The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity DE Foxler, KS Bridge, V James, TM Webb, M Mee, SCK Wong, Y Feng, ... Nature cell biology 14 (2), 201-208, 2012 | 104 | 2012 |
Argonaute utilization for miRNA silencing is determined by phosphorylation-dependent recruitment of LIM-domain-containing proteins KS Bridge, KM Shah, Y Li, DE Foxler, SCK Wong, DC Miller, KM Davidson, ... Cell reports 20 (1), 173-187, 2017 | 67 | 2017 |
Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences AJ Haider, MH Cox, N Jones, AJ Goode, KS Bridge, K Wong, D Briggs, ... Bioscience reports 35 (4), e00241, 2015 | 31 | 2015 |
S6K2-mediated regulation of TRBP as a determinant of miRNA expression in human primary lymphatic endothelial cells MJ Warner, KS Bridge, JP Hewitson, MR Hodgkinson, A Heyam, ... Nucleic acids research 44 (20), 9942-9955, 2016 | 27 | 2016 |
A HIF–LIMD 1 negative feedback mechanism mitigates the pro‐tumorigenic effects of hypoxia DE Foxler, KS Bridge, JG Foster, P Grevitt, S Curry, KM Shah, ... EMBO molecular medicine 10 (8), e8304, 2018 | 21 | 2018 |
Hematopoietic stem cells retain functional potential and molecular identity in hibernation cultures CA Oedekoven, M Belmonte, D Bode, FK Hamey, MS Shepherd, JLC Che, ... Stem cell reports 16 (6), 1614-1628, 2021 | 17 | 2021 |
Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance-related vascular damage A Maqbool, NT Watt, N Haywood, H Viswambharan, A Skromna, ... American Journal of Physiology-Cell Physiology 319 (1), C64-C74, 2020 | 15 | 2020 |
Markers for human haematopoietic stem cells: The disconnect between an identification marker and its function B Rix, AH Maduro, KS Bridge, W Grey Frontiers in physiology 13, 1009160, 2022 | 12 | 2022 |
Physioxia improves the selectivity of hematopoietic stem cell expansion cultures KJ Igarashi, I Kucinski, YY Chan, TK Tan, HM Khoo, D Kealy, J Bhadury, ... Blood Advances 7 (14), 3366-3377, 2023 | 8 | 2023 |
Regulators of the hypoxic response: a growing family KS Bridge, TV Sharp Future Oncology 8 (5), 491-493, 2012 | 6 | 2012 |
The CKS1/CKS2 proteostasis Axis is crucial to maintain hematopoietic stem cell function W Grey, S Atkinson, B Rix, P Casado, L Ariza-McNaughton, C Hawley, ... Hemasphere 7 (3), e853, 2023 | 3 | 2023 |
Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes K Davidson, P Grevitt, MF Contreras-Gerenas, KS Bridge, M Hermida, ... Cell Death & Disease 12 (11), 1075, 2021 | 3 | 2021 |
ZMIZ1 enhances ERα-dependent expression of E2F2 in breast cancer W Zhao, SF Rose, R Blake, A Godicelj, AE Cullen, J Stenning, L Beevors, ... Journal of molecular endocrinology 73 (1), 2024 | | 2024 |
PU. 1 Eviction at Lymphocyte-Specific Chromatin Domains Mediates Glucocorticoid Response in Acute Lymphoblastic Leukemia D Jing, D Beck, H Cao, F Tian, Y Huang, H Zhao, X Tai, W XU, H Kosasih, ... | | 2024 |
Hypoxia-Inducible Factor-1 activated by PIM1 assembles a non-canonical transcription complex and resultant regulon that drives progression of JAK2V617F myeloproliferative neoplasms D Kealy, R Ellerington, S Bansal, AGX Zeng, JJF Medeiros, KA West, ... bioRxiv, 2024.07. 02.601518, 2024 | | 2024 |
Aberrant Splicing of MBD1 Reshapes the Epigenome to Drive Convergent Myeloerythroid Defects in MDS HTTT Chen, P Joshi, E Tsao, J Xu, S Jahangiri, Y Mo, D Kealy, ... Blood 142, 317, 2023 | | 2023 |
2018–UNRAVELLING THE EFFECTS OF THE JAK2 V617F MUTATION ON HIF-1 FUNCTION AT THE CHROMATIN D Kealy, C Hawley, R Ellerington, B Ferreira, B Drylie, I Hitchcock, ... Experimental Hematology 124, S45, 2023 | | 2023 |
In Breast Cancer ZMIZ1 Co-Regulates E2F2 as Part of the Estrogen Receptor-Mediated Cell-Cycle Response W Zhao, SF Rose, R Blake, A Godicelj, AE Cullen, J Stenning, L Beevors, ... bioRxiv, 789610, 2019 | | 2019 |
A HIF-LIMD1 negative feedback mechanism drives the adaptive response to hypoxia and mitigates pro-tumorigenic hypoxic effects K Bridge, DE Foxler, JG Foster, P Grevitt, S Curry, KM Shah, KM Davidson, ... EMBO Molecular Medicine, 2018 | | 2018 |
Loss of LIM-domain proteins LIMD1, Ajuba and WTIP as a novel molecular mechanism for disease aetiology in clear cell renal cell carcinoma (ccRCC) K Smith, M Sheaff, G Elia, A Clear, G Trevisan, D Foxler, K Bridge, ... European Journal of Cancer 1 (61), S206, 2016 | | 2016 |