biological sciences 28 (10), 5823-5832, 2021 | 104 | 2021 |
New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: Design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in silico studies H Elkady, A Elwan, HA El-Mahdy, AS Doghish, A Ismail, MS Taghour, ... Journal of enzyme inhibition and medicinal chemistry 37 (1), 403-416, 2022 | 103 | 2022 |
Benzoxazole/benzothiazole‐derived VEGFR‐2 inhibitors: design, synthesis, molecular docking, and anticancer evaluations AGA El‐Helby, H Sakr, IH Eissa, AA Al‐Karmalawy, K El‐Adl Archiv Der Pharmazie 352 (12), 1900178, 2019 | 90 | 2019 |
Synthesis, docking, QSAR, ADMET and antimicrobial evaluation of new quinoline-3-carbonitrile derivatives as potential DNA-gyrase inhibitors KM El-Gamal, AM El-Morsy, AM Saad, IH Eissa, M Alswah Journal of Molecular Structure 1166, 15-33, 2018 | 86 | 2018 |
Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of quinazolin-4(3H)-one derivatives as potential PPARγ and SUR agonists MK Ibrahim, IH Eissa, MS Alesawy, AM Metwaly, MM Radwan, ... Bioorganic & medicinal chemistry 25 (17), 4723-4744, 2017 | 86 | 2017 |
Discovery of thieno [2, 3-d] pyrimidine-based derivatives as potent VEGFR-2 kinase inhibitors and anti-cancer agents SA El-Metwally, MM Abou-El-Regal, IH Eissa, ABM Mehany, HA Mahdy, ... Bioorganic Chemistry 112, 104947, 2021 | 85 | 2021 |
Comprehensive virtual screening of the antiviral potentialities of marine polycyclic guanidine alkaloids against SARS-CoV-2 (COVID-19) A El-Demerdash, AM Metwaly, A Hassan, TM Abd El-Aziz, EB Elkaeed, ... Biomolecules 11 (3), 460, 2021 | 82 | 2021 |
Design, synthesis, and biological evaluation of new challenging thalidomide analogs as potential anticancer immunomodulatory agents MA El-Zahabi, H Sakr, K El-Adl, M Zayed, AS Abdelraheem, SI Eissa, ... Bioorganic chemistry 104, 104218, 2020 | 82 | 2020 |
Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of novel quinoxaline derivatives as potential PPARγ and SUR agonists MK Ibrahim, IH Eissa, AE Abdallah, AM Metwaly, MM Radwan, ... Bioorganic & medicinal chemistry 25 (4), 1496-1513, 2017 | 79 | 2017 |
Design, synthesis, docking, DFT, MD simulation studies of a new nicotinamide-based derivative: In vitro anticancer and VEGFR-2 inhibitory effects EB Elkaeed, RG Yousef, H Elkady, IMM Gobaara, BA Alsfouk, DZ Husein, ... Molecules 27 (14), 4606, 2022 | 78 | 2022 |
Design, synthesis, molecular docking and anticancer evaluations of 5-benzylidenethiazolidine-2, 4-dione derivatives targeting VEGFR-2 enzyme K El-Adl, AGA El-Helby, H Sakr, IH Eissa, SSA El-Hddad, FMIA Shoman Bioorganic chemistry 102, 104059, 2020 | 77 | 2020 |