| Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy RD Sentelle, CE Senkal, W Jiang, S Ponnusamy, S Gencer, ... Nature chemical biology 8 (10), 831-838, 2012 | 548 | 2012 |
| Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance S Ponnusamy, M Meyers-Needham, CE Senkal, SA Saddoughi, ... Future oncology 6 (10), 1603-1624, 2010 | 374 | 2010 |
| Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways CE Senkal, S Ponnusamy, J Bielawski, YA Hannun, B Ogretmen The FASEB Journal 24 (1), 296, 2010 | 282 | 2010 |
| Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling A Mukhopadhyay, SA Saddoughi, P Song, I Sultan, S Ponnusamy, ... The FASEB Journal 23 (3), 751, 2009 | 260 | 2009 |
| Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas CE Senkal, S Ponnusamy, MJ Rossi, J Bialewski, D Sinha, JC Jiang, ... Molecular cancer therapeutics 6 (2), 712-722, 2007 | 199 | 2007 |
| Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1‐phosphate signalling to regulate tumour metastasis S Ponnusamy, SP Selvam, S Mehrotra, T Kawamori, AJ Snider, LM Obeid, ... EMBO molecular medicine 4 (8), 761-775, 2012 | 167 | 2012 |
| Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenase KP Sundararaj, RE Wood, S Ponnusamy, AM Salas, Z Szulc, A Bielawska, ... Journal of Biological Chemistry 279 (7), 6152-6162, 2004 | 161 | 2004 |
| Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A A Salas, S Ponnusamy, CE Senkal, M Meyers-Needham, SP Selvam, ... Blood, The Journal of the American Society of Hematology 117 (22), 5941-5952, 2011 | 152 | 2011 |
| Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation S Panneer Selvam, RM De Palma, JJ Oaks, N Oleinik, YK Peterson, ... Science signaling 8 (381), ra58-ra58, 2015 | 144 | 2015 |
| Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular … CE Senkal, S Ponnusamy, Y Manevich, M Meyers-Needham, ... Journal of Biological Chemistry 286 (49), 42446-42458, 2011 | 134 | 2011 |
| Direct binding of glyceraldehyde 3-phosphate dehydrogenase to telomeric DNA protects telomeres against chemotherapy-induced rapid degradation NA Demarse, S Ponnusamy, EK Spicer, E Apohan, JE Baatz, B Ogretmen, ... Journal of molecular biology 394 (4), 789-803, 2009 | 119 | 2009 |
| Neutral Sphingomyelinase-3 Is a DNA Damage and Nongenotoxic Stress-Regulated Gene That Is Deregulated in Human Malignancies CA Corcoran, Q He, S Ponnusamy, B Ogretmen, Y Huang, MS Sheikh Molecular Cancer Research 6 (5), 795-807, 2008 | 103 | 2008 |
| Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo CE Senkal, S Ponnusamy, MJ Rossi, K Sundararaj, Z Szulc, J Bielawski, ... Journal of Pharmacology and Experimental Therapeutics 317 (3), 1188-1199, 2006 | 101 | 2006 |
| Novel selective agents for the degradation of androgen receptor variants to treat castration-resistant prostate cancer S Ponnusamy, CC Coss, T Thiyagarajan, K Watts, DJ Hwang, Y He, ... Cancer Research 77 (22), 6282-6298, 2017 | 87 | 2017 |
| Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function I Sultan, CE Senkal, S Ponnusamy, J Bielawski, Z Szulc, A Bielawska, ... Biochemical Journal 393 (2), 513-521, 2006 | 71 | 2006 |
| Concerted functions of HDAC1 and microRNA‐574‐5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells M Meyers‐Needham, S Ponnusamy, S Gencer, W Jiang, RJ Thomas, ... EMBO molecular medicine 4 (2), 78-92, 2012 | 67 | 2012 |
| Pharmacologic activation of estrogen receptor β increases mitochondrial function, energy expenditure, and brown adipose tissue S Ponnusamy, QT Tran, I Harvey, HS Smallwood, T Thiyagarajan, ... The FASEB Journal 31 (1), 266, 2017 | 63 | 2017 |
| Orally bioavailable androgen receptor degrader, potential next-generation therapeutic for enzalutamide-resistant prostate cancer S Ponnusamy, Y He, DJ Hwang, T Thiyagarajan, R Houtman, ... Clinical Cancer Research 25 (22), 6764-6780, 2019 | 60 | 2019 |
| New generation of selective androgen receptor degraders: our initial design, synthesis, and biological evaluation of new compounds with enzalutamide-resistant prostate cancer … DJ Hwang, Y He, S Ponnusamy, ML Mohler, T Thiyagarajan, IJ McEwan, ... Journal of Medicinal Chemistry 62 (2), 491-511, 2018 | 59 | 2018 |
| An overview of next-generation androgen receptor-targeted therapeutics in development for the treatment of prostate cancer ML Mohler, A Sikdar, S Ponnusamy, DJ Hwang, Y He, DD Miller, ... International journal of molecular sciences 22 (4), 2124, 2021 | 54 | 2021 |
