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Field-deployable viral diagnostics using CRISPR-Cas13 C Myhrvold*, CA Freije*, JS Gootenberg, OO Abudayyeh, HC Metsky, ... Science 360 (6387), 444-448, 2018 | 1191 | 2018 |
Massively multiplexed nucleic acid detection with Cas13 CM Ackerman*, C Myhrvold*, SG Thakku+, CA Freije+, HC Metsky, ... Nature 582 (7811), 277-282, 2020 | 626 | 2020 |
Zika virus evolution and spread in the Americas HC Metsky*, CB Matranga*, S Wohl*, SF Schaffner*, CA Freije, ... Nature 546 (7658), 411-415, 2017 | 436 | 2017 |
Streamlined inactivation, amplification, and Cas13-based detection of SARS-CoV-2 J Arizti-Sanz*, CA Freije*, AC Stanton, BA Petros, CK Boehm, S Siddiqui, ... Nature communications 11 (1), 1-9, 2020 | 380* | 2020 |
Genomic epidemiology reveals multiple introductions of Zika virus into the United States ND Grubaugh, JT Ladner, MUG Kraemer, G Dudas, AL Tan, ... Nature 546 (7658), 401-405, 2017 | 372 | 2017 |
Programmable inhibition and detection of RNA viruses using Cas13 CA Freije*, C Myhrvold*, CK Boehm, AE Lin, NL Welch, A Carter, ... Molecular cell 76 (5), 826-837. e11, 2019 | 371 | 2019 |
Genomic analysis of Lassa virus during an increase in cases in Nigeria in 2018 KJ Siddle, P Eromon, KG Barnes, S Mehta, JU Oguzie, I Odia, ... New England Journal of Medicine 379 (18), 1745-1753, 2018 | 185 | 2018 |
Deployable CRISPR-Cas13a diagnostic tools to detect and report Ebola and Lassa virus cases in real-time KG Barnes*, AE Lachenauer*, A Nitido, S Siddiqui, R Gross, B Beitzel, ... Nature communications 11 (1), 1-10, 2020 | 143 | 2020 |
Transcriptomic characterization of fibrolamellar hepatocellular carcinoma EP Simon, CA Freije, BA Farber, G Lalazar, DG Darcy, JN Honeyman, ... Proceedings of the National Academy of Sciences 112 (44), E5916-E5925, 2015 | 122 | 2015 |
Simplified Cas13-based assays for the fast identification of SARS-CoV-2 and its variants J Arizti-Sanz, AD Bradley, YB Zhang, CK Boehm, CA Freije, ME Grunberg, ... Nature Biomedical Engineering 6 (8), 932-943, 2022 | 115* | 2022 |
Inborn errors of RNA lariat metabolism in humans with brainstem viral infection SY Zhang, NE Clark+, CA Freije+, E Pauwels, AJ Taggart, S Okada, ... Cell 172 (5), 952-965. e18, 2018 | 113 | 2018 |
Detect and destroy: CRISPR-based technologies for the response against viruses CA Freije, PC Sabeti Cell host & microbe 29 (5), 689-703, 2021 | 65 | 2021 |
CRISPR-based COVID-19 surveillance using a genomically-comprehensive machine learning approach HC Metsky, CA Freije, TSF Kosoko-Thoroddsen, PC Sabeti, C Myhrvold BioRxiv, 2020.02. 26.967026, 2020 | 58 | 2020 |
Longitudinal transcriptomic characterization of the immune response to acute hepatitis C virus infection in patients with spontaneous viral clearance BR Rosenberg, M Depla, CA Freije, D Gaucher, S Mazouz, M Boisvert, ... PLoS pathogens 14 (9), e1007290, 2018 | 39 | 2018 |
Powassan virus neuropathology and genomic diversity in patients with fatal encephalitis E Normandin, IH Solomon, S Zamirpour, J Lemieux, CA Freije, SS Mukerji, ... Open Forum Infectious Diseases 7 (10), ofaa392, 2020 | 27 | 2020 |
Genetic Variation at IFNL4 Influences Extrahepatic Interferon-Stimulated Gene Expression in Chronic HCV Patients BR Rosenberg, CA Freije, N Imanaka, ST Chen, JL Eitson, R Caron, ... The Journal of infectious diseases 217 (4), 650-655, 2018 | 23 | 2018 |
Crispr system based antiviral therapy F Zhang, JS Gootenberg, OO Abudayyeh, P Sabeti, C Myhrvold, CA Freije US Patent App. 16/629,310, 2020 | 13 | 2020 |
Metagenomic sequencing of HIV-1 in the blood and female genital tract reveals little quasispecies diversity during acute infection A Piantadosi, CA Freije, C Gosmann, S Ye, D Park, SF Schaffner, ... Journal of virology 93 (2), 2019 | 12 | 2019 |
Crispr effector system based diagnostics for virus detection O Abudayyeh, J Gootenberg, ES Lander, P SABETI, CA FREIJE, ... | 6 | 2020 |