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Nigel Scrutton
Nigel Scrutton
Professor of Enzymology, Manchester Institute of Biotechnology (MIB) and School of Chemistry
在 manchester.ac.uk 的电子邮件经过验证 - 首页
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引用次数
引用次数
年份
Redesign of the coenzyme specificity of a dehydrogenase by protein engineering
NS Scrutton, A Berry, RN Perham
Nature 343 (6253), 38-43, 1990
9021990
Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades
FG Mutti, T Knaus, NS Scrutton, M Breuer, NJ Turner
Science 349 (6255), 1525-1529, 2015
4002015
Atomic description of an enzyme reaction dominated by proton tunneling
L Masgrau, A Roujeinikova, LO Johannissen, P Hothi, J Basran, ...
Science 312 (5771), 237-241, 2006
3982006
Biocatalytic reductions and chemical versatility of the old yellow enzyme family of flavoprotein oxidoreductases
HS Toogood, JM Gardiner, NS Scrutton
ChemCatChem 2 (8), 892-914, 2010
3262010
Cation-π bonding and amino-aromatic interactions in the biomolecular recognition of substituted ammonium ligands
NS Scrutton, ARC Raine
Biochemical Journal 319 (1), 1-8, 1996
3121996
Good vibrations in enzyme-catalysed reactions
S Hay, NS Scrutton
Nature chemistry 4 (3), 161-168, 2012
3102012
Enzymatic H-transfer requires vibration-driven extreme tunneling
J Basran, MJ Sutcliffe, NS Scrutton
Biochemistry 38 (10), 3218-3222, 1999
2881999
Covalent attachment of flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) to enzymes: the current state of affairs
M Mewies, WS McIntire, NS Scrutton
Protein Science 7 (1), 7-20, 1998
2701998
Building a global alliance of biofoundries
N Hillson, M Caddick, Y Cai, JA Carrasco, MW Chang, NC Curach, ...
Nature communications 10 (1), 2040, 2019
2682019
Biotransformation of explosives by the old yellow enzyme family of flavoproteins
RE Williams, DA Rathbone, NS Scrutton, NC Bruce
Applied and environmental microbiology 70 (6), 3566-3574, 2004
2302004
Discovery, characterization, engineering, and applications of ene-reductases for industrial biocatalysis
HS Toogood, NS Scrutton
ACS catalysis 8 (4), 3532-3549, 2018
2292018
New cofactor supports α, β-unsaturated acid decarboxylation via 1, 3-dipolar cycloaddition
KAP Payne, MD White, K Fisher, B Khara, SS Bailey, D Parker, ...
Nature 522 (7557), 497-501, 2015
2262015
An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals
P Carbonell, AJ Jervis, CJ Robinson, C Yan, M Dunstan, N Swainston, ...
Communications biology 1 (1), 66, 2018
2212018
What’s in a covalent bond? On the role and formation of covalently bound flavin cofactors
DPHM Heuts, NS Scrutton, WS McIntire, MW Fraaije
The FEBS journal 276 (13), 3405-3427, 2009
2132009
UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis
MD White, KAP Payne, K Fisher, SA Marshall, D Parker, NJW Rattray, ...
Nature 522 (7557), 502-506, 2015
1992015
Better than nature: nicotinamide biomimetics that outperform natural coenzymes
T Knaus, CE Paul, CW Levy, S De Vries, FG Mutti, F Hollmann, ...
Journal of the American Chemical Society 138 (3), 1033-1039, 2016
1772016
A new conceptual framework for enzyme catalysis: Hydrogen tunneling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes
MJ Sutcliffe, NS Scrutton
European Journal of Biochemistry 269 (13), 3096-3102, 2002
1722002
Biodiversity of cytochrome P450 redox systems
KJ McLean, M Sabri, KR Marshall, RJ Lawson, DG Lewis, D Clift, ...
Biochemical Society Transactions 33 (4), 796-801, 2005
1662005
The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase
R Neeli, HM Girvan, A Lawrence, MJ Warren, D Leys, NS Scrutton, ...
FEBS letters 579 (25), 5582-5588, 2005
1602005
New developments in ‘ene’-reductase catalysed biological hydrogenations
HS Toogood, NS Scrutton
Current opinion in chemical biology 19, 107-115, 2014
1582014
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