| Recon 2.2: from reconstruction to model of human metabolism N Swainston, K Smallbone, H Hefzi, PD Dobson, J Brewer, M Hanscho, ... Metabolomics 12, 1-7, 2016 | 322 | 2016 |
| Sensory maps in the olfactory cortex defined by long-range viral tracing of single neurons S Ghosh, SD Larson, H Hefzi, Z Marnoy, T Cutforth, K Dokka, KK Baldwin Nature 472 (7342), 217-220, 2011 | 305 | 2011 |
| A consensus genome-scale reconstruction of Chinese hamster ovary cell metabolism H Hefzi, KS Ang, M Hanscho, A Bordbar, D Ruckerbauer, M Lakshmanan, ... Cell systems 3 (5), 434-443. e8, 2016 | 249 | 2016 |
| Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion JM Gutierrez, A Feizi, S Li, TB Kallehauge, H Hefzi, LM Grav, D Ley, ... Nature communications 11 (1), 68, 2020 | 111 | 2020 |
| Quantitative feature extraction from the Chinese hamster ovary bioprocess bibliome using a novel meta-analysis workflow A Golabgir, JM Gutierrez, H Hefzi, S Li, BO Palsson, C Herwig, NE Lewis Biotechnology advances 34 (5), 621-633, 2016 | 52 | 2016 |
| Systematic evaluation of site-specific recombinant gene expression for programmable mammalian cell engineering N Pristovsek, S Nallapareddy, LM Grav, H Hefzi, NE Lewis, P Rugbjerg, ... ACS synthetic biology 8 (4), 758-774, 2019 | 50 | 2019 |
| Characterizing posttranslational modifications in prokaryotic metabolism using a multiscale workflow E Brunk, RL Chang, J Xia, H Hefzi, JT Yurkovich, D Kim, E Buckmiller, ... Proceedings of the National Academy of Sciences 115 (43), 11096-11101, 2018 | 47 | 2018 |
| Functional interrogation of Plasmodium genus metabolism identifies species-and stage-specific differences in nutrient essentiality and drug targeting AM Abdel-Haleem, H Hefzi, K Mineta, X Gao, T Gojobori, BO Palsson, ... PLoS computational biology 14 (1), e1005895, 2018 | 39 | 2018 |
| Awakening dormant glycosyltransferases in CHO cells with CRISPRa KJC Karottki, H Hefzi, K Xiong, I Shamie, AH Hansen, S Li, LE Pedersen, ... Biotechnology and bioengineering 117 (2), 593-598, 2020 | 37 | 2020 |
| Reprogramming AA catabolism in CHO cells with CRISPR/Cas9 genome editing improves cell growth and reduces byproduct secretion D Ley, S Pereira, LE Pedersen, J Arnsdorf, H Hefzi, AM Davy, TK Ha, ... Metabolic Engineering 56, 120-129, 2019 | 33 | 2019 |
| An optimized genome-wide, virus-free CRISPR screen for mammalian cells K Xiong, KJ la Cour Karottki, H Hefzi, S Li, LM Grav, S Li, P Spahn, JS Lee, ... Cell Reports Methods 1 (4), 2021 | 27 | 2021 |
| A metabolic CRISPR-Cas9 screen in Chinese hamster ovary cells identifies glutamine-sensitive genes KJ la Cour Karottki, H Hefzi, S Li, LE Pedersen, PN Spahn, C Joshi, ... Metabolic engineering 66, 114-122, 2021 | 21 | 2021 |
| Restoration of DNA repair mitigates genome instability and increases productivity of Chinese hamster ovary cells PN Spahn, X Zhang, Q Hu, H Lu, NK Hamaker, H Hefzi, S Li, CC Kuo, ... Biotechnology and bioengineering 119 (3), 963-982, 2022 | 18 | 2022 |
| WormJam: A consensus C. elegans Metabolic Reconstruction and Metabolomics Community and Workshop Series J Hastings, A Mains, M Artal-Sanz, S Bergmann, BP Braeckman, J Bundy, ... Worm 6 (2), e1373939, 2017 | 17 | 2017 |
| From random mutagenesis to systems biology in metabolic engineering of mammalian cells H Hefzi, NE Lewis Pharmaceutical Bioprocessing 2 (5), 355-358, 2014 | 14 | 2014 |
| A Chinese hamster transcription start site atlas that enables targeted editing of CHO cells I Shamie, SH Duttke, KJC Karottki, CZ Han, AH Hansen, H Hefzi, K Xiong, ... NAR genomics and bioinformatics 3 (3), lqab061, 2021 | 13 | 2021 |
| Enhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium TK Ha, A Òdena, KJC Karottki, CL Kim, H Hefzi, GM Lee, ... Biotechnology and Bioengineering 120 (4), 1159-1166, 2023 | 6 | 2023 |
| Reconstruction of genome-scale metabolic networks H Hefzi, BO Palsson, NE Lewis Handbook of Systems Biology, 229-250, 2013 | 5 | 2013 |
| Systemic post-translational control of bacterial metabolism regulates adaptation in dynamic environments E Brunk, RL Chang, J Xia, H Hefzi, JT Yurkovich, D Kim, E Buckmiller, ... Biorxiv, 180646, 2017 | 3 | 2017 |
| Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening SH Kim, S Shin, M Baek, K Xiong, KJ la Cour Karottki, H Hefzi, LM Grav, ... Metabolic Engineering 80, 66-77, 2023 | 2 | 2023 |
