Supersaturating drug delivery systems: the answer to solubility-limited oral bioavailability? J Brouwers, ME Brewster, P Augustijns Journal of pharmaceutical sciences 98 (8), 2549-2572, 2009 | 1026 | 2009 |
In vitro models for the prediction of in vivo performance of oral dosage forms ES Kostewicz, B Abrahamsson, M Brewster, J Brouwers, J Butler, ... European Journal of Pharmaceutical Sciences 57, 342-366, 2014 | 404 | 2014 |
Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems BJ Boyd, CAS Bergström, Z Vinarov, M Kuentz, J Brouwers, P Augustijns, ... European Journal of Pharmaceutical Sciences 137, 104967, 2019 | 303 | 2019 |
In vivo methods for drug absorption–comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient … E Sjögren, B Abrahamsson, P Augustijns, D Becker, MB Bolger, ... European Journal of Pharmaceutical Sciences 57, 99-151, 2014 | 299 | 2014 |
Evaluation of gastrointestinal drug supersaturation and precipitation: strategies and issues J Bevernage, J Brouwers, ME Brewster, P Augustijns International journal of pharmaceutics 453 (1), 25-35, 2013 | 277 | 2013 |
Characterization of human duodenal fluids in fasted and fed state conditions D Riethorst, R Mols, G Duchateau, J Tack, J Brouwers, P Augustijns Journal of pharmaceutical sciences 105 (2), 673-681, 2016 | 237 | 2016 |
A review of drug solubility in human intestinal fluids: implications for the prediction of oral absorption P Augustijns, B Wuyts, B Hens, P Annaert, J Butler, J Brouwers European Journal of Pharmaceutical Sciences 57, 322-332, 2014 | 203 | 2014 |
Drug permeability profiling using cell-free permeation tools: Overview and applications P Berben, A Bauer-Brandl, M Brandl, B Faller, GE Flaten, AC Jacobsen, ... European Journal of Pharmaceutical Sciences 119, 219-233, 2018 | 198 | 2018 |
Excipient-mediated supersaturation stabilization in human intestinal fluids J Bevernage, T Forier, J Brouwers, J Tack, P Annaert, P Augustijns Molecular pharmaceutics 8 (2), 564-570, 2011 | 164 | 2011 |
Effect of pH and comedication on gastrointestinal absorption of posaconazole: monitoring of intraluminal and plasma drug concentrations J Walravens, J Brouwers, I Spriet, J Tack, P Annaert, P Augustijns Clinical pharmacokinetics 50, 725-734, 2011 | 146 | 2011 |
Intestinal drug solubility estimation based on simulated intestinal fluids: comparison with solubility in human intestinal fluids S Clarysse, J Brouwers, J Tack, P Annaert, P Augustijns European Journal of Pharmaceutical Sciences 43 (4), 260-269, 2011 | 138 | 2011 |
Drug precipitation–permeation interplay: supersaturation in an absorptive environment J Bevernage, J Brouwers, P Annaert, P Augustijns European journal of pharmaceutics and biopharmaceutics 82 (2), 424-428, 2012 | 136 | 2012 |
Postprandial changes in solubilizing capacity of human intestinal fluids for BCS class II drugs S Clarysse, D Psachoulias, J Brouwers, J Tack, P Annaert, G Duchateau, ... Pharmaceutical research 26, 1456-1466, 2009 | 135 | 2009 |
In vitro models for the prediction of in vivo performance of oral dosage forms: recent progress from partnership through the IMI OrBiTo collaboration J Butler, B Hens, M Vertzoni, J Brouwers, P Berben, J Dressman, ... European Journal of Pharmaceutics and Biopharmaceutics 136, 70-83, 2019 | 121 | 2019 |
Supersaturation and precipitation of posaconazole upon entry in the upper small intestine in humans B Hens, J Brouwers, M Corsetti, P Augustijns Journal of pharmaceutical sciences 105 (9), 2677-2684, 2016 | 121 | 2016 |
Intraluminal drug and formulation behavior and integration in in vitro permeability estimation: a case study with amprenavir J Brouwers, J Tack, F Lammert, P Augustijns Journal of pharmaceutical sciences 95 (2), 372-383, 2006 | 117 | 2006 |
Drug supersaturation in simulated human intestinal fluids representing different nutritional states J Bevernage, J Brouwers, S Clarysse, M Vertzoni, JAN Tack, P Annaert, ... Journal of pharmaceutical sciences 99 (11), 4525-4534, 2010 | 112 | 2010 |
Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities B Hens, M Corsetti, R Spiller, L Marciani, T Vanuytsel, J Tack, A Talattof, ... International Journal of Pharmaceutics 519 (1-2), 79-97, 2017 | 107 | 2017 |
Food-dependent disintegration of immediate release fosamprenavir tablets: in vitro evaluation using magnetic resonance imaging and a dynamic gastrointestinal system J Brouwers, B Anneveld, GJ Goudappel, G Duchateau, P Annaert, ... European Journal of Pharmaceutics and Biopharmaceutics 77 (2), 313-319, 2011 | 106 | 2011 |
The dynamic gastric environment and its impact on drug and formulation behaviour J Van den Abeele, J Rubbens, J Brouwers, P Augustijns European Journal of Pharmaceutical Sciences 96, 207-231, 2017 | 99 | 2017 |