Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer A Carracedo, L Ma, J Teruya-Feldstein, F Rojo, L Salmena, A Alimonti, ... The Journal of clinical investigation 118 (9), 3065-3074, 2008 | 1679 | 2008 |
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses D Anastasiou, G Poulogiannis, JM Asara, MB Boxer, J Jiang, M Shen, ... Science 334 (6060), 1278-1283, 2011 | 1243 | 2011 |
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis JW Locasale, AR Grassian, T Melman, CA Lyssiotis, KR Mattaini, AJ Bass, ... Nature genetics 43 (9), 869-874, 2011 | 1193 | 2011 |
The JAK‐binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop H Yasukawa, H Misawa, H Sakamoto, M Masuhara, A Sasaki, T Wakioka, ... The EMBO journal, 1999 | 982 | 1999 |
R-2HG exhibits anti-tumor activity by targeting FTO/m6A/MYC/CEBPA signaling R Su, L Dong, C Li, S Nachtergaele, M Wunderlich, Y Qing, X Deng, ... Cell 172 (1), 90-105. e23, 2018 | 915 | 2018 |
Negative regulation of cytokine signaling pathways H Yasukawa, A Sasaki, A Yoshimura Annual review of immunology 18 (1), 143-164, 2000 | 766 | 2000 |
Cytokine‐inducible SH2 protein‐3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N‐terminal kinase inhibitory region as well as SH2 domain A Sasaki, H Yasukawa, A Suzuki, S Kamizono, T Syoda, I Kinjyo, ... Genes to Cells 4 (6), 339-351, 1999 | 545 | 1999 |
Spred is a Sprouty-related suppressor of Ras signalling T Wakioka, A Sasaki, R Kato, T Shouda, A Matsumoto, K Miyoshi, ... Nature 412 (6847), 647-651, 2001 | 509 | 2001 |
SOCS3 is essential in the regulation of fetal liver erythropoiesis JC Marine, C McKay, D Wang, DJ Topham, E Parganas, H Nakajima, ... Cell 98 (5), 617-627, 1999 | 484 | 1999 |
CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2 A Sasaki, H Yasukawa, T Shouda, T Kitamura, I Dikic, A Yoshimura Journal of Biological Chemistry 275 (38), 29338-29347, 2000 | 461 | 2000 |
Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement AT Sasaki, C Chun, K Takeda, RA Firtel The Journal of cell biology 167 (3), 505-518, 2004 | 451 | 2004 |
Systemic elevation of PTEN induces a tumor-suppressive metabolic state I Garcia-Cao, MS Song, RM Hobbs, G Laurent, C Giorgi, VCJ De Boer, ... Cell 149 (1), 49-62, 2012 | 439 | 2012 |
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1 A Sasaki, T Taketomi, R Kato, K Saeki, A Nonami, M Sasaki, M Kuriyama, ... Nature cell biology 5 (5), 427-432, 2003 | 355 | 2003 |
SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130 U Lehmann, J Schmitz, M Weissenbach, RM Sobota, M Hortner, ... Journal of Biological Chemistry 278 (1), 661-671, 2003 | 333 | 2003 |
Cloning and characterization of novel CIS family genes M Masuhara, H Sakamoto, A Matsumoto, R Suzuki, H Yasukawa, K Mitsui, ... Biochemical and biophysical research communications 239 (2), 439-446, 1997 | 326 | 1997 |
G protein–independent Ras/PI3K/F-actin circuit regulates basic cell motility AT Sasaki, C Janetopoulos, S Lee, PG Charest, K Takeda, ... The Journal of cell biology 178 (2), 185-191, 2007 | 257 | 2007 |
TOR Complex 2 Integrates Cell Movement during Chemotaxis and Signal Relay in Dictyostelium S Lee, FI Comer, A Sasaki, IX McLeod, Y Duong, K Okumura, JR Yates III, ... Molecular biology of the cell 16 (10), 4572-4583, 2005 | 256 | 2005 |
A Janus Kinase Inhibitor, JAB, Is an Interferon-γ–Inducible Gene and Confers Resistance to Interferons H Sakamoto, H Yasukawa, M Masuhara, S Tanimura, A Sasaki, K Yuge, ... Blood, The Journal of the American Society of Hematology 92 (5), 1668-1676, 1998 | 225 | 1998 |
Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factor-but not epidermal growth factor-induced ERK activation A Sasaki, T Taketomi, T Wakioka, R Kato, A Yoshimura Journal of Biological Chemistry 276 (39), 36804-36808, 2001 | 220 | 2001 |
Mucosal T cells bearing TCRγδ play a protective role in intestinal inflammation K Inagaki-Ohara, T Chinen, G Matsuzaki, A Sasaki, Y Sakamoto, ... The Journal of Immunology 173 (2), 1390-1398, 2004 | 205 | 2004 |