| 2-(Quinolin-4-yloxy)acetamides Are Active against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains K Pissinate, AD Villela, V Rodrigues-Junior, BC Giacobbo, ES Grams, ... ACS medicinal chemistry letters 7 (3), 235-239, 2016 | 54 | 2016 |
| New insights into the SAR and drug combination synergy of 2-(quinolin-4-yloxy) acetamides against Mycobacterium tuberculosis BC Giacobbo, K Pissinate, V Rodrigues-Junior, AD Villela, ES Grams, ... European Journal of Medicinal Chemistry 126, 491-501, 2017 | 50 | 2017 |
| Short-chain fatty acid acetate triggers antiviral response mediated by RIG-I in cells from infants with respiratory syncytial virus bronchiolitis KH Antunes, RT Stein, C Franceschina, EF da Silva, DN de Freitas, ... EBioMedicine 77, 2022 | 49 | 2022 |
| Design, synthesis, and evaluation of new 2-(quinoline-4-yloxy) acetamide-based antituberculosis agents AF Borsoi, JD Paz, BL Abbadi, FS Macchi, N Sperotto, K Pissinate, ... European Journal of Medicinal Chemistry 192, 112179, 2020 | 40 | 2020 |
| 1H-Benzo [d] imidazoles and 3, 4-dihydroquinazolin-4-ones: Design, synthesis and antitubercular activity FS Macchi, K Pissinate, AD Villela, BL Abbadi, V Rodrigues-Junior, ... European Journal of Medicinal Chemistry 155, 153-164, 2018 | 29 | 2018 |
| Handling the hurdles on the way to anti-tuberculosis drug development PF Dalberto, EV De Souza, BL Abbadi, CE Neves, RS Rambo, AS Ramos, ... Frontiers in Chemistry 8, 586294, 2020 | 28 | 2020 |
| Activity of 2-(quinolin-4-yloxy) acetamides in Mycobacterium tuberculosis clinical isolates and identification of their molecular target by whole-genome sequencing FT Subtil, AD Villela, BL Abbadi, VS Rodrigues-Junior, CV Bizarro, ... International Journal of Antimicrobial Agents 51 (3), 378-384, 2018 | 28 | 2018 |
| Mefloquine and its oxazolidine derivative compound are active against drug-resistant Mycobacterium tuberculosis strains and in a murine model of tuberculosis infection VS Rodrigues-Junior, AD Villela, RSB Gonçalves, BL Abbadi, ... International journal of antimicrobial agents 48 (2), 203-207, 2016 | 25 | 2016 |
| Synthesis and mechanistic investigation of iron (II) complexes of isoniazid and derivatives as a redox-mediated activation strategy for anti-tuberculosis therapy J Laborde, C Deraeve, FG de Mesquita Vieira, A Sournia-Saquet, ... Journal of Inorganic Biochemistry 179, 71-81, 2018 | 24 | 2018 |
| Anti-tubercular profile of new selenium-menadione conjugates against Mycobacterium tuberculosis H37Rv (ATCC 27294) strain and multidrug-resistant clinical isolates RCB Ribeiro, DB de Marins, I Di Leo, L da Silva Gomes, MG de Moraes, ... European Journal of Medicinal Chemistry 209, 112859, 2021 | 18 | 2021 |
| Pre-clinical evaluation of quinoxaline-derived chalcones in tuberculosis TC Muradás, BL Abbadi, AD Villela, FS Macchi, PF Bergo, TF de Freitas, ... PLoS One 13 (8), e0202568, 2018 | 18 | 2018 |
| Synthesis and photophysical, thermal and antimycobacterial properties of novel 6-amino-2-alkyl (aryl/heteroaryl)-4-(trifluoromethyl) quinolines YG Kappenberg, A Ketzer, FS Stefanello, PRS Salbego, TV Acunha, ... New Journal of Chemistry 43 (31), 12375-12384, 2019 | 17 | 2019 |
| Is IQG-607 a Potential Metallodrug or Metallopro-Drug With a Defined Molecular Target in Mycobacterium tuberculosis? BL Abbadi, VS Rodrigues-Junior, AS Dadda, K Pissinate, AD Villela, ... Frontiers in Microbiology 9, 880, 2018 | 17 | 2018 |
| Functional, thermodynamics, structural and biological studies of in silico-identified inhibitors of Mycobacterium tuberculosis enoyl-ACP(CoA) reductase enzyme LKB Martinelli, M Rotta, AD Villela, VS Rodrigues-Junior, BL Abbadi, ... Scientific Reports 7 (1), 46696, 2017 | 17 | 2017 |
| Novel 4-aminoquinolines: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase, antitubercular activity, SAR, and preclinical evaluation JD Paz, ND de Moura Sperotto, AS Ramos, K Pissinate, VSR Junior, ... European Journal of Medicinal Chemistry 245, 114908, 2023 | 14 | 2023 |
| Revisiting activation of and mechanism of resistance to compound IQG-607 in Mycobacterium tuberculosis BL Abbadi, AD Villela, VS Rodrigues-Junior, FT Subtil, PF Dalberto, ... Antimicrobial Agents and Chemotherapy 62 (2), 10.1128/aac. 02222-17, 2018 | 14 | 2018 |
| Nonclinical evaluation of IQG-607, an anti-tuberculosis candidate with potential use in combination drug therapy VS Rodrigues-Junior, AD Villela, BL Abbadi, NDM Sperotto, K Pissinate, ... Regulatory Toxicology and Pharmacology 111, 104553, 2020 | 12 | 2020 |
| Antitubercular activity of novel 2-(quinoline-4-yloxy) acetamides with improved drug-like properties AF Borsoi, LM Alice, N Sperotto, AS Ramos, BL Abbadi, FS Macchi Hopf, ... ACS Medicinal Chemistry Letters 13 (8), 1337-1344, 2022 | 10 | 2022 |
| Pentacyanoferrate (II) complex of pyridine-4-and pyrazine-2-hydroxamic acid as source of HNO: investigation of anti-tubercular and vasodilation activities EM Carvalho, T de Freitas Paulo, AS Saquet, BL Abbadi, FS Macchi, ... JBIC Journal of Biological Inorganic Chemistry 25, 887-901, 2020 | 10 | 2020 |
| Effects of tafenoquine against active, dormant and resistant Mycobacterium tuberculosis MGS Sidrônio, APOTC Branco, BL Abbadi, F Macchi, MD Silveira, ... Tuberculosis 128, 102089, 2021 | 7 | 2021 |
Pablo MachadoProfessor da Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande在 pucrs.br 的电子邮件经过验证
