Gene body methylation can alter gene expression and is a therapeutic target in cancer X Yang, H Han, DD De Carvalho, FD Lay, PA Jones, G Liang Cancer cell 26 (4), 577-590, 2014 | 1149 | 2014 |
Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules TK Kelly, Y Liu, FD Lay, G Liang, BP Berman, PA Jones Genome research 22 (12), 2497-2506, 2012 | 464 | 2012 |
Targeting DNA methylation for epigenetic therapy X Yang, F Lay, H Han, PA Jones Trends in pharmacological sciences 31 (11), 536-546, 2010 | 386 | 2010 |
MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment V Calvanese, AT Nguyen, TJ Bolan, A Vavilina, T Su, LK Lee, Y Wang, ... Nature 576 (7786), 281-286, 2019 | 123 | 2019 |
Bivalent regions of cytosine methylation and H3K27 acetylation suggest an active role for DNA methylation at enhancers J Charlet, CE Duymich, FD Lay, K Mundbjerg, KD Sørensen, G Liang, ... Molecular cell 62 (3), 422-431, 2016 | 120 | 2016 |
A high-resolution 3D epigenomic map reveals insights into the creation of the prostate cancer transcriptome SK Rhie, AA Perez, FD Lay, S Schreiner, J Shi, J Polin, PJ Farnham Nature communications 10 (1), 4154, 2019 | 109 | 2019 |
The role of DNA methylation in directing the functional organization of the cancer epigenome FD Lay, Y Liu, TK Kelly, H Witt, PJ Farnham, PA Jones, BP Berman Genome research 25 (4), 467-477, 2015 | 104 | 2015 |
Promoter-enhancer communication occurs primarily within insulated neighborhoods F Sun, C Chronis, M Kronenberg, XF Chen, T Su, FD Lay, K Plath, ... Molecular cell 73 (2), 250-263. e5, 2019 | 89 | 2019 |
Genetic regulation of fibroblast activation and proliferation in cardiac fibrosis S Park, S Ranjbarvaziri, FD Lay, P Zhao, MJ Miller, JS Dhaliwal, ... Circulation 138 (12), 1224-1235, 2018 | 73 | 2018 |
A prostate cancer risk element functions as a repressive loop that regulates HOXA13 Z Luo, SK Rhie, FD Lay, PJ Farnham Cell reports 21 (6), 1411-1417, 2017 | 70 | 2017 |
Cbx3 maintains lineage specificity during neural differentiation C Huang, T Su, Y Xue, C Cheng, FD Lay, RA McKee, M Li, A Vashisht, ... Genes & Development 31 (3), 241-246, 2017 | 46 | 2017 |
Using 3D epigenomic maps of primary olfactory neuronal cells from living individuals to understand gene regulation SK Rhie, S Schreiner, H Witt, C Armoskus, FD Lay, A Camarena, ... Science advances 4 (12), eaav8550, 2018 | 45 | 2018 |
Short-term correction of arginase deficiency in a neonatal murine model with a helper-dependent adenoviral vector CL Gau, RA Rosenblatt, V Cerullo, FD Lay, AC Dow, J Livesay, ... Molecular Therapy 17 (7), 1155-1163, 2009 | 36 | 2009 |
Nucleosome occupancy and methylome sequencing (NOMe-seq) FD Lay, TK Kelly, PA Jones DNA Methylation Protocols, 267-284, 2018 | 34 | 2018 |
Nucleosome positioning and NDR structure at RNA polymerase III promoters AS Helbo, FD Lay, PA Jones, G Liang, K Grønbæk Scientific reports 7 (1), 41947, 2017 | 34 | 2017 |
FGFR2 mutations in bent bone dysplasia syndrome activate nucleolar stress and perturb cell fate determination CL Neben, CT Tuzon, X Mao, FD Lay, AE Merrill Human Molecular Genetics 26 (17), 3253-3270, 2017 | 17 | 2017 |
Ribosome biogenesis is dynamically regulated during osteoblast differentiation CL Neben, FD Lay, X Mao, CT Tuzon, AE Merrill Gene 612, 29-35, 2017 | 17 | 2017 |
Reprogramming of the human intestinal epigenome by surgical tissue transposition FD Lay, TJ Triche, YC Tsai, SF Su, SE Martin, S Daneshmand, ... Genome research 24 (4), 545-553, 2014 | 16 | 2014 |
Rethinking demethylating agents in epigenetic cancer therapy FD Lay, G Liang J Mol Pharm Org Process Res 4 (133), 2, 2016 | 9 | 2016 |
Multi-omic characterization of antibody-producing CHO cell lines elucidates metabolic reprogramming and nutrient uptake bottlenecks S Gopalakrishnan, W Johnson, MAV Gomez, E Icten, J Tat, F Lay, J Diep, ... bioRxiv, 2023.09. 13.557626, 2023 | 1 | 2023 |