| DNA targeting specificity of RNA-guided Cas9 nucleases PD Hsu, DA Scott, JA Weinstein, FA Ran, S Konermann, V Agarwala, Y Li, ... Nature biotechnology 31 (9), 827-832, 2013 | 5479 | 2013 |
| Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity FA Ran, PD Hsu, CY Lin, JS Gootenberg, S Konermann, AE Trevino, ... Cell 154 (6), 1380-1389, 2013 | 4248 | 2013 |
| Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex S Konermann, MD Brigham, AE Trevino, J Joung, OO Abudayyeh, ... Nature 517 (7536), 583-588, 2015 | 2976 | 2015 |
| Crystal structure of Cas9 in complex with guide RNA and target DNA H Nishimasu, FA Ran, PD Hsu, S Konermann, SI Shehata, N Dohmae, ... Cell 156 (5), 935-949, 2014 | 2385 | 2014 |
| C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector OO Abudayyeh, JS Gootenberg, S Konermann, J Joung, IM Slaymaker, ... Science 353 (6299), aaf5573, 2016 | 2198 | 2016 |
| Discovery and functional characterization of diverse class 2 CRISPR-Cas systems S Shmakov, OO Abudayyeh, KS Makarova, YI Wolf, JS Gootenberg, ... Molecular cell 60 (3), 385-397, 2015 | 1389 | 2015 |
| Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells X Wu, DA Scott, AJ Kriz, AC Chiu, PD Hsu, DB Dadon, AW Cheng, ... Nature biotechnology 32 (7), 670-676, 2014 | 1171 | 2014 |
| Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening J Joung, S Konermann, JS Gootenberg, OO Abudayyeh, RJ Platt, ... Nature protocols 12 (4), 828-863, 2017 | 1151 | 2017 |
| Optical control of mammalian endogenous transcription and epigenetic states S Konermann, MD Brigham, AE Trevino, PD Hsu, M Heidenreich, L Cong, ... Nature 500 (7463), 472-476, 2013 | 1069 | 2013 |
| Transcriptome engineering with RNA-targeting type VI-D CRISPR effectors S Konermann, P Lotfy, NJ Brideau, J Oki, MN Shokhirev, PD Hsu Cell 173 (3), 665-676. e14, 2018 | 1017 | 2018 |
| Genome-Wide Association Study in Asian Populations Identifies Variants in ETS1 and WDFY4 Associated with Systemic Lupus Erythematosus W Yang, N Shen, DQ Ye, Q Liu, Y Zhang, XX Qian, N Hirankarn, D Ying, ... PLoS genetics 6 (2), e1000841, 2010 | 459 | 2010 |
| Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood J Joung, JM Engreitz, S Konermann, OO Abudayyeh, VK Verdine, F Aguet, ... Nature 548 (7667), 343-346, 2017 | 408 | 2017 |
| Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease JE Dahlman, OO Abudayyeh, J Joung, JS Gootenberg, F Zhang, ... Nature biotechnology 33 (11), 1159-1161, 2015 | 305 | 2015 |
| Structural basis for the RNA-guided ribonuclease activity of CRISPR-Cas13d C Zhang, S Konermann, NJ Brideau, P Lotfy, X Wu, SJ Novick, ... Cell 175 (1), 212-223. e17, 2018 | 238 | 2018 |
| Recombinant virus and preparations thereof F Zhang, MD Brigham, L Cong, S Konermann US Patent 11,332,719, 2022 | 228 | 2022 |
| Inducible dna binding proteins and genome perturbation tools and applications thereof F Zhang, M Brigham, L Cong, S Konermann, NE Sanjana | 175 | 2019 |
| Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection SB Biering, SA Sarnik, E Wang, JR Zengel, SR Leist, A Schäfer, ... Nature genetics 54 (8), 1078-1089, 2022 | 74 | 2022 |
| CRISPR enzymes and systems K Severinov, F Zhang, YI Wolf, S Shmakov, E Semenova, L Minakhin, ... US Patent 11,060,115, 2021 | 58 | 2021 |
| C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector. Science 353: aaf5573 OO Abudayyeh, JS Gootenberg, S Konermann, J Joung, IM Slaymaker, ... | 51 | 2016 |
| .(2013) DNA targeting specificity of RNA-guided Cas9 nucleases PD Hsu, DA Scott, JA Weinstein, FA Ran, S Konermann, V Agarwala, Y Li, ... Nat. Biotechnol 31, 827-832, 0 | 51 | |
Patrick D. HsuArc Institute, University of California, Berkeley在 berkeley.edu 的电子邮件经过验证
