| An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level DE Bauer, SC Kamran, S Lessard, J Xu, Y Fujiwara, C Lin, Z Shao, ... Science 342 (6155), 253-257, 2013 | 693 | 2013 |
| Human genetic variation alters CRISPR-Cas9 on-and off-targeting specificity at therapeutically implicated loci S Lessard, L Francioli, J Alfoldi, JC Tardif, PT Ellinor, DG MacArthur, ... Proceedings of the National Academy of Sciences 114 (52), E11257-E11266, 2017 | 133 | 2017 |
| Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci MC Canver, S Lessard, L Pinello, Y Wu, Y Ilboudo, EN Stern, ... Nature genetics 49 (4), 625-634, 2017 | 117 | 2017 |
| Frameshift indels introduced by genome editing can lead to in-frame exon skipping S Lalonde, OA Stone, S Lessard, A Lavertu, J Desjardins, M Beaudoin, ... PloS one 12 (6), e0178700, 2017 | 112 | 2017 |
| Exome genotyping identifies pleiotropic variants associated with red blood cell traits N Chami, MH Chen, AJ Slater, JD Eicher, E Evangelou, SM Tajuddin, ... The American Journal of Human Genetics 99 (1), 8-21, 2016 | 72 | 2016 |
| An erythroid-specific ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility S Lessard, ES Gatof, M Beaudoin, PG Schupp, F Sher, A Ali, S Prehar, ... The Journal of clinical investigation 127 (8), 3065-3074, 2017 | 68 | 2017 |
| Common α-globin variants modify hematologic and other clinical phenotypes in sickle cell trait and disease LM Raffield, JC Ulirsch, RP Naik, S Lessard, RE Handsaker, D Jain, ... PLoS genetics 14 (3), e1007293, 2018 | 63 | 2018 |
| Comparison of DNA methylation profiles in human fetal and adult red blood cell progenitors S Lessard, M Beaudoin, K Benkirane, G Lettre Genome Medicine 7, 1, 2015 | 52 | 2015 |
| Genetic risk factors associated with preeclampsia and hypertensive disorders of pregnancy JS Tyrmi, T Kaartokallio, AI Lokki, T Jääskeläinen, E Kortelainen, ... JAMA cardiology 8 (7), 674-683, 2023 | 41 | 2023 |
| 14q32 and let-7 microRNAs regulate transcriptional networks in fetal and adult human erythroblasts S Lessard, M Beaudoin, SH Orkin, DE Bauer, G Lettre Human molecular genetics 27 (8), 1411-1420, 2018 | 37 | 2018 |
| Lower Methylation of the ANGPTL2 Gene in Leukocytes from Post-Acute Coronary Syndrome Patients A Nguyen, M Mamarbachi, V Turcot, S Lessard, C Yu, X Luo, J Lalonge, ... PLoS One 11 (4), e0153920, 2016 | 31 | 2016 |
| The public health impact of poor sleep on severe COVID-19, influenza and upper respiratory infections SE Jones, FI Maisha, SJ Strausz, V Lammi, BE Cade, A Tervi, ... Ebiomedicine 93, 2023 | 14 | 2023 |
| NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Hematology & Hemostasis, Diabetes, and Structural Variation TOPMed Working Groups. Common α-globin variants modify … LM Raffield, JC Ulirsch, RP Naik, S Lessard, RE Handsaker, D Jain, ... PLoS Genet 14 (3), e1007293, 2018 | 14 | 2018 |
| A saturating mutagenesis CRISPR-Cas9–mediated functional genomic screen identifies cis-and trans-regulatory elements of Oct4 in murine ESCs MC Canver, P Tripathi, MJ Bullen, M Olshansky, Y Kumar, LH Wong, ... Journal of Biological Chemistry 295 (47), 15797-15809, 2020 | 11 | 2020 |
| Testing the role of predicted gene knockouts in human anthropometric trait variation S Lessard, AK Manning, C Low-Kam, PL Auer, A Giri, M Graff, ... Human Molecular Genetics 25 (10), 2082-2092, 2016 | 10 | 2016 |
| Comprehensive inherited risk estimation for risk-based breast cancer screening in women N Mars, S Kerminen, M Tamlander, M Pirinen, E Jakkula, K Aaltonen, ... Journal of Clinical Oncology 42 (13), 1477-1487, 2024 | 8 | 2024 |
| Zinc finger nuclease-mediated disruption of the BCL11A erythroid enhancer results in enriched biallelic editing, increased fetal hemoglobin, and reduced sickling in erythroid … S Lessard, P Rimmele, H Ling, K Moran, B Vieira, YD Lin, V Hong, A Reik, ... Blood 134, 974, 2019 | 7 | 2019 |
| Ex vivo gene-edited cell therapy for sickle cell disease: disruption of the BCL11A erythroid enhancer with zinc finger nucleases increases fetal hemoglobin in plerixafor … K Moran, H Ling, S Lessard, B Vieira, V Hong, MC Holmes, A Reik, ... Blood 132, 2190, 2018 | 7 | 2018 |
| Atlas of epistasis C Chatelain, S Lessard, V Thuillier, C Carliez, D Rajpal, F Augé medRxiv, 2021.03. 17.21253794, 2021 | 6 | 2021 |
| Major Genetic Risk Factors for Dupuytren's Disease Are Inherited From Neandertals R Ågren, S Patil, X Zhou, K Sahlholm, S Pääbo, H Zeberg Molecular biology and evolution 40 (6), msad130, 2023 | 4 | 2023 |
